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6X82

Crystal Structure of TNFalpha with isoquinoline compound 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
D0005164molecular_functiontumor necrosis factor receptor binding
D0006955biological_processimmune response
D0016020cellular_componentmembrane
E0005164molecular_functiontumor necrosis factor receptor binding
E0006955biological_processimmune response
E0016020cellular_componentmembrane
F0005164molecular_functiontumor necrosis factor receptor binding
F0006955biological_processimmune response
F0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue UTM A 901
ChainResidue
ALEU57
BTYR59
BSER60
BTYR119
BLEU120
BGLY121
BTYR151
BILE155
CTYR119
CGLY121
CGLY122
ATYR59
ASER60
ALEU120
AGLY121
ATYR151
AALA156
ALEU157
BLEU57

site_idAC2
Number of Residues17
Detailsbinding site for residue UTM D 201
ChainResidue
DTYR59
DSER60
DLEU120
DGLY121
DTYR151
DALA156
DLEU157
ELEU57
ETYR59
ESER60
ETYR119
ELEU120
EGLY121
ETYR151
FTYR119
FGLY121
FGLY122

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

246704

PDB entries from 2025-12-24

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