6XMY

Crystal Structure of 4-hydroxythreonine-4-phosphate dehydrogenase from Legionella pneumophila in complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0008615	biological_process	pyridoxine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0050570	molecular_function	4-hydroxythreonine-4-phosphate dehydrogenase activity
A	0050897	molecular_function	cobalt ion binding
A	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue NAD A 401

Chain	Residue
A	ILE14
A	THR242
A	SER288
A	HIS291
A	GLY292
A	THR293
A	ALA294
A	GLU296
A	ALA303
A	ASN304
A	EDO408
A	PRO114
A	HOH553
A	HOH598
A	HOH599
A	HOH627
A	HOH673
A	HOH680
A	HOH712
A	HOH719
A	VAL115
A	HIS116
A	LYS117
A	HIS130
A	HIS205
A	GLU208
A	PRO239

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 A 402

Chain	Residue
A	LYS117
A	GLY129
A	HIS130
A	THR131
A	MET145
A	HIS160
A	ASN277
A	ARG286
A	HOH509

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PO4 A 403

Chain	Residue
A	HIS-1
A	HIS-2
A	HIS0
A	SER59
A	PHE60
A	PRO73
A	HOH504
A	HOH513

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 404

Chain	Residue
A	ARG41
A	GLU44
A	VAL78
A	SER80

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 405

Chain	Residue
A	SER36
A	PRO77
A	VAL78
A	HOH562
A	HOH692

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 406

Chain	Residue
A	SER185
A	ASP189
A	MET318
A	HOH619
A	HOH634

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 407

Chain	Residue
A	PRO28
A	VAL29
A	SER59
A	PHE60
A	LYS61
A	THR68
A	HOH532

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 408

Chain	Residue
A	HIS205
A	NAD401
A	HOH537
A	HOH600
A	HOH622
A	HOH746

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 409

Chain	Residue
A	HIS183
A	HIS184
A	LYS187
A	HIS188

---

site_id	AD1
Number of Residues	6
Details	binding site for residue ZN A 410

Chain	Residue
A	HIS160
A	HIS205
A	HIS260
A	HOH590
A	HOH644
A	HOH706

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