6X9C
Structure of proline utilization A with L-proline bound in the L-glutamate-gamma-semialdehyde dehydrogenase active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0003842 | molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity |
| A | 0004657 | molecular_function | proline dehydrogenase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006560 | biological_process | proline metabolic process |
| A | 0006561 | biological_process | proline biosynthetic process |
| A | 0006562 | biological_process | proline catabolic process |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0010133 | biological_process | proline catabolic process to glutamate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0003842 | molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity |
| B | 0004657 | molecular_function | proline dehydrogenase activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006560 | biological_process | proline metabolic process |
| B | 0006561 | biological_process | proline biosynthetic process |
| B | 0006562 | biological_process | proline catabolic process |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0010133 | biological_process | proline catabolic process to glutamate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue NAI A 1301 |
| Chain | Residue |
| A | ILE703 |
| A | ALA767 |
| A | PHE780 |
| A | GLY782 |
| A | SER783 |
| A | VAL786 |
| A | GLU810 |
| A | GLY812 |
| A | CYS844 |
| A | GLU940 |
| A | PHE942 |
| A | SER704 |
| A | MG1308 |
| A | HOH1420 |
| A | HOH1773 |
| A | HOH1999 |
| A | HOH2174 |
| B | ASP414 |
| B | HOH1882 |
| A | PRO705 |
| A | TRP706 |
| A | ASN707 |
| A | LYS730 |
| A | ALA732 |
| A | GLU733 |
| A | GLY766 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 1302 |
| Chain | Residue |
| A | GLY1079 |
| A | LEU1096 |
| A | HIS1097 |
| A | HOH1467 |
| A | HOH1729 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 1303 |
| Chain | Residue |
| A | ARG40 |
| A | ALA387 |
| A | HOH1507 |
| A | HOH1617 |
| A | HOH1853 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | binding site for residue FDA A 1304 |
| Chain | Residue |
| A | ASP306 |
| A | ALA307 |
| A | VAL338 |
| A | GLN340 |
| A | TYR342 |
| A | ARG367 |
| A | VAL369 |
| A | LYS370 |
| A | GLY371 |
| A | ALA372 |
| A | TYR373 |
| A | TRP374 |
| A | PHE392 |
| A | THR393 |
| A | ARG394 |
| A | LYS395 |
| A | THR398 |
| A | ALA421 |
| A | THR422 |
| A | HIS423 |
| A | ASN424 |
| A | GLN447 |
| A | CYS448 |
| A | TYR473 |
| A | GLU492 |
| A | ASN493 |
| A | SER497 |
| A | SER498 |
| A | PHE499 |
| A | HOH1897 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 1305 |
| Chain | Residue |
| A | ARG688 |
| A | PRO1039 |
| A | GLN1040 |
| A | HOH1510 |
| A | HOH1530 |
| A | HOH2102 |
| A | HOH2118 |
| B | SER94 |
| B | GLN96 |
| B | ARG170 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1306 |
| Chain | Residue |
| A | SER1194 |
| A | GLY1196 |
| A | ARG1200 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1307 |
| Chain | Residue |
| A | GLN853 |
| A | GLU854 |
| A | ASP855 |
| A | ARG952 |
| A | ARG953 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 1308 |
| Chain | Residue |
| A | NAI1301 |
| B | ASP414 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue PRO A 1309 |
| Chain | Residue |
| A | GLU674 |
| A | PHE708 |
| A | ARG843 |
| A | SER845 |
| A | GLY1002 |
| A | ALA1003 |
| A | PHE1010 |
| A | HOH1481 |
| A | HOH1551 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue PRO A 1310 |
| Chain | Residue |
| B | GLY1159 |
| A | ARG358 |
| A | ARG359 |
| B | ALA1156 |
| B | ALA1157 |
| site_id | AD2 |
| Number of Residues | 39 |
| Details | binding site for residue NAI B 1301 |
| Chain | Residue |
| A | HOH1529 |
| A | HOH1596 |
| B | ILE703 |
| B | SER704 |
| B | PRO705 |
| B | TRP706 |
| B | ASN707 |
| B | ILE712 |
| B | LYS730 |
| B | ALA732 |
| B | GLU733 |
| B | ASP762 |
| B | GLY763 |
| B | GLY766 |
| B | ALA767 |
| B | PHE780 |
| B | THR781 |
| B | GLY782 |
| B | SER783 |
| B | VAL786 |
| B | GLU810 |
| B | THR811 |
| B | GLY812 |
| B | CYS844 |
| B | GLU940 |
| B | PHE942 |
| B | PHE1010 |
| B | MG1306 |
| B | HOH1402 |
| B | HOH1446 |
| B | HOH1454 |
| B | HOH1586 |
| B | HOH1703 |
| B | HOH1773 |
| B | HOH1798 |
| B | HOH1951 |
| B | HOH2066 |
| B | HOH2094 |
| B | HOH2116 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue PGE B 1302 |
| Chain | Residue |
| B | GLY1079 |
| B | LEU1096 |
| B | HIS1097 |
| B | HOH1432 |
| B | HOH1548 |
| site_id | AD4 |
| Number of Residues | 30 |
| Details | binding site for residue FDA B 1303 |
| Chain | Residue |
| B | ASP306 |
| B | ALA307 |
| B | VAL338 |
| B | GLN340 |
| B | TYR342 |
| B | ARG367 |
| B | VAL369 |
| B | LYS370 |
| B | GLY371 |
| B | ALA372 |
| B | TYR373 |
| B | TRP374 |
| B | PHE392 |
| B | THR393 |
| B | ARG394 |
| B | LYS395 |
| B | THR398 |
| B | ALA421 |
| B | THR422 |
| B | HIS423 |
| B | ASN424 |
| B | GLN447 |
| B | CYS448 |
| B | TYR473 |
| B | GLU492 |
| B | ASN493 |
| B | SER498 |
| B | PHE499 |
| B | HOH1596 |
| B | HOH1749 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 1304 |
| Chain | Residue |
| A | SER94 |
| A | ARG170 |
| B | ARG688 |
| B | PRO1039 |
| B | GLN1040 |
| B | HOH1418 |
| B | HOH1549 |
| B | HOH1564 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 1306 |
| Chain | Residue |
| A | HOH1529 |
| A | HOH1596 |
| B | NAI1301 |
| B | HOH1586 |
| B | HOH2066 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue PRO B 1307 |
| Chain | Residue |
| B | GLU674 |
| B | PHE708 |
| B | ARG843 |
| B | CYS844 |
| B | SER845 |
| B | GLY1002 |
| B | ALA1003 |
| B | PHE1010 |
| B | HOH1481 |
| B | HOH1505 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FdSAGQRCSALR |
| Chain | Residue | Details |
| A | PHE837-ARG848 |
