6XPS
Nucleoside Diphosphate Kinase from Aspergillus fumgiatus Af293 bound to GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0006228 | biological_process | UTP biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0006228 | biological_process | UTP biosynthetic process |
| B | 0006241 | biological_process | CTP biosynthetic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0006228 | biological_process | UTP biosynthetic process |
| C | 0006241 | biological_process | CTP biosynthetic process |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GDP A 201 |
| Chain | Residue |
| A | LYS11 |
| A | MG202 |
| A | HOH305 |
| A | HOH321 |
| A | HOH327 |
| A | HOH328 |
| A | HOH331 |
| A | HOH340 |
| A | HOH349 |
| A | HOH352 |
| A | HOH369 |
| A | TYR51 |
| A | HOH375 |
| A | HOH382 |
| A | HOH406 |
| C | GLU151 |
| A | LEU54 |
| A | PHE59 |
| A | LEU63 |
| A | ARG87 |
| A | THR93 |
| A | VAL111 |
| A | ASN114 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | GDP201 |
| A | HOH349 |
| A | HOH369 |
| A | HOH382 |
| A | HOH388 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue GDP B 201 |
| Chain | Residue |
| A | GLU151 |
| B | LYS11 |
| B | TYR51 |
| B | LEU54 |
| B | PHE59 |
| B | LEU63 |
| B | ARG87 |
| B | THR93 |
| B | VAL111 |
| B | ASN114 |
| B | MG202 |
| B | HOH307 |
| B | HOH309 |
| B | HOH315 |
| B | HOH316 |
| B | HOH325 |
| B | HOH329 |
| B | HOH345 |
| B | HOH350 |
| B | HOH352 |
| B | HOH376 |
| B | HOH378 |
| B | HOH417 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | GDP201 |
| B | HOH304 |
| B | HOH325 |
| B | HOH352 |
| B | HOH395 |
| B | HOH457 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue GDP C 201 |
| Chain | Residue |
| B | GLU151 |
| C | LYS11 |
| C | TYR51 |
| C | LEU54 |
| C | PHE59 |
| C | LEU63 |
| C | ARG87 |
| C | THR93 |
| C | VAL111 |
| C | ASN114 |
| C | MG202 |
| C | HOH302 |
| C | HOH313 |
| C | HOH323 |
| C | HOH344 |
| C | HOH348 |
| C | HOH361 |
| C | HOH364 |
| C | HOH368 |
| C | HOH408 |
| C | HOH450 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 202 |
| Chain | Residue |
| C | GDP201 |
| C | HOH305 |
| C | HOH335 |
| C | HOH361 |
| C | HOH368 |
| C | HOH475 |
Functional Information from PROSITE/UniProt
| site_id | PS00469 |
| Number of Residues | 9 |
| Details | NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NvcHGSDSV |
| Chain | Residue | Details |
| A | ASN114-VAL122 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS117 | |
| B | HIS117 | |
| C | HIS117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS11 | |
| B | THR93 | |
| B | ARG104 | |
| B | ASN114 | |
| C | LYS11 | |
| C | PHE59 | |
| C | ARG87 | |
| C | THR93 | |
| C | ARG104 | |
| C | ASN114 | |
| A | PHE59 | |
| A | ARG87 | |
| A | THR93 | |
| A | ARG104 | |
| A | ASN114 | |
| B | LYS11 | |
| B | PHE59 | |
| B | ARG87 |
