6Y2I

Crystal structure of M. tuberculosis KasA in complex with N-(1H-indazol-5-yl)butane-1-sulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0006633	biological_process	fatty acid biosynthetic process
AAA	0009274	cellular_component	peptidoglycan-based cell wall
AAA	0016746	molecular_function	acyltransferase activity
AAA	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
AAA	0019367	biological_process	fatty acid elongation, saturated fatty acid
AAA	0030497	biological_process	fatty acid elongation
AAA	0042802	molecular_function	identical protein binding
BBB	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0005886	cellular_component	plasma membrane
BBB	0006633	biological_process	fatty acid biosynthetic process
BBB	0009274	cellular_component	peptidoglycan-based cell wall
BBB	0016746	molecular_function	acyltransferase activity
BBB	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
BBB	0019367	biological_process	fatty acid elongation, saturated fatty acid
BBB	0030497	biological_process	fatty acid elongation
BBB	0042802	molecular_function	identical protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255\|PROSITE-ProRule:PRU01348, ECO:0000305\|PubMed:19604480, ECO:0000305\|PubMed:24108128, ECO:0000305\|PubMed:24479625

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255\|PROSITE-ProRule:PRU01348

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:19604480, ECO:0000305\|PubMed:24108128

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Interacts with the inhibitor thiolactomycin => ECO:0000269\|PubMed:19604480, ECO:0000269\|PubMed:24108128