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6XCI

Structure of NDM-1 in complex with macrocycle inhibitor NDM1i-3D

Functional Information from GO Data
ChainGOidnamespacecontents
A0008800molecular_functionbeta-lactamase activity
A0016787molecular_functionhydrolase activity
A0017001biological_processantibiotic catabolic process
A0042597cellular_componentperiplasmic space
A0046677biological_processresponse to antibiotic
A0046872molecular_functionmetal ion binding
B0008800molecular_functionbeta-lactamase activity
B0016787molecular_functionhydrolase activity
B0017001biological_processantibiotic catabolic process
B0042597cellular_componentperiplasmic space
B0046677biological_processresponse to antibiotic
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue ACT B 301
ChainResidue
BHIS122
BASP124
BASN220
BZN302
BCD303
BHOH404
BHOH530

site_idAC2
Number of Residues5
Detailsbinding site for residue ZN B 302
ChainResidue
BHIS189
BACT301
BHOH404
BHIS120
BHIS122

site_idAC3
Number of Residues6
Detailsbinding site for residue CD B 303
ChainResidue
BASP124
BCYS208
BHIS250
BACT301
BHOH404
BHOH556

site_idAC4
Number of Residues4
Detailsbinding site for residue CD B 304
ChainResidue
AGLU227
BGLU152
BASP223
BHOH554

site_idAC5
Number of Residues4
Detailsbinding site for residue CD B 305
ChainResidue
AGLU152
AASP223
AHOH547
BGLU227

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN A 301
ChainResidue
AHIS120
AHIS122
AHIS189
HHOH101

site_idAC7
Number of Residues6
Detailsbinding site for residue CD A 302
ChainResidue
AASP124
ACYS208
AHIS250
AHOH545
HGLU5
HHOH101

site_idAC8
Number of Residues12
Detailsbinding site for ? chain H
ChainResidue
AMET67
APRO68
APHE70
AVAL73
AASP124
AGLY219
AASN220
AHIS250
ACD302
BGLY71
BLYS216
HHOH101

227111

PDB entries from 2024-11-06

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