Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X5Z

Bovine Cardiac Myosin in Complex with Chicken Skeletal Actin and Human Cardiac Tropomyosin in the Rigor State

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001725	cellular_component	stress fiber
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0048741	biological_process	skeletal muscle fiber development
B	0000166	molecular_function	nucleotide binding
B	0001725	cellular_component	stress fiber
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0048741	biological_process	skeletal muscle fiber development
C	0000166	molecular_function	nucleotide binding
C	0001725	cellular_component	stress fiber
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0048741	biological_process	skeletal muscle fiber development
D	0003774	molecular_function	cytoskeletal motor activity
D	0005524	molecular_function	ATP binding
D	0016459	cellular_component	myosin complex
D	0051015	molecular_function	actin filament binding
G	0003774	molecular_function	cytoskeletal motor activity
G	0005524	molecular_function	ATP binding
G	0016459	cellular_component	myosin complex
G	0051015	molecular_function	actin filament binding
J	0003774	molecular_function	cytoskeletal motor activity
J	0005524	molecular_function	ATP binding
J	0016459	cellular_component	myosin complex
J	0051015	molecular_function	actin filament binding
O	0001725	cellular_component	stress fiber
O	0003065	biological_process	positive regulation of heart rate by epinephrine
O	0003779	molecular_function	actin binding
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005862	cellular_component	muscle thin filament tropomyosin
O	0005884	cellular_component	actin filament
O	0006937	biological_process	regulation of muscle contraction
O	0007010	biological_process	cytoskeleton organization
O	0007015	biological_process	actin filament organization
O	0008016	biological_process	regulation of heart contraction
O	0008092	molecular_function	cytoskeletal protein binding
O	0008307	molecular_function	structural constituent of muscle
O	0008360	biological_process	regulation of cell shape
O	0015629	cellular_component	actin cytoskeleton
O	0030017	cellular_component	sarcomere
O	0030049	biological_process	muscle filament sliding
O	0030336	biological_process	negative regulation of cell migration
O	0031529	biological_process	ruffle organization
O	0032059	cellular_component	bleb
O	0032587	cellular_component	ruffle membrane
O	0034614	biological_process	cellular response to reactive oxygen species
O	0042060	biological_process	wound healing
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0045214	biological_process	sarcomere organization
O	0045785	biological_process	positive regulation of cell adhesion
O	0046982	molecular_function	protein heterodimerization activity
O	0051015	molecular_function	actin filament binding
O	0051496	biological_process	positive regulation of stress fiber assembly
O	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
O	0060048	biological_process	cardiac muscle contraction
O	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
O	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
P	0001725	cellular_component	stress fiber
P	0003065	biological_process	positive regulation of heart rate by epinephrine
P	0003779	molecular_function	actin binding
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005862	cellular_component	muscle thin filament tropomyosin
P	0005884	cellular_component	actin filament
P	0006937	biological_process	regulation of muscle contraction
P	0007010	biological_process	cytoskeleton organization
P	0007015	biological_process	actin filament organization
P	0008016	biological_process	regulation of heart contraction
P	0008092	molecular_function	cytoskeletal protein binding
P	0008307	molecular_function	structural constituent of muscle
P	0008360	biological_process	regulation of cell shape
P	0015629	cellular_component	actin cytoskeleton
P	0030017	cellular_component	sarcomere
P	0030049	biological_process	muscle filament sliding
P	0030336	biological_process	negative regulation of cell migration
P	0031529	biological_process	ruffle organization
P	0032059	cellular_component	bleb
P	0032587	cellular_component	ruffle membrane
P	0034614	biological_process	cellular response to reactive oxygen species
P	0042060	biological_process	wound healing
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0045214	biological_process	sarcomere organization
P	0045785	biological_process	positive regulation of cell adhesion
P	0046982	molecular_function	protein heterodimerization activity
P	0051015	molecular_function	actin filament binding
P	0051496	biological_process	positive regulation of stress fiber assembly
P	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
P	0060048	biological_process	cardiac muscle contraction
P	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
P	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue ADP B 401

Chain	Residue
B	ASP11
B	TYR306
B	MG402
B	GLY13
B	GLY15
B	LEU16
B	LYS18
B	GLY156
B	ASP157
B	GLU214
B	THR303

site_id	AC2
Number of Residues	4
Details	binding site for residue MG B 402

Chain	Residue
B	GLY13
B	GLY15
B	LEU16
B	ADP401

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	GLY13
A	GLY15
A	LEU16
A	ADP401

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 402

Chain	Residue
C	GLY13
C	GLY15
C	LEU16
C	ADP401

site_id	AC5
Number of Residues	17
Details	binding site for residue ADP A 401

Chain	Residue
A	ASP11
A	GLY13
A	SER14
A	GLY15
A	LEU16
A	LYS18
A	SER155
A	GLY156
A	GLY158
A	VAL159
A	ALA181
A	GLY182
A	ARG183
A	GLU214
A	THR303
A	TYR306
A	MG402

site_id	AC6
Number of Residues	17
Details	binding site for residue ADP C 401

Chain	Residue
C	ASP11
C	GLY13
C	SER14
C	GLY15
C	LEU16
C	LYS18
C	SER155
C	GLY156
C	GLY158
C	VAL159
C	ALA181
C	GLY182
C	ARG183
C	GLU214
C	THR303
C	TYR306
C	MG402

Functional Information from PROSITE/UniProt

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
O	LEU232-GLU240

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
B	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
B	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
B	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
G	GLY178
D	GLY178
J	GLY178

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000255

Chain	Residue	Details
G	LYS129
D	LYS129
J	LYS129

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P02563

Chain	Residue	Details
G	THR378
D	THR378
J	THR378
A	MET47
C	MET44
C	MET47

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P58771

Chain	Residue	Details
O	SER186
O	SER206
O	SER252
O	SER271
P	SER186
P	SER206
P	SER252
P	SER271

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P04692

Chain	Residue	Details
O	TYR261
P	TYR261
C	LYS84

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by DAPK1 => ECO:0000269\|PubMed:17895359

Chain	Residue	Details
O	SER283
P	SER283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)