6XFS

Class C beta-lactamase from Escherichia coli in complex with Tazobactam

Replaces:  6WA7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0008800	molecular_function	beta-lactamase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0008800	molecular_function	beta-lactamase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030288	cellular_component	outer membrane-bounded periplasmic space

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue TBE A 501

Chain	Residue
A	SER91
A	GLN147
A	TYR248
A	ALA345
A	THR346

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 502

Chain	Residue
A	GLU299
A	LYS342
A	THR343

---

site_id	AC3
Number of Residues	1
Details	binding site for residue EDO A 503

Chain	Residue
A	PRO192

---

site_id	AC4
Number of Residues	8
Details	binding site for residue PGE B 502

Chain	Residue
B	LYS326
B	PRO327
B	THR329
B	HOH601
C	PRO115
C	GLY130
C	THR132
C	HIS135

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO B 503

Chain	Residue
B	SER314
B	HIS341
B	LYS342
B	THR343
B	HOH615

---

site_id	AC6
Number of Residues	6
Details	binding site for residue PEG C 401

Chain	Residue
C	TYR177
C	GLU299
C	SER314
C	HIS341
C	LYS342
C	THR343

---

site_id	AC7
Number of Residues	8
Details	binding site for residue PGE D 502

Chain	Residue
D	SER91
D	GLU299
D	SER314
D	ASN316
D	ALA319
D	THR343
D	ASN373
D	TBE501

---

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO D 503

Chain	Residue
D	ASN36
D	HIS40

---

site_id	AC9
Number of Residues	15
Details	binding site for Di-peptide TBE B 501 and SER B 91

Chain	Residue
B	LEU89
B	GLY90
B	VAL92
B	SER93
B	LYS94
B	GLN147
B	TYR177
B	ALA247
B	TYR248
B	LYS342
B	THR343
B	GLY344
B	ALA345
B	THR346
B	GLY347

---

site_id	AD1
Number of Residues	16
Details	binding site for Di-peptide TBE C 402 and SER C 91

Chain	Residue
C	LEU89
C	GLY90
C	VAL92
C	SER93
C	LYS94
C	GLN147
C	TYR177
C	ASN179
C	ALA247
C	TYR248
C	LYS342
C	THR343
C	GLY344
C	ALA345
C	THR346
C	GLY347

---

site_id	AD2
Number of Residues	16
Details	binding site for Di-peptide TBE D 501 and SER D 91

Chain	Residue
D	LEU89
D	GLY90
D	VAL92
D	SER93
D	LYS94
D	GLN147
D	TYR177
D	ALA247
D	TYR248
D	LYS342
D	THR343
D	GLY344
D	ALA345
D	THR346
D	GLY347
D	PGE502

---

Functional Information from PROSITE/UniProt

site_id	PS00336
Number of Residues	8
Details	BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSVSK

Chain	Residue	Details
A	PHE87-LYS94

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10102, ECO:0000269|PubMed:6795623

Chain	Residue	Details
A	SER91
B	SER91
C	SER91
D	SER91

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR177
B	TYR177
C	TYR177
D	TYR177

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS342
B	LYS342
C	LYS342
D	LYS342

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