6XBO
X-ray crystal structure of the mouse CMP-Sialic acid transporter in complex with 5-methyl CMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005456 | molecular_function | CMP-N-acetylneuraminate transmembrane transporter activity |
| A | 0006054 | biological_process | N-acetylneuraminate metabolic process |
| A | 0015165 | molecular_function | pyrimidine nucleotide-sugar transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015782 | biological_process | CMP-N-acetylneuraminate transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0090481 | biological_process | pyrimidine nucleotide-sugar transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue 5MC A 401 |
| Chain | Residue |
| A | LYS55 |
| A | MET213 |
| A | TYR214 |
| A | GLY257 |
| A | THR260 |
| A | SER261 |
| A | LYS272 |
| A | HOH526 |
| A | HOH531 |
| A | HOH545 |
| A | HOH591 |
| A | TYR98 |
| A | HOH599 |
| A | GLN101 |
| A | ASN102 |
| A | TYR121 |
| A | LYS124 |
| A | SER188 |
| A | PHE195 |
| A | ASN210 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue OLC A 402 |
| Chain | Residue |
| A | GLY237 |
| A | PHE238 |
| A | ILE295 |
| A | LEU297 |
| A | OLC407 |
| A | HOH503 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 403 |
| Chain | Residue |
| A | ASN103 |
| A | MET104 |
| A | SER228 |
| A | OLC410 |
| A | HOH519 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 404 |
| Chain | Residue |
| A | LEU17 |
| A | MET271 |
| A | PHE274 |
| A | SER275 |
| A | LEU282 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 405 |
| Chain | Residue |
| A | ALA89 |
| A | LYS90 |
| A | SER92 |
| A | LEU96 |
| A | TYR194 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 406 |
| Chain | Residue |
| A | THR156 |
| A | TRP160 |
| A | TYR226 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 407 |
| Chain | Residue |
| A | PHE239 |
| A | GLN294 |
| A | ILE295 |
| A | OLC402 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 408 |
| Chain | Residue |
| A | PRO85 |
| A | LYS86 |
| A | SER92 |
| A | TYR311 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 409 |
| Chain | Residue |
| A | VAL169 |
| A | ASN173 |
| A | LEU175 |
| A | LEU176 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 410 |
| Chain | Residue |
| A | MET104 |
| A | LEU176 |
| A | ILE183 |
| A | OLC403 |
| A | HOH584 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 411 |
| Chain | Residue |
| A | LEU134 |
| A | MET135 |
| A | OLC412 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 412 |
| Chain | Residue |
| A | LYS197 |
| A | OLC411 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue OLC A 413 |
| Chain | Residue |
| A | ILE310 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 414 |
| Chain | Residue |
| A | LYS74 |
| A | VAL81 |
| A | HOH573 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue 2PE A 415 |
| Chain | Residue |
| A | ALA75 |
| A | LEU199 |
| A | SER202 |
| A | THR204 |
| A | LYS265 |
| A | TYR266 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue 2PE A 416 |
| Chain | Residue |
| A | LEU70 |
| A | LYS74 |
| A | TYR245 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 188 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30985278","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"30985278","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 45 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30985278","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30985278","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OH3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
