6X9K

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1701

Chain	Residue
A	CYS1476
A	CYS1478
A	CYS1485
A	HIS1502

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1702

Chain	Residue
A	HIS793
A	CYS820
A	CYS893
A	CYS896

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 1703

Chain	Residue
A	TRP1395
A	PHE1396
A	GLN1399
A	GLY1305

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 1704

Chain	Residue
A	ASP810
A	GLU813
A	ARG1285
A	ARG1289
A	EDO1705

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 1705

Chain	Residue
A	ASP810
A	LYS837
A	PHE864
A	GLN866
A	ARG1289
A	EDO1704

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 1706

Chain	Residue
A	ALA1033
A	HIS1036

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 1707

Chain	Residue
A	ILE931
A	GLY1058
A	ARG1059
A	ASN1081
A	ARG1356
A	HOH1864

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 1708

Chain	Residue
A	GLY1380
A	ALA1381
A	SER1382
A	CYS1414

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EDO A 1709

Chain	Residue
A	PRO988
A	GLN1303
A	HIS1332
A	VAL1333
A	PHE1334
A	LEU1357
A	SER1359

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 1710

Chain	Residue
A	PRO1225
A	CYS1226
A	GLN1227
A	SER1246
A	LEU1247

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 1711

Chain	Residue
A	GLY1215
A	VAL1217
A	TYR1258
A	ARG1259
A	HOH1812

---

site_id	AD3
Number of Residues	8
Details	binding site for residue UXM C 101

Chain	Residue
A	HIS1507
A	TRP1510
A	LYS1535
C	5CM6
C	DG7
D	PYO18
D	DG19
D	DG20

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS

Chain	Residue	Details
A	GLU1218-SER1230

---

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI

Chain	Residue	Details
A	ARG1574-ILE1592

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	ZN_FING: CXXC-type => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	GLY982-HIS1028

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	THR1562

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	VAL750
A	ALA754

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	LYS1003
A	ASN1006
A	TYR1022
A	THR1027
A	GLU989
A	ARG992
A	ARG995
A	PHE1000

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P13864

Chain	Residue	Details
A	GLY1482
A	ASP1486
A	THR1526

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA

Chain	Residue	Details
A	VAL1527
A	GLY1504

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Important for activity => ECO:0000250

Chain	Residue	Details
A	MET845

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ARG730

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR885
A	LYS1214
A	VAL734

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13864

Chain	Residue	Details
A	MET845

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	VAL1050

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336

Chain	Residue	Details
A	LEU1068

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21947282

Chain	Residue	Details
A	GLN1227
A	GLN1293
A	GLY1297
A	ARG1311
A	GLY1390
A	PHE1085

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21947282, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	SER1447
A	GLY1449
A	MET1451

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by EHMT2 => ECO:0000269|PubMed:21947282

Chain	Residue	Details
A	ARG1453

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P13864

Chain	Residue	Details
A	TYR1457
A	LEU1455

---