6XMT
Structure of P5A-ATPase Spf1, BeF3-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005801 | cellular_component | cis-Golgi network |
| A | 0006874 | biological_process | intracellular calcium ion homeostasis |
| A | 0015031 | biological_process | protein transport |
| A | 0015662 | molecular_function | P-type ion transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019829 | molecular_function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| A | 0030026 | biological_process | intracellular manganese ion homeostasis |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0043335 | biological_process | protein unfolding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055092 | biological_process | sterol homeostasis |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0140358 | molecular_function | P-type transmembrane transporter activity |
| A | 0140567 | molecular_function | membrane protein dislocase activity |
| A | 0140569 | biological_process | extraction of mislocalized protein from ER membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue BEF A 1301 |
| Chain | Residue |
| A | GLY309 |
| A | ASP487 |
| A | THR489 |
| A | THR697 |
| A | LYS797 |
| A | ASN819 |
| A | MG1302 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1302 |
| Chain | Residue |
| A | ASP816 |
| A | GLY817 |
| A | BEF1301 |
| A | ASP487 |
| A | THR489 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 838 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | MET1-PRO27 | |
| A | TRP77-THR188 | |
| A | ARG247-ASP395 | |
| A | PHE465-VAL971 | |
| A | SER1036-ASN1055 | |
| A | GLN1122-ASN1133 | |
| A | MET1198-LYS1215 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | TRANSMEM: Helical; Name=TMa => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | TYR28-TYR43 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 49 |
| Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | PHE44-TRP56 | |
| A | PHE217 | |
| A | ARG426-ILE427 | |
| A | ALA1012-GLY1017 | |
| A | PRO1085-SER1099 | |
| A | THR1152-THR1168 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=TMb => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | THR57-ALA76 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=TM1 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | PHE189-GLU216 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM2 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | TRP218-PHE246 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=TM3 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | ASN396-GLY425 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | TRANSMEM: Helical; Name=TM4a => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | GLN428-VAL442 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=TM4b => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | GLU446-LYS464 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | TRANSMEM: Helical; Name=TM5 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | SER972-MET1011 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=TM6 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | ASP1018-ILE1035 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM7 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | VAL1056-GLU1084 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=TM8 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | LEU1100-TYR1121 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=TM9 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | LYS1134-ALA1151 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=TM10 => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | ASP1169-PHE1197 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000305|PubMed:22745129, ECO:0000305|PubMed:24392018, ECO:0000305|PubMed:30785834, ECO:0000305|PubMed:32353073 |
| Chain | Residue | Details |
| A | ASP487 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:32973005 |
| Chain | Residue | Details |
| A | ASP487 | |
| A | THR489 | |
| A | ARG634 | |
| A | ASP699 | |
| A | ASP816 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y2Q0 |
| Chain | Residue | Details |
| A | PHE582 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER324 | |
| A | SER936 |
