6Y0M

Crystal structure of human CD23 lectin domain N225D, K229E, S252N, T251N mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002925	biological_process	positive regulation of humoral immune response mediated by circulating immunoglobulin
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0005887	cellular_component	integral component of plasma membrane
A	0009897	cellular_component	external side of plasma membrane
A	0016020	cellular_component	membrane
A	0016021	cellular_component	integral component of membrane
A	0019863	molecular_function	IgE binding
A	0030246	molecular_function	carbohydrate binding
A	0046872	molecular_function	metal ion binding
A	0051000	biological_process	positive regulation of nitric-oxide synthase activity
A	0051712	biological_process	positive regulation of killing of cells of other organism
A	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
A	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	24
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVmmrgsgr.....WNDAFCdrklgaWVC

Chain	Residue	Details
A	CYS259-CYS282

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16765898

Chain	Residue	Details
A	GLU249
A	ASN251
A	ASN269
A	ASP270

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:37453717

Chain	Residue	Details
A	SER296

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