6XPE
Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| A | CYS53 |
| B | HIS301 |
| B | HIS318 |
| B | GLN350 |
| B | GLU352 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | HIS137 |
| B | HIS345 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| B | ASP224 |
| B | HIS106 |
| B | ASP110 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | HIS52 |
| A | HIS54 |
| B | CYS361 |
| B | CYS364 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | HIS301 |
| A | HIS318 |
| A | GLN350 |
| A | GLU352 |
| B | CYS53 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 403 |
| Chain | Residue |
| A | CYS361 |
| A | CYS364 |
| B | HIS52 |
| B | HIS54 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 404 |
| Chain | Residue |
| A | HIS137 |
| A | HIS345 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 405 |
| Chain | Residue |
| A | HIS106 |
| A | ASP110 |
| A | ASP224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"16984975","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Topological domain: {"description":"Lumenal, vesicle","evidences":[{"source":"PubMed","id":"16984975","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Motif: {"description":"HCH Motif; seals regulatory zinc-binding pocket","evidences":[{"source":"PubMed","id":"32723473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"32723473","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XPE","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32723473","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XPE","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"32723473","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XPE","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
