6Y1E

Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000302	biological_process	response to reactive oxygen species
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0007417	biological_process	central nervous system development
A	0008432	molecular_function	JUN kinase binding
A	0009636	biological_process	response to toxic substance
A	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
A	0014003	biological_process	oligodendrocyte development
A	0015643	molecular_function	toxic substance binding
A	0016740	molecular_function	transferase activity
A	0019901	molecular_function	protein kinase binding
A	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
A	0031100	biological_process	animal organ regeneration
A	0031667	biological_process	response to nutrient levels
A	0031982	cellular_component	vesicle
A	0032355	biological_process	response to estradiol
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0032720	biological_process	negative regulation of tumor necrosis factor production
A	0032869	biological_process	cellular response to insulin stimulus
A	0032872	biological_process	regulation of stress-activated MAPK cascade
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0033591	biological_process	response to L-ascorbic acid
A	0034774	cellular_component	secretory granule lumen
A	0035726	biological_process	common myeloid progenitor cell proliferation
A	0035730	molecular_function	S-nitrosoglutathione binding
A	0035731	molecular_function	dinitrosyl-iron complex binding
A	0035732	biological_process	nitric oxide storage
A	0043066	biological_process	negative regulation of apoptotic process
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043200	biological_process	response to amino acid
A	0043409	biological_process	negative regulation of MAPK cascade
A	0043651	biological_process	linoleic acid metabolic process
A	0045471	biological_process	response to ethanol
A	0046329	biological_process	negative regulation of JNK cascade
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0051122	biological_process	hepoxilin biosynthetic process
A	0070026	molecular_function	nitric oxide binding
A	0070062	cellular_component	extracellular exosome
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0070664	biological_process	negative regulation of leukocyte proliferation
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0071385	biological_process	cellular response to glucocorticoid stimulus
A	0071460	biological_process	cellular response to cell-matrix adhesion
A	0071638	biological_process	negative regulation of monocyte chemotactic protein-1 production
A	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
A	0097057	cellular_component	TRAF2-GSTP1 complex
A	0098869	biological_process	cellular oxidant detoxification
A	0110076	biological_process	negative regulation of ferroptosis
A	1901687	biological_process	glutathione derivative biosynthetic process
A	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000302	biological_process	response to reactive oxygen species
B	0002674	biological_process	negative regulation of acute inflammatory response
B	0004364	molecular_function	glutathione transferase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0007417	biological_process	central nervous system development
B	0008432	molecular_function	JUN kinase binding
B	0009636	biological_process	response to toxic substance
B	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
B	0014003	biological_process	oligodendrocyte development
B	0015643	molecular_function	toxic substance binding
B	0016740	molecular_function	transferase activity
B	0019901	molecular_function	protein kinase binding
B	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
B	0031100	biological_process	animal organ regeneration
B	0031667	biological_process	response to nutrient levels
B	0031982	cellular_component	vesicle
B	0032355	biological_process	response to estradiol
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0032720	biological_process	negative regulation of tumor necrosis factor production
B	0032869	biological_process	cellular response to insulin stimulus
B	0032872	biological_process	regulation of stress-activated MAPK cascade
B	0032873	biological_process	negative regulation of stress-activated MAPK cascade
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0033591	biological_process	response to L-ascorbic acid
B	0034774	cellular_component	secretory granule lumen
B	0035726	biological_process	common myeloid progenitor cell proliferation
B	0035730	molecular_function	S-nitrosoglutathione binding
B	0035731	molecular_function	dinitrosyl-iron complex binding
B	0035732	biological_process	nitric oxide storage
B	0043066	biological_process	negative regulation of apoptotic process
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043200	biological_process	response to amino acid
B	0043409	biological_process	negative regulation of MAPK cascade
B	0043651	biological_process	linoleic acid metabolic process
B	0045471	biological_process	response to ethanol
B	0046329	biological_process	negative regulation of JNK cascade
B	0048147	biological_process	negative regulation of fibroblast proliferation
B	0051122	biological_process	hepoxilin biosynthetic process
B	0070026	molecular_function	nitric oxide binding
B	0070062	cellular_component	extracellular exosome
B	0070372	biological_process	regulation of ERK1 and ERK2 cascade
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0070664	biological_process	negative regulation of leukocyte proliferation
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071364	biological_process	cellular response to epidermal growth factor stimulus
B	0071385	biological_process	cellular response to glucocorticoid stimulus
B	0071460	biological_process	cellular response to cell-matrix adhesion
B	0071638	biological_process	negative regulation of monocyte chemotactic protein-1 production
B	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
B	0097057	cellular_component	TRAF2-GSTP1 complex
B	0098869	biological_process	cellular oxidant detoxification
B	0110076	biological_process	negative regulation of ferroptosis
B	1901687	biological_process	glutathione derivative biosynthetic process
B	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000302	biological_process	response to reactive oxygen species
C	0002674	biological_process	negative regulation of acute inflammatory response
C	0004364	molecular_function	glutathione transferase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0007417	biological_process	central nervous system development
C	0008432	molecular_function	JUN kinase binding
C	0009636	biological_process	response to toxic substance
C	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
C	0014003	biological_process	oligodendrocyte development
C	0015643	molecular_function	toxic substance binding
C	0016740	molecular_function	transferase activity
C	0019901	molecular_function	protein kinase binding
C	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
C	0031100	biological_process	animal organ regeneration
C	0031667	biological_process	response to nutrient levels
C	0031982	cellular_component	vesicle
C	0032355	biological_process	response to estradiol
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0032720	biological_process	negative regulation of tumor necrosis factor production
C	0032869	biological_process	cellular response to insulin stimulus
C	0032872	biological_process	regulation of stress-activated MAPK cascade
C	0032873	biological_process	negative regulation of stress-activated MAPK cascade
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0033591	biological_process	response to L-ascorbic acid
C	0034774	cellular_component	secretory granule lumen
C	0035726	biological_process	common myeloid progenitor cell proliferation
C	0035730	molecular_function	S-nitrosoglutathione binding
C	0035731	molecular_function	dinitrosyl-iron complex binding
C	0035732	biological_process	nitric oxide storage
C	0043066	biological_process	negative regulation of apoptotic process
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043200	biological_process	response to amino acid
C	0043409	biological_process	negative regulation of MAPK cascade
C	0043651	biological_process	linoleic acid metabolic process
C	0045471	biological_process	response to ethanol
C	0046329	biological_process	negative regulation of JNK cascade
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0051122	biological_process	hepoxilin biosynthetic process
C	0070026	molecular_function	nitric oxide binding
C	0070062	cellular_component	extracellular exosome
C	0070372	biological_process	regulation of ERK1 and ERK2 cascade
C	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
C	0070664	biological_process	negative regulation of leukocyte proliferation
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071364	biological_process	cellular response to epidermal growth factor stimulus
C	0071385	biological_process	cellular response to glucocorticoid stimulus
C	0071460	biological_process	cellular response to cell-matrix adhesion
C	0071638	biological_process	negative regulation of monocyte chemotactic protein-1 production
C	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
C	0097057	cellular_component	TRAF2-GSTP1 complex
C	0098869	biological_process	cellular oxidant detoxification
C	0110076	biological_process	negative regulation of ferroptosis
C	1901687	biological_process	glutathione derivative biosynthetic process
C	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000302	biological_process	response to reactive oxygen species
D	0002674	biological_process	negative regulation of acute inflammatory response
D	0004364	molecular_function	glutathione transferase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0007417	biological_process	central nervous system development
D	0008432	molecular_function	JUN kinase binding
D	0009636	biological_process	response to toxic substance
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0014003	biological_process	oligodendrocyte development
D	0015643	molecular_function	toxic substance binding
D	0016740	molecular_function	transferase activity
D	0019901	molecular_function	protein kinase binding
D	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
D	0031100	biological_process	animal organ regeneration
D	0031667	biological_process	response to nutrient levels
D	0031982	cellular_component	vesicle
D	0032355	biological_process	response to estradiol
D	0032691	biological_process	negative regulation of interleukin-1 beta production
D	0032720	biological_process	negative regulation of tumor necrosis factor production
D	0032869	biological_process	cellular response to insulin stimulus
D	0032872	biological_process	regulation of stress-activated MAPK cascade
D	0032873	biological_process	negative regulation of stress-activated MAPK cascade
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0033591	biological_process	response to L-ascorbic acid
D	0034774	cellular_component	secretory granule lumen
D	0035726	biological_process	common myeloid progenitor cell proliferation
D	0035730	molecular_function	S-nitrosoglutathione binding
D	0035731	molecular_function	dinitrosyl-iron complex binding
D	0035732	biological_process	nitric oxide storage
D	0043066	biological_process	negative regulation of apoptotic process
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043200	biological_process	response to amino acid
D	0043409	biological_process	negative regulation of MAPK cascade
D	0043651	biological_process	linoleic acid metabolic process
D	0045471	biological_process	response to ethanol
D	0046329	biological_process	negative regulation of JNK cascade
D	0048147	biological_process	negative regulation of fibroblast proliferation
D	0051122	biological_process	hepoxilin biosynthetic process
D	0070026	molecular_function	nitric oxide binding
D	0070062	cellular_component	extracellular exosome
D	0070372	biological_process	regulation of ERK1 and ERK2 cascade
D	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
D	0070664	biological_process	negative regulation of leukocyte proliferation
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0071364	biological_process	cellular response to epidermal growth factor stimulus
D	0071385	biological_process	cellular response to glucocorticoid stimulus
D	0071460	biological_process	cellular response to cell-matrix adhesion
D	0071638	biological_process	negative regulation of monocyte chemotactic protein-1 production
D	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
D	0097057	cellular_component	TRAF2-GSTP1 complex
D	0098869	biological_process	cellular oxidant detoxification
D	0110076	biological_process	negative regulation of ferroptosis
D	1901687	biological_process	glutathione derivative biosynthetic process
D	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue GSH A 301

Chain	Residue
A	TYR7
A	SER65
A	HOH433
A	HOH447
A	HOH469
A	HOH475
A	HOH500
A	HOH580
B	ASP98
A	PHE8
A	ARG13
A	TRP38
A	LYS44
A	GLN51
A	LEU52
A	PRO53
A	GLN64

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MES A 302

Chain	Residue
A	ALA22
A	TRP28
A	GLU197
A	HOH413
A	HOH439
C	ASP171
C	ALA172

---

site_id	AC3
Number of Residues	12
Details	binding site for residue O7Z A 303

Chain	Residue
A	PHE142
A	GLN147
A	ILE148
A	ARG186
A	HOH408
A	HOH410
A	HOH489
D	ASP23
D	GLN24
D	ARG186
D	LYS188
D	HOH447

---

site_id	AC4
Number of Residues	18
Details	binding site for residue GSH B 301

Chain	Residue
A	ASP98
B	TYR7
B	PHE8
B	ARG13
B	TRP38
B	LYS44
B	GLN51
B	LEU52
B	PRO53
B	GLN64
B	SER65
B	HOH433
B	HOH444
B	HOH457
B	HOH465
B	HOH505
B	HOH532
B	HOH584

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MES B 302

Chain	Residue
B	ALA22
B	TRP28
B	GLU197
B	O7Z304
B	HOH434
B	HOH472

---

site_id	AC6
Number of Residues	8
Details	binding site for residue MES B 303

Chain	Residue
A	ARG74
B	ARG74
B	TYR79
B	GLY80
B	ASP82
B	HOH401
B	HOH483
B	HOH567

---

site_id	AC7
Number of Residues	6
Details	binding site for residue O7Z B 304

Chain	Residue
B	SER27
B	TRP28
B	MES302
B	HOH404
B	HOH494
B	HOH516

---

site_id	AC8
Number of Residues	15
Details	binding site for residue GSH C 301

Chain	Residue
C	TYR7
C	PHE8
C	ARG13
C	TRP38
C	LYS44
C	GLN51
C	LEU52
C	PRO53
C	GLN64
C	SER65
C	HOH468
C	HOH469
C	HOH472
C	HOH557
C	HOH566

---

site_id	AC9
Number of Residues	6
Details	binding site for residue MES C 302

Chain	Residue
A	HOH414
C	ALA22
C	TRP28
C	GLU197
C	HOH464
C	HOH478

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PGE C 303

Chain	Residue
C	THR61
C	HOH403
C	VAL6
C	GLU31
C	LYS54
C	GLN56

---

site_id	AD2
Number of Residues	17
Details	binding site for residue GSH D 301

Chain	Residue
D	TYR7
D	PHE8
D	ARG13
D	TRP38
D	LYS44
D	GLN51
D	LEU52
D	PRO53
D	GLN64
D	SER65
D	HOH451
D	HOH481
D	HOH483
D	HOH499
D	HOH562
D	HOH577
D	HOH581

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MES D 302

Chain	Residue
D	ALA22
D	TRP28
D	PHE192
D	GLU197
D	HOH465

---

site_id	AD4
Number of Residues	10
Details	binding site for residue MES D 303

Chain	Residue
C	GLU36
D	ARG74
D	TYR79
D	GLY80
D	LYS81
D	ASP82
D	ALA86
D	O7Z305
D	HOH403
D	HOH411

---

site_id	AD5
Number of Residues	5
Details	binding site for residue PGE D 304

Chain	Residue
D	GLU31
D	LEU43
D	LYS54
D	GLN56
D	THR61

---

site_id	AD6
Number of Residues	1
Details	binding site for residue O7Z D 305

Chain	Residue
D	MES303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	237
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	484
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1522586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19396894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19808963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9012673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9245401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9351803","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9398518","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"19254954","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P19157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---