Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0009098 | biological_process | L-leucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0009098 | biological_process | L-leucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 31 |
Details | binding site for residue NAD A 401 |
Chain | Residue |
A | ILE14 |
A | GLU280 |
A | GLY283 |
A | GLY284 |
A | SER285 |
A | ALA286 |
A | PRO287 |
A | ASP288 |
A | ILE289 |
A | ASN296 |
A | O45404 |
A | SER74 |
A | HOH518 |
A | HOH540 |
A | HOH542 |
A | HOH562 |
A | HOH570 |
A | HOH620 |
A | HOH637 |
B | ASN196 |
B | TYR224 |
B | ASN227 |
A | VAL75 |
B | HOH562 |
B | HOH563 |
A | GLY76 |
A | GLY77 |
A | GLU90 |
A | LEU94 |
A | MET263 |
A | GLY264 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MG A 402 |
Chain | Residue |
A | ARG108 |
A | ASP250 |
A | SER253 |
A | ASP254 |
A | O45404 |
B | ASP226 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MG A 403 |
Chain | Residue |
A | ASP226 |
B | ASP250 |
B | ASP254 |
B | O45402 |
B | HOH509 |
B | HOH511 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue O45 A 404 |
Chain | Residue |
A | GLU90 |
A | ARG98 |
A | ARG108 |
A | ARG137 |
A | ASP250 |
A | ALA282 |
A | NAD401 |
A | MG402 |
A | HOH541 |
B | LYS194 |
B | ASP226 |
site_id | AC5 |
Number of Residues | 31 |
Details | binding site for residue NAD B 401 |
Chain | Residue |
A | ASN196 |
A | TYR224 |
A | ASN227 |
A | HOH593 |
B | ILE14 |
B | SER74 |
B | VAL75 |
B | GLY76 |
B | GLY77 |
B | GLU90 |
B | LEU94 |
B | MET263 |
B | GLY264 |
B | GLU280 |
B | GLY283 |
B | GLY284 |
B | SER285 |
B | ALA286 |
B | PRO287 |
B | ASP288 |
B | ILE289 |
B | ASN296 |
B | ASP337 |
B | O45402 |
B | HOH508 |
B | HOH512 |
B | HOH525 |
B | HOH527 |
B | HOH532 |
B | HOH554 |
B | HOH582 |
site_id | AC6 |
Number of Residues | 15 |
Details | binding site for residue O45 B 402 |
Chain | Residue |
B | HOH511 |
A | LYS194 |
A | ASN196 |
A | ASP226 |
A | MG403 |
B | GLU90 |
B | LEU95 |
B | ARG98 |
B | ARG108 |
B | ARG137 |
B | ASP250 |
B | ALA282 |
B | NAD401 |
B | HOH507 |
B | HOH509 |
Functional Information from PROSITE/UniProt
site_id | PS00470 |
Number of Residues | 20 |
Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIiSDeaAmit.GSMGM |
Chain | Residue | Details |
A | ASN246-MET265 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | GLY77 | |
B | ARG98 | |
B | ARG108 | |
B | ARG137 | |
B | ASP226 | |
B | ASP250 | |
B | ASP254 | |
B | GLY284 | |
A | ARG98 | |
A | ARG108 | |
A | ARG137 | |
A | ASP226 | |
A | ASP250 | |
A | ASP254 | |
A | GLY284 | |
B | GLY77 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Important for catalysis => ECO:0000250 |
Chain | Residue | Details |
A | TYR144 | |
A | LYS194 | |
B | TYR144 | |
B | LYS194 | |