6XAA

SARS CoV-2 PLpro in complex with ubiquitin propargylamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS189
A	CYS192
A	CYS224
A	CYS226

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Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189-CYS226

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:32726803

Chain	Residue	Details
A	CYS111

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	HIS272
A	ASP286

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189
A	CYS192
A	CYS224
A	CYS226

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