6XYY

Update of ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE 9-(3-PHENYLMETHYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE

Replaces:  1DX4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001507	biological_process	acetylcholine catabolic process in synaptic cleft
A	0003990	molecular_function	acetylcholinesterase activity
A	0004104	molecular_function	cholinesterase activity
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006581	biological_process	acetylcholine catabolic process
A	0007268	biological_process	chemical synaptic transmission
A	0008233	molecular_function	peptidase activity
A	0017171	molecular_function	serine hydrolase activity
A	0019695	biological_process	choline metabolic process
A	0042426	biological_process	choline catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0043083	cellular_component	synaptic cleft
A	0043199	molecular_function	sulfate binding
A	0045202	cellular_component	synapse
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0098552	cellular_component	side of membrane

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGnpewMtLfGeSAG

Chain	Residue	Details
A	PHE225-GLY240

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site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYINVWaP

Chain	Residue	Details
A	GLU91-PRO101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate

Chain	Residue	Details
A	SER238

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	GLU367
A	HIS480

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Not glycosylated => ECO:0000269|PubMed:1730712

Chain	Residue	Details
A	ASN531

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site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: GPI-anchor amidated serine => ECO:0000255

Chain	Residue	Details
A	SER581

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1730712

Chain	Residue	Details
A	ASN88
A	ASN136
A	ASN293
A	ASN493

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