6XIB

PCSK9(deltaCRD) in complex with cyclic peptide 30

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 201

Chain	Residue
A	THR63
A	PHE64
A	HOH311
A	HOH342
B	SER178
B	LEU179
B	VAL280
B	GLY281

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site_id	AC2
Number of Residues	14
Details	binding site for residues FTR I 5 and FTR I 6

Chain	Residue
A	ALA100
A	GLN101
B	ILE369
B	ASP374
B	CYS378
B	PHE379
B	VAL380
B	SER381
I	GLY4
I	ASP7
I	HIS8
I	HOH105
I	HOH107
A	ARG97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240

Chain	Residue	Details
B	ASP186
B	HIS226
B	SER386

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035

Chain	Residue	Details
B	ARG218

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER47

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