6Y2I
Crystal structure of M. tuberculosis KasA in complex with N-(1H-indazol-5-yl)butane-1-sulfonamide
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| AAA | 0005515 | molecular_function | protein binding |
| AAA | 0005737 | cellular_component | cytoplasm |
| AAA | 0005829 | cellular_component | cytosol |
| AAA | 0005886 | cellular_component | plasma membrane |
| AAA | 0006629 | biological_process | lipid metabolic process |
| AAA | 0006631 | biological_process | fatty acid metabolic process |
| AAA | 0006633 | biological_process | fatty acid biosynthetic process |
| AAA | 0009274 | cellular_component | peptidoglycan-based cell wall |
| AAA | 0016740 | molecular_function | transferase activity |
| AAA | 0016746 | molecular_function | acyltransferase activity |
| AAA | 0019367 | biological_process | fatty acid elongation, saturated fatty acid |
| AAA | 0030497 | biological_process | fatty acid elongation |
| AAA | 0042802 | molecular_function | identical protein binding |
| BBB | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| BBB | 0005515 | molecular_function | protein binding |
| BBB | 0005737 | cellular_component | cytoplasm |
| BBB | 0005829 | cellular_component | cytosol |
| BBB | 0005886 | cellular_component | plasma membrane |
| BBB | 0006629 | biological_process | lipid metabolic process |
| BBB | 0006631 | biological_process | fatty acid metabolic process |
| BBB | 0006633 | biological_process | fatty acid biosynthetic process |
| BBB | 0009274 | cellular_component | peptidoglycan-based cell wall |
| BBB | 0016740 | molecular_function | transferase activity |
| BBB | 0016746 | molecular_function | acyltransferase activity |
| BBB | 0019367 | biological_process | fatty acid elongation, saturated fatty acid |
| BBB | 0030497 | biological_process | fatty acid elongation |
| BBB | 0042802 | molecular_function | identical protein binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 808 |
| Details | Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24479625","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interacts with the inhibitor thiolactomycin","evidences":[{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
