Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6XPV

Nucleoside Diphosphate Kinase from Aspergillus fumgiatus Af293 bound to dTDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0046872	molecular_function	metal ion binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0046872	molecular_function	metal ion binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0009142	biological_process	nucleoside triphosphate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0046872	molecular_function	metal ion binding
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005524	molecular_function	ATP binding
E	0006183	biological_process	GTP biosynthetic process
E	0006228	biological_process	UTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0009117	biological_process	nucleotide metabolic process
E	0009142	biological_process	nucleoside triphosphate biosynthetic process
E	0016301	molecular_function	kinase activity
E	0046872	molecular_function	metal ion binding
G	0004550	molecular_function	nucleoside diphosphate kinase activity
G	0005524	molecular_function	ATP binding
G	0006183	biological_process	GTP biosynthetic process
G	0006228	biological_process	UTP biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0009117	biological_process	nucleotide metabolic process
G	0009142	biological_process	nucleoside triphosphate biosynthetic process
G	0016301	molecular_function	kinase activity
G	0046872	molecular_function	metal ion binding
H	0004550	molecular_function	nucleoside diphosphate kinase activity
H	0005524	molecular_function	ATP binding
H	0006183	biological_process	GTP biosynthetic process
H	0006228	biological_process	UTP biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0009117	biological_process	nucleotide metabolic process
H	0009142	biological_process	nucleoside triphosphate biosynthetic process
H	0016301	molecular_function	kinase activity
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue TYD A 201

Chain	Residue
A	LYS11
A	PHE59
A	LEU63
A	ARG87
A	THR93
A	HOH313
A	HOH337
A	HOH368

site_id	AC2
Number of Residues	13
Details	binding site for residue TYD B 201

Chain	Residue
B	PHE59
B	LEU63
B	ARG87
B	THR93
B	HOH301
B	HOH304
B	HOH307
B	HOH309
B	HOH322
B	HOH339
B	HOH352
B	HOH355
B	LEU54

site_id	AC3
Number of Residues	12
Details	binding site for residue TYD C 201

Chain	Residue
C	LEU54
C	PHE59
C	LEU63
C	ARG87
C	THR93
C	HOH302
C	HOH305
C	HOH307
C	HOH309
C	HOH311
C	HOH335
C	HOH353

site_id	AC4
Number of Residues	14
Details	binding site for residue TYD E 201

Chain	Residue
E	LYS11
E	LEU54
E	PHE59
E	ARG87
E	THR93
E	HOH301
E	HOH302
E	HOH307
E	HOH315
E	HOH327
E	HOH335
E	HOH337
E	HOH348
E	HOH380

site_id	AC5
Number of Residues	15
Details	binding site for residue TYD G 201

Chain	Residue
G	LYS11
G	TYR51
G	LEU54
G	PHE59
G	LEU63
G	ARG87
G	THR93
G	HOH304
G	HOH307
G	HOH315
G	HOH320
G	HOH321
G	HOH331
G	HOH355
G	HOH389

site_id	AC6
Number of Residues	13
Details	binding site for residue TYD H 201

Chain	Residue
G	HOH312
H	LEU54
H	PHE59
H	LEU63
H	ARG87
H	THR93
H	VAL111
H	HOH301
H	HOH305
H	HOH306
H	HOH317
H	HOH324
H	HOH354

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NvcHGSDSV

Chain	Residue	Details
A	ASN114-VAL122

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000250

Chain	Residue	Details
A	HIS117
B	HIS117
C	HIS117
E	HIS117
G	HIS117
H	HIS117

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS11
B	THR93
B	ARG104
B	ASN114
C	LYS11
C	PHE59
C	ARG87
C	THR93
C	ARG104
C	ASN114
E	LYS11
A	PHE59
E	PHE59
E	ARG87
E	THR93
E	ARG104
E	ASN114
G	LYS11
G	PHE59
G	ARG87
G	THR93
G	ARG104
A	ARG87
G	ASN114
H	LYS11
H	PHE59
H	ARG87
H	THR93
H	ARG104
H	ASN114
A	THR93
A	ARG104
A	ASN114
B	LYS11
B	PHE59
B	ARG87

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)