6XXY
Crystal structure of Haemophilus influenzae 3-isopropylmalate dehydrogenase in complex with O-isobutenyl oxalylhydroxamate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | ILE14 |
| A | GLU280 |
| A | GLY283 |
| A | GLY284 |
| A | SER285 |
| A | ALA286 |
| A | PRO287 |
| A | ASP288 |
| A | ILE289 |
| A | ASN296 |
| A | O45404 |
| A | SER74 |
| A | HOH518 |
| A | HOH540 |
| A | HOH542 |
| A | HOH562 |
| A | HOH570 |
| A | HOH620 |
| A | HOH637 |
| B | ASN196 |
| B | TYR224 |
| B | ASN227 |
| A | VAL75 |
| B | HOH562 |
| B | HOH563 |
| A | GLY76 |
| A | GLY77 |
| A | GLU90 |
| A | LEU94 |
| A | MET263 |
| A | GLY264 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ARG108 |
| A | ASP250 |
| A | SER253 |
| A | ASP254 |
| A | O45404 |
| B | ASP226 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP226 |
| B | ASP250 |
| B | ASP254 |
| B | O45402 |
| B | HOH509 |
| B | HOH511 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue O45 A 404 |
| Chain | Residue |
| A | GLU90 |
| A | ARG98 |
| A | ARG108 |
| A | ARG137 |
| A | ASP250 |
| A | ALA282 |
| A | NAD401 |
| A | MG402 |
| A | HOH541 |
| B | LYS194 |
| B | ASP226 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| A | ASN196 |
| A | TYR224 |
| A | ASN227 |
| A | HOH593 |
| B | ILE14 |
| B | SER74 |
| B | VAL75 |
| B | GLY76 |
| B | GLY77 |
| B | GLU90 |
| B | LEU94 |
| B | MET263 |
| B | GLY264 |
| B | GLU280 |
| B | GLY283 |
| B | GLY284 |
| B | SER285 |
| B | ALA286 |
| B | PRO287 |
| B | ASP288 |
| B | ILE289 |
| B | ASN296 |
| B | ASP337 |
| B | O45402 |
| B | HOH508 |
| B | HOH512 |
| B | HOH525 |
| B | HOH527 |
| B | HOH532 |
| B | HOH554 |
| B | HOH582 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue O45 B 402 |
| Chain | Residue |
| B | HOH511 |
| A | LYS194 |
| A | ASN196 |
| A | ASP226 |
| A | MG403 |
| B | GLU90 |
| B | LEU95 |
| B | ARG98 |
| B | ARG108 |
| B | ARG137 |
| B | ASP250 |
| B | ALA282 |
| B | NAD401 |
| B | HOH507 |
| B | HOH509 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIiSDeaAmit.GSMGM |
| Chain | Residue | Details |
| A | ASN246-MET265 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 62 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
