6Y1A

Amyloid fibril structure of islet amyloid polypeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
M	0005179	molecular_function	hormone activity
M	0005576	cellular_component	extracellular region
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
O	0005179	molecular_function	hormone activity
O	0005576	cellular_component	extracellular region
P	0005179	molecular_function	hormone activity
P	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NH2 A 101

Chain	Residue
A	TYR37
B	ASN21
C	TYR37

---

site_id	AC2
Number of Residues	5
Details	binding site for Di-peptide NH2 B 101 and TYR B 37

Chain	Residue
B	ASN31
B	ASN35
B	THR36
C	PHE23
D	TYR37

---

site_id	AC3
Number of Residues	11
Details	binding site for Di-peptide NH2 C 101 and TYR C 37

Chain	Residue
A	TYR37
A	NH2101
B	ASN21
C	ASN31
C	ASN35
C	THR36
D	ASN21
D	PHE23
E	LEU27
E	TYR37
A	THR36

---

site_id	AC4
Number of Residues	10
Details	binding site for Di-peptide NH2 D 101 and TYR D 37

Chain	Residue
B	THR36
B	TYR37
B	NH2101
D	ASN31
D	ASN35
D	THR36
E	ASN21
E	PHE23
F	LEU27
F	TYR37

---

site_id	AC5
Number of Residues	9
Details	binding site for Di-peptide NH2 E 101 and TYR E 37

Chain	Residue
C	THR36
C	TYR37
C	NH2101
E	ASN31
E	ASN35
E	THR36
F	ASN21
F	PHE23
G	TYR37

---

site_id	AC6
Number of Residues	9
Details	binding site for Di-peptide NH2 F 101 and TYR F 37

Chain	Residue
D	THR36
D	TYR37
D	NH2101
F	ASN31
F	ASN35
F	THR36
G	ASN21
G	PHE23
H	TYR37

---

site_id	AC7
Number of Residues	9
Details	binding site for Di-peptide NH2 G 101 and TYR G 37

Chain	Residue
E	THR36
E	TYR37
E	NH2101
G	ASN31
G	ASN35
G	THR36
H	ASN21
H	PHE23
I	TYR37

---

site_id	AC8
Number of Residues	10
Details	binding site for Di-peptide NH2 H 101 and TYR H 37

Chain	Residue
F	THR36
F	TYR37
F	NH2101
H	ASN31
H	ASN35
H	THR36
I	ASN21
I	PHE23
J	LEU27
J	TYR37

---

site_id	AC9
Number of Residues	8
Details	binding site for Di-peptide NH2 I 101 and TYR I 37

Chain	Residue
G	THR36
G	TYR37
G	NH2101
I	ASN31
I	ASN35
I	THR36
J	PHE23
K	TYR37

---

site_id	AD1
Number of Residues	9
Details	binding site for Di-peptide NH2 J 101 and TYR J 37

Chain	Residue
H	THR36
H	TYR37
H	NH2101
J	ASN31
J	ASN35
J	THR36
K	ASN21
K	PHE23
L	TYR37

---

site_id	AD2
Number of Residues	10
Details	binding site for Di-peptide NH2 K 101 and TYR K 37

Chain	Residue
I	THR36
I	TYR37
I	NH2101
K	ASN31
K	ASN35
K	THR36
L	ASN21
L	PHE23
M	LEU27
M	TYR37

---

site_id	AD3
Number of Residues	9
Details	binding site for Di-peptide NH2 L 101 and TYR L 37

Chain	Residue
M	PHE23
N	LEU27
N	TYR37
J	THR36
J	TYR37
J	NH2101
L	ASN31
L	ASN35
L	THR36

---

site_id	AD4
Number of Residues	9
Details	binding site for Di-peptide NH2 M 101 and TYR M 37

Chain	Residue
K	THR36
K	TYR37
K	NH2101
M	ASN31
M	ASN35
M	THR36
N	ASN21
N	PHE23
O	TYR37

---

site_id	AD5
Number of Residues	8
Details	binding site for Di-peptide NH2 N 101 and TYR N 37

Chain	Residue
L	THR36
L	TYR37
L	NH2101
N	ASN31
N	ASN35
N	THR36
O	PHE23
P	TYR37

---

site_id	AD6
Number of Residues	7
Details	binding site for Di-peptide NH2 O 101 and TYR O 37

Chain	Residue
M	THR36
M	TYR37
M	NH2101
O	ASN31
O	ASN35
O	THR36
P	PHE23

---

site_id	AD7
Number of Residues	6
Details	binding site for Di-peptide NH2 P 101 and TYR P 37

Chain	Residue
N	THR36
N	TYR37
N	NH2101
P	ASN31
P	ASN35
P	THR36

---

Functional Information from PROSITE/UniProt

site_id	PS00258
Number of Residues	15
Details	CALCITONIN Calcitonin / CGRP / IAPP family signature. CNT.ATCAtqrLanfL

Chain	Residue	Details
A	CYS2-LEU16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Modified residue: {"description":"Tyrosine amide","evidences":[{"source":"PubMed","id":"2651160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3053705","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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