6XPU
Nucleoside Diphosphate Kinase from Aspergillus fumgiatus Af293 bound to IDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0006228 | biological_process | UTP biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0006228 | biological_process | UTP biosynthetic process |
| B | 0006241 | biological_process | CTP biosynthetic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0006228 | biological_process | UTP biosynthetic process |
| C | 0006241 | biological_process | CTP biosynthetic process |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | IDP202 |
| A | HOH315 |
| A | HOH319 |
| A | HOH466 |
| A | HOH475 |
| A | HOH521 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue IDP A 202 |
| Chain | Residue |
| A | PHE59 |
| A | LEU63 |
| A | ARG87 |
| A | THR93 |
| A | VAL111 |
| A | GLY112 |
| A | ASN114 |
| A | MG201 |
| A | HOH303 |
| A | HOH306 |
| A | HOH310 |
| A | HOH315 |
| A | HOH319 |
| A | HOH321 |
| A | HOH328 |
| A | HOH335 |
| A | HOH371 |
| A | HOH438 |
| A | HOH444 |
| C | GLU151 |
| A | LYS11 |
| A | TYR51 |
| A | LEU54 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | ASP53 |
| B | IDP202 |
| B | HOH310 |
| B | HOH328 |
| B | HOH375 |
| B | HOH407 |
| B | HOH449 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue IDP B 202 |
| Chain | Residue |
| A | GLU151 |
| B | LYS11 |
| B | TYR51 |
| B | LEU54 |
| B | PHE59 |
| B | LEU63 |
| B | ARG87 |
| B | THR93 |
| B | VAL111 |
| B | ASN114 |
| B | MG201 |
| B | HOH310 |
| B | HOH312 |
| B | HOH315 |
| B | HOH320 |
| B | HOH325 |
| B | HOH328 |
| B | HOH375 |
| B | HOH391 |
| B | HOH442 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 201 |
| Chain | Residue |
| C | IDP202 |
| C | HOH324 |
| C | HOH347 |
| C | HOH351 |
| C | HOH405 |
| C | HOH465 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue IDP C 202 |
| Chain | Residue |
| B | GLU151 |
| C | LYS11 |
| C | TYR51 |
| C | LEU54 |
| C | PHE59 |
| C | LEU63 |
| C | ARG87 |
| C | THR93 |
| C | VAL111 |
| C | ASN114 |
| C | MG201 |
| C | HOH302 |
| C | HOH313 |
| C | HOH318 |
| C | HOH324 |
| C | HOH347 |
| C | HOH351 |
| C | HOH361 |
| C | HOH392 |
| C | HOH417 |
Functional Information from PROSITE/UniProt
| site_id | PS00469 |
| Number of Residues | 9 |
| Details | NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NvcHGSDSV |
| Chain | Residue | Details |
| A | ASN114-VAL122 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS117 | |
| B | HIS117 | |
| C | HIS117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS11 | |
| B | THR93 | |
| B | ARG104 | |
| B | ASN114 | |
| C | LYS11 | |
| C | PHE59 | |
| C | ARG87 | |
| C | THR93 | |
| C | ARG104 | |
| C | ASN114 | |
| A | PHE59 | |
| A | ARG87 | |
| A | THR93 | |
| A | ARG104 | |
| A | ASN114 | |
| B | LYS11 | |
| B | PHE59 | |
| B | ARG87 |
