6XGS
Crystal Structure of Dihydrodipicolinate synthase (DHDPS) from Brucella suis 1330
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0009085 | biological_process | L-lysine biosynthetic process |
| A | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0044281 | biological_process | small molecule metabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| B | 0009085 | biological_process | L-lysine biosynthetic process |
| B | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0044281 | biological_process | small molecule metabolic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| C | 0009085 | biological_process | L-lysine biosynthetic process |
| C | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019877 | biological_process | diaminopimelate biosynthetic process |
| C | 0044281 | biological_process | small molecule metabolic process |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| D | 0009085 | biological_process | L-lysine biosynthetic process |
| D | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019877 | biological_process | diaminopimelate biosynthetic process |
| D | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue CIT A 401 |
| Chain | Residue |
| A | TYR133 |
| A | HOH504 |
| A | HOH570 |
| A | ILE135 |
| A | ARG138 |
| A | LYS162 |
| A | GLY187 |
| A | GLU188 |
| A | VAL206 |
| A | PHE245 |
| A | ASN249 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | ARG268 |
| A | SER269 |
| A | HOH540 |
| B | VAL83 |
| B | ARG121 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| A | VAL83 |
| A | ARG121 |
| B | ARG268 |
| B | SER269 |
| B | HOH436 |
| B | HOH447 |
| B | HOH473 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue CIT B 302 |
| Chain | Residue |
| B | ILE135 |
| B | ARG138 |
| B | GLY187 |
| B | GLU188 |
| B | VAL206 |
| B | PHE245 |
| B | ASN249 |
| B | HOH425 |
| B | HOH432 |
| B | HOH455 |
| B | HOH466 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 303 |
| Chain | Residue |
| A | LYS281 |
| B | ARG259 |
| B | ILE292 |
| B | ASN293 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue CIT C 401 |
| Chain | Residue |
| C | TYR133 |
| C | ARG138 |
| C | GLY187 |
| C | GLU188 |
| C | VAL206 |
| C | PHE245 |
| C | HOH502 |
| C | HOH508 |
| C | HOH522 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 C 402 |
| Chain | Residue |
| C | ARG268 |
| C | SER269 |
| C | HOH520 |
| D | VAL83 |
| D | ARG121 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 301 |
| Chain | Residue |
| C | VAL83 |
| C | ARG121 |
| D | ARG268 |
| D | SER269 |
| D | HOH434 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue CIT D 302 |
| Chain | Residue |
| D | THR44 |
| D | ILE135 |
| D | ARG138 |
| D | LYS162 |
| D | GLY187 |
| D | GLU188 |
| D | VAL206 |
| D | PHE245 |
| D | ASN249 |
| D | HOH415 |
| D | HOH438 |
| D | HOH464 |
Functional Information from PROSITE/UniProt
| site_id | PS00666 |
| Number of Residues | 32 |
| Details | DHDPS_2 Dihydrodipicolinate synthase signature 2. YNIPgrSiidMtpetmgalvrdcknIvGVKDA |
| Chain | Residue | Details |
| A | TYR133-ALA164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Site: {"description":"Part of a proton relay during catalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
