6XU4
Crystal structure of the genetically-encoded FGCaMP calcium indicator in its calcium-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001411 | cellular_component | hyphal tip |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005823 | cellular_component | central plaque of spindle pole body |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| A | 0009847 | biological_process | spore germination |
| A | 0030234 | molecular_function | enzyme regulator activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051286 | cellular_component | cell tip |
| A | 0051300 | biological_process | spindle pole body organization |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0001411 | cellular_component | hyphal tip |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005823 | cellular_component | central plaque of spindle pole body |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0008218 | biological_process | bioluminescence |
| B | 0009847 | biological_process | spore germination |
| B | 0030234 | molecular_function | enzyme regulator activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051286 | cellular_component | cell tip |
| B | 0051300 | biological_process | spindle pole body organization |
| B | 0051726 | biological_process | regulation of cell cycle |
| E | 0001411 | cellular_component | hyphal tip |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0005823 | cellular_component | central plaque of spindle pole body |
| E | 0006091 | biological_process | generation of precursor metabolites and energy |
| E | 0008218 | biological_process | bioluminescence |
| E | 0009847 | biological_process | spore germination |
| E | 0030234 | molecular_function | enzyme regulator activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0051286 | cellular_component | cell tip |
| E | 0051300 | biological_process | spindle pole body organization |
| E | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 501 |
| Chain | Residue |
| A | ASP323 |
| A | ASP325 |
| A | ASN327 |
| A | THR329 |
| A | ASP331 |
| A | GLU334 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | PHE366 |
| A | GLU371 |
| A | ASP360 |
| A | ASP362 |
| A | ASN364 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 503 |
| Chain | Residue |
| A | ASP287 |
| A | ASP289 |
| A | ASP291 |
| A | GLN293 |
| A | GLU298 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 504 |
| Chain | Residue |
| A | ASP396 |
| A | ASP398 |
| A | ASP400 |
| A | ARG402 |
| A | GLU407 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 501 |
| Chain | Residue |
| B | ASP287 |
| B | ASP289 |
| B | ASP291 |
| B | GLN293 |
| B | GLU298 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 502 |
| Chain | Residue |
| B | ASP323 |
| B | ASP325 |
| B | ASN327 |
| B | THR329 |
| B | ASP331 |
| B | GLU334 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 503 |
| Chain | Residue |
| B | ASP360 |
| B | ASP362 |
| B | ASN364 |
| B | PHE366 |
| B | GLU371 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 504 |
| Chain | Residue |
| B | ASP396 |
| B | ASP398 |
| B | ASP400 |
| B | ARG402 |
| B | GLU407 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue CA E 501 |
| Chain | Residue |
| E | ASP287 |
| E | ASP289 |
| E | ASP291 |
| E | GLN293 |
| E | GLU298 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA E 502 |
| Chain | Residue |
| E | ASP323 |
| E | ASP325 |
| E | ASN327 |
| E | THR329 |
| E | ASP331 |
| E | GLU334 |
| site_id | AD2 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide LEU B 183 and CRO B 185 |
| Chain | Residue |
| B | ASN23 |
| B | ILE41 |
| B | VAL77 |
| B | LEU94 |
| B | GLU96 |
| B | LEU163 |
| B | PHE165 |
| B | LEU179 |
| B | VAL180 |
| B | THR181 |
| B | THR182 |
| B | VAL187 |
| B | GLN188 |
| B | GLN213 |
| B | ARG215 |
| B | ASN240 |
| site_id | AD3 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide CRO B 185 and VAL B 187 |
| Chain | Residue |
| B | ASN23 |
| B | ILE41 |
| B | VAL77 |
| B | LEU94 |
| B | GLU96 |
| B | LEU161 |
| B | LEU163 |
| B | VAL180 |
| B | THR181 |
| B | THR182 |
| B | LEU183 |
| B | GLN188 |
| B | CYS189 |
| B | PHE190 |
| B | GLN213 |
| B | ARG215 |
| B | LEU238 |
| B | ASN240 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGQITtkEL |
| Chain | Residue | Details |
| A | ASP289-THR301 | |
| A | ASP325-THR337 | |
| A | ASP362-HIS374 | |
| A | ASP398-GLN410 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 57 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | ASP287 | |
| A | GLU334 | |
| A | ASP360 | |
| A | ASP362 | |
| A | ASN364 | |
| A | GLU371 | |
| A | ASP396 | |
| A | ASP398 | |
| A | ASP400 | |
| A | ARG402 | |
| A | GLU407 | |
| A | ASP289 | |
| B | ASP287 | |
| B | ASP289 | |
| B | ASP291 | |
| B | GLN293 | |
| B | GLU298 | |
| B | ASP323 | |
| B | ASP325 | |
| B | ASN327 | |
| B | THR329 | |
| B | GLU334 | |
| A | ASP291 | |
| B | ASP360 | |
| B | ASP362 | |
| B | ASN364 | |
| B | GLU371 | |
| B | ASP396 | |
| B | ASP398 | |
| B | ASP400 | |
| B | ARG402 | |
| B | GLU407 | |
| E | ASP287 | |
| A | GLN293 | |
| E | ASP289 | |
| E | ASP291 | |
| E | GLN293 | |
| E | GLU298 | |
| E | ASP323 | |
| E | ASP325 | |
| E | ASN327 | |
| E | THR329 | |
| E | GLU334 | |
| E | ASP360 | |
| A | GLU298 | |
| E | ASP362 | |
| E | ASN364 | |
| E | GLU371 | |
| E | ASP396 | |
| E | ASP398 | |
| E | ASP400 | |
| E | ARG402 | |
| E | GLU407 | |
| A | ASP323 | |
| A | ASP325 | |
| A | ASN327 | |
| A | THR329 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA268 | |
| B | ALA268 | |
| E | ALA268 |
