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6XOS

CryoEM structure of human presequence protease in partial open state 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006508biological_processproteolysis
A0006626biological_processprotein targeting to mitochondrion
A0008047molecular_functionenzyme activator activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0016485biological_processprotein processing
A0046872molecular_functionmetal ion binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:24931469
ChainResidueDetails
AGLU107

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q9LJL3
ChainResidueDetails
AGLU180

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:24931469, ECO:0007744|PDB:4L3T, ECO:0007744|PDB:4NGE
ChainResidueDetails
AHIS104
AHIS108
AGLU205

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8K411
ChainResidueDetails
ALYS759
ALYS884

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8K411
ChainResidueDetails
ALYS770

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8K411
ChainResidueDetails
ALYS849
ALYS946

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PDB entries from 2024-11-20

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