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6X83

Crystal Structure of TNFalpha with fragment compound 6

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
D0005164molecular_functiontumor necrosis factor receptor binding
D0006955biological_processimmune response
D0016020cellular_componentmembrane
E0005164molecular_functiontumor necrosis factor receptor binding
E0006955biological_processimmune response
E0016020cellular_componentmembrane
F0005164molecular_functiontumor necrosis factor receptor binding
F0006955biological_processimmune response
F0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue UTS A 201
ChainResidue
ALEU57
AGLY121
AGLY122
BLEU57
BSER60
BTYR119
BGLY121
BTYR151
CUTS201

site_idAC2
Number of Residues8
Detailsbinding site for residue UTS C 201
ChainResidue
ATYR59
ASER60
ALEU120
AUTS201
BTYR119
CLEU57
CLEU120
CGLY121

site_idAC3
Number of Residues10
Detailsbinding site for residue UTS E 901
ChainResidue
DLEU57
DGLY121
DGLY122
ELEU57
ESER60
ETYR119
ELEU120
EGLY121
ETYR151
FUTS201

site_idAC4
Number of Residues10
Detailsbinding site for residue UTS F 201
ChainResidue
DTYR59
DSER60
DTYR119
DLEU120
ETYR119
EUTS901
FLEU57
FTYR119
FLEU120
FGLY121

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

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PDB entries from 2025-12-17

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