6XOA
The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019082 | biological_process | viral protein processing |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019082 | biological_process | viral protein processing |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0019082 | biological_process | viral protein processing |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0019082 | biological_process | viral protein processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | LYS5 |
| A | GLN127 |
| B | LYS5 |
| B | GLN127 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 401 |
| Chain | Residue |
| C | ARG4 |
| C | LYS5 |
| D | LYS5 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 401 |
| Chain | Residue |
| D | LYS5 |
| D | TYR126 |
| D | GLN127 |
| C | LYS5 |
| C | TYR126 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1220 |
| Details | Domain: {"description":"Peptidase C30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile; for 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"39223933","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
