6X7V

Crystal Structure of the Human Nudix Hydrolase Nudt16

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006402	biological_process	mRNA catabolic process
A	0008235	molecular_function	metalloexopeptidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016077	biological_process	sno(s)RNA catabolic process
A	0016787	molecular_function	hydrolase activity
A	0017110	molecular_function	nucleoside diphosphate phosphatase activity
A	0030145	molecular_function	manganese ion binding
A	0030515	molecular_function	snoRNA binding
A	0031404	molecular_function	chloride ion binding
A	0035863	biological_process	dITP catabolic process
A	0035870	molecular_function	dITP diphosphatase activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0050897	molecular_function	cobalt ion binding
A	0090068	biological_process	positive regulation of cell cycle process
A	0097383	molecular_function	dIDP phosphatase activity
A	0110153	molecular_function	RNA NAD-cap (NMN-forming) hydrolase activity
A	0110155	biological_process	NAD-cap decapping
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
A	1990003	molecular_function	IDP phosphatase activity
A	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
A	2000233	biological_process	negative regulation of rRNA processing
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0006402	biological_process	mRNA catabolic process
B	0008235	molecular_function	metalloexopeptidase activity
B	0009117	biological_process	nucleotide metabolic process
B	0016077	biological_process	sno(s)RNA catabolic process
B	0016787	molecular_function	hydrolase activity
B	0017110	molecular_function	nucleoside diphosphate phosphatase activity
B	0030145	molecular_function	manganese ion binding
B	0030515	molecular_function	snoRNA binding
B	0031404	molecular_function	chloride ion binding
B	0035863	biological_process	dITP catabolic process
B	0035870	molecular_function	dITP diphosphatase activity
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0050897	molecular_function	cobalt ion binding
B	0090068	biological_process	positive regulation of cell cycle process
B	0097383	molecular_function	dIDP phosphatase activity
B	0110153	molecular_function	RNA NAD-cap (NMN-forming) hydrolase activity
B	0110155	biological_process	NAD-cap decapping
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	1990003	molecular_function	IDP phosphatase activity
B	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
B	2000233	biological_process	negative regulation of rRNA processing
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006402	biological_process	mRNA catabolic process
C	0008235	molecular_function	metalloexopeptidase activity
C	0009117	biological_process	nucleotide metabolic process
C	0016077	biological_process	sno(s)RNA catabolic process
C	0016787	molecular_function	hydrolase activity
C	0017110	molecular_function	nucleoside diphosphate phosphatase activity
C	0030145	molecular_function	manganese ion binding
C	0030515	molecular_function	snoRNA binding
C	0031404	molecular_function	chloride ion binding
C	0035863	biological_process	dITP catabolic process
C	0035870	molecular_function	dITP diphosphatase activity
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0050897	molecular_function	cobalt ion binding
C	0090068	biological_process	positive regulation of cell cycle process
C	0097383	molecular_function	dIDP phosphatase activity
C	0110153	molecular_function	RNA NAD-cap (NMN-forming) hydrolase activity
C	0110155	biological_process	NAD-cap decapping
C	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C	1990003	molecular_function	IDP phosphatase activity
C	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
C	2000233	biological_process	negative regulation of rRNA processing
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0006402	biological_process	mRNA catabolic process
D	0008235	molecular_function	metalloexopeptidase activity
D	0009117	biological_process	nucleotide metabolic process
D	0016077	biological_process	sno(s)RNA catabolic process
D	0016787	molecular_function	hydrolase activity
D	0017110	molecular_function	nucleoside diphosphate phosphatase activity
D	0030145	molecular_function	manganese ion binding
D	0030515	molecular_function	snoRNA binding
D	0031404	molecular_function	chloride ion binding
D	0035863	biological_process	dITP catabolic process
D	0035870	molecular_function	dITP diphosphatase activity
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding
D	0050897	molecular_function	cobalt ion binding
D	0090068	biological_process	positive regulation of cell cycle process
D	0097383	molecular_function	dIDP phosphatase activity
D	0110153	molecular_function	RNA NAD-cap (NMN-forming) hydrolase activity
D	0110155	biological_process	NAD-cap decapping
D	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
D	1990003	molecular_function	IDP phosphatase activity
D	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
D	2000233	biological_process	negative regulation of rRNA processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 201

Chain	Residue
A	HIS99
A	GLU173
C	HIS99
C	GLU173

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL D 201

Chain	Residue
A	MET34
D	ARG149

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26121039","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32432673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26121039","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6X7U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q6TEC1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32432673","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6X7V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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