6XI5

Crystal structure of human N-acetylserotonin O-methyltransferase-like protein soaked with PDHPTAO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 301

Chain	Residue
A	GLU147
A	LYS149
A	HIS190

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site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 B 301

Chain	Residue
B	LYS48
B	PHE51
B	ALA52
B	THR53
B	PRO54
B	ILE97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor; for pyrophosphatase activity => ECO:0000305|PubMed:24210219

Chain	Residue	Details
B	ASP88
A	ASP88

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site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Important for substrate specificity; for pyrophosphatase activity => ECO:0000305|PubMed:24210219

Chain	Residue	Details
B	ARG23
B	THR89
B	GLN179
A	ARG23
A	THR89
A	GLN179

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER21
B	SER21

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER228
A	SER228

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR234
B	THR234

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER239
B	SER239

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