6X9F
Pseudomonas aeruginosa MurC with AZ8074
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0051301 | biological_process | cell division |
| A | 0071555 | biological_process | cell wall organization |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0016881 | molecular_function | acid-amino acid ligase activity |
| B | 0051301 | biological_process | cell division |
| B | 0071555 | biological_process | cell wall organization |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008360 | biological_process | regulation of cell shape |
| C | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009252 | biological_process | peptidoglycan biosynthetic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0016881 | molecular_function | acid-amino acid ligase activity |
| C | 0051301 | biological_process | cell division |
| C | 0071555 | biological_process | cell wall organization |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008360 | biological_process | regulation of cell shape |
| D | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009252 | biological_process | peptidoglycan biosynthetic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0016881 | molecular_function | acid-amino acid ligase activity |
| D | 0051301 | biological_process | cell division |
| D | 0071555 | biological_process | cell wall organization |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008360 | biological_process | regulation of cell shape |
| E | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0009252 | biological_process | peptidoglycan biosynthetic process |
| E | 0016874 | molecular_function | ligase activity |
| E | 0016881 | molecular_function | acid-amino acid ligase activity |
| E | 0051301 | biological_process | cell division |
| E | 0071555 | biological_process | cell wall organization |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008360 | biological_process | regulation of cell shape |
| F | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0009252 | biological_process | peptidoglycan biosynthetic process |
| F | 0016874 | molecular_function | ligase activity |
| F | 0016881 | molecular_function | acid-amino acid ligase activity |
| F | 0051301 | biological_process | cell division |
| F | 0071555 | biological_process | cell wall organization |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0008360 | biological_process | regulation of cell shape |
| G | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0009252 | biological_process | peptidoglycan biosynthetic process |
| G | 0016874 | molecular_function | ligase activity |
| G | 0016881 | molecular_function | acid-amino acid ligase activity |
| G | 0051301 | biological_process | cell division |
| G | 0071555 | biological_process | cell wall organization |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0008360 | biological_process | regulation of cell shape |
| H | 0008763 | molecular_function | UDP-N-acetylmuramate-L-alanine ligase activity |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0009252 | biological_process | peptidoglycan biosynthetic process |
| H | 0016874 | molecular_function | ligase activity |
| H | 0016881 | molecular_function | acid-amino acid ligase activity |
| H | 0051301 | biological_process | cell division |
| H | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue UXP A 501 |
| Chain | Residue |
| A | HIS117 |
| C | EDO502 |
| A | GLY118 |
| A | THR182 |
| A | ASN183 |
| A | CYS219 |
| A | TYR239 |
| A | HIS281 |
| A | LEU284 |
| A | ASN285 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | PRO266 |
| A | VAL291 |
| A | ASP295 |
| A | HOH602 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | PRO96 |
| A | GLU99 |
| A | HIS173 |
| G | HIS208 |
| G | ARG234 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ASP221 |
| A | LEU280 |
| A | LEU284 |
| C | ASP222 |
| C | PRO223 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | PRO270 |
| A | LEU271 |
| A | ASP272 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | ALA19 |
| A | GLY20 |
| A | CYS22 |
| A | GLY23 |
| A | LEU145 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 507 |
| Chain | Residue |
| A | LEU135 |
| A | ARG158 |
| A | TYR159 |
| A | GLU296 |
| A | GLY297 |
| A | ILE298 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue UXP B 501 |
| Chain | Residue |
| B | GLY118 |
| B | THR182 |
| B | ASN183 |
| B | CYS219 |
| B | TYR239 |
| B | HIS281 |
| B | LEU284 |
| B | ASN285 |
| H | HOH603 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | ARG108 |
| B | ALA156 |
| B | ARG158 |
| B | HOH622 |
| D | HOH629 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | PRO96 |
| B | GLU99 |
| E | HIS208 |
| E | ARG234 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | HIS109 |
| B | ARG158 |
| B | TYR159 |
| B | GLU296 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ASP221 |
| B | LEU280 |
| B | LEU284 |
| H | ILE184 |
| H | ASP222 |
| H | PRO223 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | PRO270 |
| B | LEU271 |
| B | ASP272 |
| B | HOH625 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | ALA19 |
| B | GLY23 |
| B | ARG144 |
| B | LEU145 |
| B | HOH644 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 508 |
| Chain | Residue |
| B | ARG226 |
| B | THR238 |
| B | ASP244 |
| E | ARG91 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue DMS B 509 |
| Chain | Residue |
| B | LEU135 |
| B | ARG158 |
| B | GLU296 |
| B | GLY297 |
| B | HOH613 |
| D | HOH645 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 510 |
| Chain | Residue |
| B | PRO93 |
| B | VAL94 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue DMS B 511 |
| Chain | Residue |
| B | VAL220 |
| B | ASP221 |
| B | PRO223 |
| B | ARG226 |
| H | VAL220 |
| H | ASP221 |
| H | PRO223 |
| H | ARG226 |
| H | HOH636 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 512 |
| Chain | Residue |
| B | ARG9 |
| B | LEU31 |
| B | TYR33 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue UXP C 501 |
| Chain | Residue |
| C | HIS117 |
| C | GLY118 |
| C | THR182 |
| C | ASN183 |
| C | CYS219 |
| C | TYR239 |
| C | HIS281 |
| C | LEU284 |
| C | ASN285 |
| C | EDO502 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| A | PRO223 |
| A | UXP501 |
| C | ASP221 |
| C | LEU280 |
| C | LEU284 |
| C | UXP501 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| A | VAL220 |
| A | ASP221 |
| A | ARG226 |
| A | HOH654 |
| C | VAL220 |
| C | ASP221 |
| C | PRO223 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 504 |
| Chain | Residue |
| C | THR238 |
| C | ASP244 |
| C | ALA245 |
| D | ARG91 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 505 |
| Chain | Residue |
| A | ASN251 |
| C | PHE196 |
| C | ASN197 |
| C | LYS200 |
| C | GLU227 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 506 |
| Chain | Residue |
| A | PHE196 |
| A | ASN197 |
| A | LYS200 |
| A | GLU227 |
| C | ASN251 |
| C | ILE252 |
| C | HOH658 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue UXP D 501 |
| Chain | Residue |
| D | HIS117 |
| D | GLY118 |
| D | THR182 |
| D | ASN183 |
| D | CYS219 |
| D | TYR239 |
| D | HIS281 |
| D | LEU284 |
| D | ASN285 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| C | HIS208 |
| C | ARG234 |
| D | PRO96 |
| D | GLU99 |
| D | HIS173 |
| D | HOH643 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| D | PRO270 |
| D | ASP272 |
| D | HOH631 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 504 |
| Chain | Residue |
| D | PRO266 |
| D | ASP295 |
| D | HOH615 |
| D | HOH616 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 505 |
| Chain | Residue |
| D | SER124 |
| D | ALA127 |
| D | PHE139 |
| D | PHE310 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue DMS D 506 |
| Chain | Residue |
| D | ARG158 |
| D | TYR159 |
| D | GLU296 |
| D | GLY297 |
| D | ILE298 |
| D | HOH603 |
| site_id | AF5 |
| Number of Residues | 8 |
| Details | binding site for residue DMS D 507 |
| Chain | Residue |
| D | VAL220 |
| D | ASP221 |
| D | ASP222 |
| D | PRO223 |
| D | ARG226 |
| G | VAL220 |
| G | ASP221 |
| G | PRO223 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 508 |
| Chain | Residue |
| D | VAL94 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue UXP E 501 |
| Chain | Residue |
| E | GLY118 |
| E | THR182 |
| E | ASN183 |
| E | CYS219 |
| E | TYR239 |
| E | HIS281 |
| E | LEU284 |
| E | ASN285 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO E 502 |
| Chain | Residue |
| E | HOH633 |
| F | ASP244 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 503 |
| Chain | Residue |
| E | ASN197 |
| E | LYS200 |
| E | GLU227 |
| E | HOH604 |
| F | ALA249 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 504 |
| Chain | Residue |
| E | PRO270 |
| E | ASP272 |
| E | HOH602 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO E 505 |
| Chain | Residue |
| B | LEU172 |
| B | HIS173 |
| B | ASN209 |
| E | LEU172 |
| E | GLU205 |
| E | ASN209 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue DMS E 506 |
| Chain | Residue |
| E | TYR159 |
| E | GLU296 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue DMS E 507 |
| Chain | Residue |
| E | ARG9 |
| E | LEU31 |
| E | GLY32 |
| E | TYR33 |
| site_id | AG5 |
| Number of Residues | 1 |
| Details | binding site for residue CL E 508 |
| Chain | Residue |
| E | VAL94 |
| site_id | AG6 |
| Number of Residues | 9 |
| Details | binding site for residue UXP F 501 |
| Chain | Residue |
| F | HIS117 |
| F | GLY118 |
| F | THR182 |
| F | ASN183 |
| F | CYS219 |
| F | TYR239 |
| F | HIS281 |
| F | LEU284 |
| F | ASN285 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 502 |
| Chain | Residue |
| F | LEU229 |
| F | THR238 |
| F | ASP244 |
| F | ALA245 |
| site_id | AG8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 503 |
| Chain | Residue |
| F | PRO96 |
| F | GLU99 |
| F | HIS173 |
| H | HIS208 |
| H | ARG234 |
| site_id | AG9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 504 |
| Chain | Residue |
| F | PRO270 |
| F | LEU271 |
| F | ASP272 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue DMS F 505 |
| Chain | Residue |
| F | ARG158 |
| F | TYR159 |
| F | GLU296 |
| F | HOH620 |
| F | HOH638 |
| site_id | AH2 |
| Number of Residues | 1 |
| Details | binding site for residue CL F 506 |
| Chain | Residue |
| F | VAL94 |
| site_id | AH3 |
| Number of Residues | 10 |
| Details | binding site for residue UXP G 501 |
| Chain | Residue |
| G | HIS117 |
| G | GLY118 |
| G | THR182 |
| G | ASN183 |
| G | CYS219 |
| G | TYR239 |
| G | HIS281 |
| G | LEU284 |
| G | ASN285 |
| G | HOH629 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO G 502 |
| Chain | Residue |
| A | HIS208 |
| A | ARG234 |
| G | PRO96 |
| G | GLU99 |
| G | HIS173 |
| site_id | AH5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO G 503 |
| Chain | Residue |
| G | PRO270 |
| G | LEU271 |
| G | ASP272 |
| site_id | AH6 |
| Number of Residues | 4 |
| Details | binding site for residue DMS G 504 |
| Chain | Residue |
| F | HOH604 |
| G | TYR159 |
| G | GLU296 |
| G | GLY297 |
| site_id | AH7 |
| Number of Residues | 1 |
| Details | binding site for residue CL G 505 |
| Chain | Residue |
| G | VAL94 |
| site_id | AH8 |
| Number of Residues | 9 |
| Details | binding site for residue UXP H 501 |
| Chain | Residue |
| H | HIS117 |
| H | GLY118 |
| H | THR182 |
| H | ASN183 |
| H | CYS219 |
| H | TYR239 |
| H | HIS281 |
| H | LEU284 |
| H | ASN285 |
| site_id | AH9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO H 502 |
| Chain | Residue |
| F | HIS208 |
| F | ARG234 |
| H | PRO96 |
| H | GLU99 |
| H | HIS173 |
| site_id | AI1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO H 503 |
| Chain | Residue |
| B | PRO223 |
| H | ASP221 |
| H | LEU241 |
| H | LEU284 |
| H | HOH603 |
| site_id | AI2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 504 |
| Chain | Residue |
| H | PRO270 |
| H | ASP272 |
| H | HOH630 |
| site_id | AI3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS H 505 |
| Chain | Residue |
| H | ARG158 |
| H | TYR159 |
| H | GLU296 |
| H | HOH612 |
| site_id | AI4 |
| Number of Residues | 1 |
| Details | binding site for residue CL H 506 |
| Chain | Residue |
| H | VAL94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00046","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
