6XEW

Structure of Serratia marcescens 2,3-butanediol dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	binding site for residue NAD A 301

Chain	Residue
A	GLY12
A	ASN87
A	ALA88
A	GLY89
A	VAL90
A	VAL110
A	THR136
A	ALA137
A	SER138
A	TYR151
A	LYS155
A	ASN15
A	PRO181
A	SER182
A	LEU183
A	VAL184
A	THR186
A	MET188
A	THR189
A	HBR303
A	HBS304
A	HOH455
A	GLY16
A	HOH489
A	HOH516
A	HOH518
A	HOH522
A	MET17
A	ASP36
A	TRP37
A	ILE59
A	ASP60
A	VAL61

---

site_id	AC2
Number of Residues	17
Details	binding site for residue NAD A 302

Chain	Residue
A	TRP37
A	ALA38
A	LYS39
A	ARG105
A	ASP113
A	ASN187
A	HOH403
A	HOH413
A	HOH418
A	HOH443
A	HOH452
A	HOH456
A	HOH503
B	HIS64
B	ARG105
B	HOH436
B	HOH454

---

site_id	AC3
Number of Residues	21
Details	binding site for residue ADP B 301

Chain	Residue
A	GLY191
A	PRO193
A	HOH531
A	HOH539
B	GLY12
B	GLY14
B	ASN15
B	ASP36
B	TRP37
B	ILE59
B	ASP60
B	VAL61
B	ALA88
B	GLY89
B	VAL110
B	HOH401
B	HOH402
B	HOH403
B	HOH404
B	HOH476
B	HOH500

---

site_id	AC4
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

site_id	AC5
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

site_id	AC6
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

site_id	AC7
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460
A	SER138

---

site_id	AC8
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

site_id	AC9
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

site_id	AD1
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

site_id	AD2
Number of Residues	9
Details	binding site for residues HBR A 303 and HBS A 304

Chain	Residue
A	SER138
A	SER140
A	TYR151
A	PRO181
A	SER182
A	MET188
A	GLN247
A	NAD301
A	HOH460

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvsglggdwgAayYCAAKGAVvNLTrAMA

Chain	Residue	Details
A	SER138-ALA166

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33292448","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VSP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XEX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33292448","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XEW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---