6XOA
The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019082 | biological_process | viral protein processing |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019082 | biological_process | viral protein processing |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0019082 | biological_process | viral protein processing |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0019082 | biological_process | viral protein processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | LYS5 |
| A | GLN127 |
| B | LYS5 |
| B | GLN127 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 401 |
| Chain | Residue |
| C | ARG4 |
| C | LYS5 |
| D | LYS5 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 401 |
| Chain | Residue |
| D | LYS5 |
| D | TYR126 |
| D | GLN127 |
| C | LYS5 |
| C | TYR126 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291 |
| Chain | Residue | Details |
| A | HIS41 | |
| B | HIS41 | |
| C | HIS41 | |
| D | HIS41 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291 |
| Chain | Residue | Details |
| A | SER145 | |
| B | SER145 | |
| C | SER145 | |
| D | SER145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN306 | |
| B | GLN306 | |
| C | GLN306 | |
| D | GLN306 |
