6XCF
Structure of the C. botulinum neurotoxin serotype A light chain protease in complex with noncovalent inhibitor 59
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue UZP A 601 |
Chain | Residue |
A | VAL70 |
A | GLU262 |
A | ARG363 |
A | TYR366 |
A | ASP370 |
A | VAL373 |
A | ZN602 |
A | HOH796 |
A | HOH827 |
A | HOH885 |
A | ILE161 |
A | GLN162 |
A | PHE163 |
A | PHE192 |
A | PHE194 |
A | HIS223 |
A | GLU224 |
A | HIS227 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 602 |
Chain | Residue |
A | HIS223 |
A | HIS227 |
A | GLU262 |
A | UZP601 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLAHELIHAG |
Chain | Residue | Details |
A | THR220-GLY229 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:10694409 |
Chain | Residue | Details |
A | GLU224 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15592454, ECO:0000269|PubMed:19351593, ECO:0007744|PDB:1XTF, ECO:0007744|PDB:1XTG, ECO:0007744|PDB:2W2D, ECO:0007744|PDB:3V0A, ECO:0007744|PDB:3V0B |
Chain | Residue | Details |
A | HIS223 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15592454, ECO:0000269|PubMed:19351593, ECO:0000305|PubMed:7578132, ECO:0007744|PDB:1XTF, ECO:0007744|PDB:1XTG, ECO:0007744|PDB:2W2D, ECO:0007744|PDB:3V0A, ECO:0007744|PDB:3V0B |
Chain | Residue | Details |
A | HIS227 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15592454, ECO:0000269|PubMed:19351593, ECO:0000305|PubMed:11700044, ECO:0007744|PDB:1XTF, ECO:0007744|PDB:1XTG, ECO:0007744|PDB:2W2D, ECO:0007744|PDB:3V0A, ECO:0007744|PDB:3V0B |
Chain | Residue | Details |
A | GLU262 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:11827515 |
Chain | Residue | Details |
A | ARG363 | |
A | TYR366 |