6X7Q

Chloramphenicol acetyltransferase type III in complex with chloramphenicol and acetyl-oxa(dethia)-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008811	molecular_function	chloramphenicol O-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0008811	molecular_function	chloramphenicol O-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0008811	molecular_function	chloramphenicol O-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic

Functional Information from PROSITE/UniProt

site_id	PS00100
Number of Residues	11
Details	CAT Chloramphenicol acetyltransferase active site. QVHHAvcDGFH

Chain	Residue	Details
A	GLN186-HIS196

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 934

Chain	Residue	Details
A	ARG13	electrostatic stabiliser
A	THR168	activator, transition state stabiliser
A	HIS189	proton shuttle (general acid/base)
A	ASP193	electrostatic stabiliser, modifies pKa

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 934

Chain	Residue	Details
B	ARG13	electrostatic stabiliser
B	THR168	activator, transition state stabiliser
B	HIS189	proton shuttle (general acid/base)
B	ASP193	electrostatic stabiliser, modifies pKa

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 934

Chain	Residue	Details
C	ARG13	electrostatic stabiliser
C	THR168	activator, transition state stabiliser
C	HIS189	proton shuttle (general acid/base)
C	ASP193	electrostatic stabiliser, modifies pKa

---