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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6XJX

MCU holocomplex in Low-calcium blocking state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006851biological_processmitochondrial calcium ion transmembrane transport
A0015292molecular_functionuniporter activity
A0019722biological_processcalcium-mediated signaling
A0032024biological_processpositive regulation of insulin secretion
A0034220biological_processmonoatomic ion transmembrane transport
A0034704cellular_componentcalcium channel complex
A0036444biological_processcalcium import into the mitochondrion
A0042593biological_processglucose homeostasis
A0043065biological_processpositive regulation of apoptotic process
A0051259biological_processprotein complex oligomerization
A0051560biological_processmitochondrial calcium ion homeostasis
A0051561biological_processpositive regulation of mitochondrial calcium ion concentration
A0070588biological_processcalcium ion transmembrane transport
A0072732biological_processcellular response to calcium ion starvation
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0090141biological_processpositive regulation of mitochondrial fission
A0090527biological_processobsolete actin filament reorganization
A1990246cellular_componentuniplex complex
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006851biological_processmitochondrial calcium ion transmembrane transport
B0030674molecular_functionprotein-macromolecule adaptor activity
B0036444biological_processcalcium import into the mitochondrion
B0051560biological_processmitochondrial calcium ion homeostasis
B0072732biological_processcellular response to calcium ion starvation
B0099103molecular_functionchannel activator activity
B1990246cellular_componentuniplex complex
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006851biological_processmitochondrial calcium ion transmembrane transport
C0015292molecular_functionuniporter activity
C0019722biological_processcalcium-mediated signaling
C0032024biological_processpositive regulation of insulin secretion
C0034220biological_processmonoatomic ion transmembrane transport
C0034704cellular_componentcalcium channel complex
C0036444biological_processcalcium import into the mitochondrion
C0042593biological_processglucose homeostasis
C0043065biological_processpositive regulation of apoptotic process
C0051259biological_processprotein complex oligomerization
C0051560biological_processmitochondrial calcium ion homeostasis
C0051561biological_processpositive regulation of mitochondrial calcium ion concentration
C0070588biological_processcalcium ion transmembrane transport
C0072732biological_processcellular response to calcium ion starvation
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0090141biological_processpositive regulation of mitochondrial fission
C0090527biological_processobsolete actin filament reorganization
C1990246cellular_componentuniplex complex
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006851biological_processmitochondrial calcium ion transmembrane transport
D0030674molecular_functionprotein-macromolecule adaptor activity
D0036444biological_processcalcium import into the mitochondrion
D0051560biological_processmitochondrial calcium ion homeostasis
D0072732biological_processcellular response to calcium ion starvation
D0099103molecular_functionchannel activator activity
D1990246cellular_componentuniplex complex
E0005262molecular_functioncalcium channel activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005743cellular_componentmitochondrial inner membrane
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0006851biological_processmitochondrial calcium ion transmembrane transport
E0015292molecular_functionuniporter activity
E0019722biological_processcalcium-mediated signaling
E0032024biological_processpositive regulation of insulin secretion
E0034220biological_processmonoatomic ion transmembrane transport
E0034704cellular_componentcalcium channel complex
E0036444biological_processcalcium import into the mitochondrion
E0042593biological_processglucose homeostasis
E0043065biological_processpositive regulation of apoptotic process
E0051259biological_processprotein complex oligomerization
E0051560biological_processmitochondrial calcium ion homeostasis
E0051561biological_processpositive regulation of mitochondrial calcium ion concentration
E0070588biological_processcalcium ion transmembrane transport
E0072732biological_processcellular response to calcium ion starvation
E0090023biological_processpositive regulation of neutrophil chemotaxis
E0090141biological_processpositive regulation of mitochondrial fission
E0090527biological_processobsolete actin filament reorganization
E1990246cellular_componentuniplex complex
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005743cellular_componentmitochondrial inner membrane
F0005759cellular_componentmitochondrial matrix
F0006811biological_processmonoatomic ion transport
F0006816biological_processcalcium ion transport
F0006851biological_processmitochondrial calcium ion transmembrane transport
F0030674molecular_functionprotein-macromolecule adaptor activity
F0036444biological_processcalcium import into the mitochondrion
F0051560biological_processmitochondrial calcium ion homeostasis
F0072732biological_processcellular response to calcium ion starvation
F0099103molecular_functionchannel activator activity
F1990246cellular_componentuniplex complex
G0005262molecular_functioncalcium channel activity
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0006851biological_processmitochondrial calcium ion transmembrane transport
G0015292molecular_functionuniporter activity
G0019722biological_processcalcium-mediated signaling
G0032024biological_processpositive regulation of insulin secretion
G0034220biological_processmonoatomic ion transmembrane transport
G0034704cellular_componentcalcium channel complex
G0036444biological_processcalcium import into the mitochondrion
G0042593biological_processglucose homeostasis
G0043065biological_processpositive regulation of apoptotic process
G0051259biological_processprotein complex oligomerization
G0051560biological_processmitochondrial calcium ion homeostasis
G0051561biological_processpositive regulation of mitochondrial calcium ion concentration
G0070588biological_processcalcium ion transmembrane transport
G0072732biological_processcellular response to calcium ion starvation
G0090023biological_processpositive regulation of neutrophil chemotaxis
G0090141biological_processpositive regulation of mitochondrial fission
G0090527biological_processobsolete actin filament reorganization
G1990246cellular_componentuniplex complex
H0005515molecular_functionprotein binding
H0005739cellular_componentmitochondrion
H0005743cellular_componentmitochondrial inner membrane
H0005759cellular_componentmitochondrial matrix
H0006811biological_processmonoatomic ion transport
H0006816biological_processcalcium ion transport
H0006851biological_processmitochondrial calcium ion transmembrane transport
H0030674molecular_functionprotein-macromolecule adaptor activity
H0036444biological_processcalcium import into the mitochondrion
H0051560biological_processmitochondrial calcium ion homeostasis
H0072732biological_processcellular response to calcium ion starvation
H0099103molecular_functionchannel activator activity
H1990246cellular_componentuniplex complex
Q0005509molecular_functioncalcium ion binding
Q0005515molecular_functionprotein binding
Q0005739cellular_componentmitochondrion
Q0005743cellular_componentmitochondrial inner membrane
Q0005758cellular_componentmitochondrial intermembrane space
Q0006811biological_processmonoatomic ion transport
Q0006816biological_processcalcium ion transport
Q0006851biological_processmitochondrial calcium ion transmembrane transport
Q0006952biological_processdefense response
Q0019855molecular_functioncalcium channel inhibitor activity
Q0031966cellular_componentmitochondrial membrane
Q0034704cellular_componentcalcium channel complex
Q0036444biological_processcalcium import into the mitochondrion
Q0042802molecular_functionidentical protein binding
Q0044284cellular_componentmitochondrial crista junction
Q0046872molecular_functionmetal ion binding
Q0046982molecular_functionprotein heterodimerization activity
Q0051260biological_processprotein homooligomerization
Q0051560biological_processmitochondrial calcium ion homeostasis
Q0051561biological_processpositive regulation of mitochondrial calcium ion concentration
Q0061891molecular_functioncalcium ion sensor activity
Q0070509biological_processcalcium ion import
Q0071277biological_processcellular response to calcium ion
Q0072732biological_processcellular response to calcium ion starvation
Q1900069biological_processregulation of cellular hyperosmotic salinity response
Q1903852biological_processpositive regulation of cristae formation
Q1990246cellular_componentuniplex complex
R0005246molecular_functioncalcium channel regulator activity
R0005509molecular_functioncalcium ion binding
R0005515molecular_functionprotein binding
R0005739cellular_componentmitochondrion
R0005743cellular_componentmitochondrial inner membrane
R0005758cellular_componentmitochondrial intermembrane space
R0006851biological_processmitochondrial calcium ion transmembrane transport
R0034704cellular_componentcalcium channel complex
R0036444biological_processcalcium import into the mitochondrion
R0046982molecular_functionprotein heterodimerization activity
R0051560biological_processmitochondrial calcium ion homeostasis
R0051561biological_processpositive regulation of mitochondrial calcium ion concentration
R0051562biological_processnegative regulation of mitochondrial calcium ion concentration
R0061891molecular_functioncalcium ion sensor activity
R0071277biological_processcellular response to calcium ion
R1990246cellular_componentuniplex complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF
ChainResidueDetails
QASP231-PHE243
QASP421-PHE433
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues244
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues24
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsRegion: {"description":"Juxtamembrane helix","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33296646","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues236
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues32
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UMR5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues44
DetailsTopological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27642048","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues16
DetailsMotif: {"description":"GXXXX[G/A/S]","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues35
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues35
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues7
DetailsRegion: {"description":"K/R-ring","evidences":[{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues10
DetailsRegion: {"description":"C-helix region","evidences":[{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VCX5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"27642082","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues35
DetailsDomain: {"description":"EF-hand 3; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues35
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-03-11

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