6XU4

Crystal structure of the genetically-encoded FGCaMP calcium indicator in its calcium-bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0001411	cellular_component	hyphal tip
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0005823	cellular_component	central plaque of spindle pole body
A	0006091	biological_process	generation of precursor metabolites and energy
A	0008218	biological_process	bioluminescence
A	0009847	biological_process	spore germination
A	0030234	molecular_function	enzyme regulator activity
A	0051286	cellular_component	cell tip
A	0051300	biological_process	spindle pole body organization
A	0051726	biological_process	regulation of cell cycle
B	0000226	biological_process	microtubule cytoskeleton organization
B	0001411	cellular_component	hyphal tip
B	0005509	molecular_function	calcium ion binding
B	0005737	cellular_component	cytoplasm
B	0005823	cellular_component	central plaque of spindle pole body
B	0006091	biological_process	generation of precursor metabolites and energy
B	0008218	biological_process	bioluminescence
B	0009847	biological_process	spore germination
B	0030234	molecular_function	enzyme regulator activity
B	0051286	cellular_component	cell tip
B	0051300	biological_process	spindle pole body organization
B	0051726	biological_process	regulation of cell cycle
E	0000226	biological_process	microtubule cytoskeleton organization
E	0001411	cellular_component	hyphal tip
E	0005509	molecular_function	calcium ion binding
E	0005737	cellular_component	cytoplasm
E	0005823	cellular_component	central plaque of spindle pole body
E	0006091	biological_process	generation of precursor metabolites and energy
E	0008218	biological_process	bioluminescence
E	0009847	biological_process	spore germination
E	0030234	molecular_function	enzyme regulator activity
E	0051286	cellular_component	cell tip
E	0051300	biological_process	spindle pole body organization
E	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 501

Chain	Residue
A	ASP323
A	ASP325
A	ASN327
A	THR329
A	ASP331
A	GLU334

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 502

Chain	Residue
A	PHE366
A	GLU371
A	ASP360
A	ASP362
A	ASN364

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 503

Chain	Residue
A	ASP287
A	ASP289
A	ASP291
A	GLN293
A	GLU298

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA A 504

Chain	Residue
A	ASP396
A	ASP398
A	ASP400
A	ARG402
A	GLU407

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA B 501

Chain	Residue
B	ASP287
B	ASP289
B	ASP291
B	GLN293
B	GLU298

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA B 502

Chain	Residue
B	ASP323
B	ASP325
B	ASN327
B	THR329
B	ASP331
B	GLU334

---

site_id	AC7
Number of Residues	5
Details	binding site for residue CA B 503

Chain	Residue
B	ASP360
B	ASP362
B	ASN364
B	PHE366
B	GLU371

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CA B 504

Chain	Residue
B	ASP396
B	ASP398
B	ASP400
B	ARG402
B	GLU407

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA E 501

Chain	Residue
E	ASP287
E	ASP289
E	ASP291
E	GLN293
E	GLU298

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA E 502

Chain	Residue
E	ASP323
E	ASP325
E	ASN327
E	THR329
E	ASP331
E	GLU334

---

site_id	AD2
Number of Residues	16
Details	binding site for Di-peptide LEU B 183 and CRO B 185

Chain	Residue
B	ASN23
B	ILE41
B	VAL77
B	LEU94
B	GLU96
B	LEU163
B	PHE165
B	LEU179
B	VAL180
B	THR181
B	THR182
B	VAL187
B	GLN188
B	GLN213
B	ARG215
B	ASN240

---

site_id	AD3
Number of Residues	18
Details	binding site for Di-peptide CRO B 185 and VAL B 187

Chain	Residue
B	ASN23
B	ILE41
B	VAL77
B	LEU94
B	GLU96
B	LEU161
B	LEU163
B	VAL180
B	THR181
B	THR182
B	LEU183
B	GLN188
B	CYS189
B	PHE190
B	GLN213
B	ARG215
B	LEU238
B	ASN240

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGQITtkEL

Chain	Residue	Details
A	ASP289-THR301
A	ASP325-THR337
A	ASP362-HIS374
A	ASP398-GLN410

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---