6X5K
Crystal structure of CODH/ACS with carbon monoxide bound to the A-cluster
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0015977 | biological_process | carbon fixation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0043885 | molecular_function | carbon-monoxide dehydrogenase (ferredoxin) activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050418 | molecular_function | hydroxylamine reductase activity |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0015977 | biological_process | carbon fixation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0043885 | molecular_function | carbon-monoxide dehydrogenase (ferredoxin) activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050418 | molecular_function | hydroxylamine reductase activity |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0006091 | biological_process | generation of precursor metabolites and energy |
| C | 0015977 | biological_process | carbon fixation |
| C | 0016151 | molecular_function | nickel cation binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| C | 0042542 | biological_process | response to hydrogen peroxide |
| C | 0043885 | molecular_function | carbon-monoxide dehydrogenase (ferredoxin) activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0050418 | molecular_function | hydroxylamine reductase activity |
| C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0006091 | biological_process | generation of precursor metabolites and energy |
| D | 0015977 | biological_process | carbon fixation |
| D | 0016151 | molecular_function | nickel cation binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| D | 0042542 | biological_process | response to hydrogen peroxide |
| D | 0043885 | molecular_function | carbon-monoxide dehydrogenase (ferredoxin) activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050418 | molecular_function | hydroxylamine reductase activity |
| D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| M | 0003824 | molecular_function | catalytic activity |
| M | 0006084 | biological_process | acetyl-CoA metabolic process |
| M | 0015977 | biological_process | carbon fixation |
| M | 0016491 | molecular_function | oxidoreductase activity |
| M | 0016740 | molecular_function | transferase activity |
| M | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| M | 0043884 | molecular_function | CO-methylating acetyl-CoA synthase activity |
| M | 0046872 | molecular_function | metal ion binding |
| M | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| N | 0003824 | molecular_function | catalytic activity |
| N | 0006084 | biological_process | acetyl-CoA metabolic process |
| N | 0015977 | biological_process | carbon fixation |
| N | 0016491 | molecular_function | oxidoreductase activity |
| N | 0016740 | molecular_function | transferase activity |
| N | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| N | 0043884 | molecular_function | CO-methylating acetyl-CoA synthase activity |
| N | 0046872 | molecular_function | metal ion binding |
| N | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| O | 0003824 | molecular_function | catalytic activity |
| O | 0006084 | biological_process | acetyl-CoA metabolic process |
| O | 0015977 | biological_process | carbon fixation |
| O | 0016491 | molecular_function | oxidoreductase activity |
| O | 0016740 | molecular_function | transferase activity |
| O | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| O | 0043884 | molecular_function | CO-methylating acetyl-CoA synthase activity |
| O | 0046872 | molecular_function | metal ion binding |
| O | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| P | 0003824 | molecular_function | catalytic activity |
| P | 0006084 | biological_process | acetyl-CoA metabolic process |
| P | 0015977 | biological_process | carbon fixation |
| P | 0016491 | molecular_function | oxidoreductase activity |
| P | 0016740 | molecular_function | transferase activity |
| P | 0018492 | molecular_function | carbon-monoxide dehydrogenase (acceptor) activity |
| P | 0043884 | molecular_function | CO-methylating acetyl-CoA synthase activity |
| P | 0046872 | molecular_function | metal ion binding |
| P | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 A 701 |
| Chain | Residue |
| A | CYS59 |
| A | GLY62 |
| A | CYS67 |
| A | ARG69 |
| B | CYS59 |
| B | GLY62 |
| B | CYS67 |
| B | ARG69 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 A 702 |
| Chain | Residue |
| A | CYS71 |
| A | CYS76 |
| A | CYS90 |
| A | ARG100 |
| A | MET221 |
| A | CYS68 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue XCC A 703 |
| Chain | Residue |
| A | HIS283 |
| A | CYS317 |
| A | CYS355 |
| A | GLY469 |
| A | CYS470 |
| A | CYS500 |
| A | CYS550 |
| A | SER585 |
| A | LYS587 |
| A | HOH882 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue PGE A 704 |
| Chain | Residue |
| A | LYS60 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SF4 B 701 |
| Chain | Residue |
| B | CYS68 |
| B | CYS71 |
| B | CYS76 |
| B | CYS90 |
| B | ARG100 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue XCC B 702 |
| Chain | Residue |
| B | HIS283 |
| B | CYS317 |
| B | CYS355 |
| B | GLY469 |
| B | CYS470 |
| B | CYS500 |
| B | CYS550 |
| B | SER585 |
| B | LYS587 |
| B | HOH876 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 C 701 |
| Chain | Residue |
| C | CYS59 |
| C | GLY62 |
| C | CYS67 |
| C | ARG69 |
| D | CYS59 |
| D | GLY62 |
| D | CYS67 |
| D | ARG69 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 C 702 |
| Chain | Residue |
| C | CYS68 |
| C | CYS71 |
| C | CYS76 |
| C | CYS90 |
| C | ARG100 |
| C | MET221 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue XCC C 703 |
| Chain | Residue |
| C | HIS283 |
| C | CYS317 |
| C | PHE334 |
| C | CYS355 |
| C | GLY469 |
| C | CYS470 |
| C | CYS500 |
| C | CYS550 |
| C | SER585 |
| C | LYS587 |
| C | HOH844 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PG5 C 704 |
| Chain | Residue |
| C | LYS60 |
| C | ILE61 |
| D | LYS60 |
| P | GLU716 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 D 701 |
| Chain | Residue |
| D | CYS68 |
| D | CYS71 |
| D | GLY74 |
| D | CYS76 |
| D | CYS90 |
| D | ARG100 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue XCC D 702 |
| Chain | Residue |
| D | HIS283 |
| D | CYS316 |
| D | CYS317 |
| D | PHE334 |
| D | CYS355 |
| D | GLY469 |
| D | CYS470 |
| D | CYS500 |
| D | CYS550 |
| D | SER585 |
| D | LYS587 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 M 801 |
| Chain | Residue |
| M | ILE146 |
| M | CYS506 |
| M | CYS509 |
| M | CYS518 |
| M | GLY526 |
| M | LEU527 |
| M | CYS528 |
| M | VAL531 |
| M | CYS597 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue NI M 802 |
| Chain | Residue |
| M | CMO804 |
| M | CYS509 |
| M | CYS595 |
| M | CYS597 |
| M | NI803 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue NI M 803 |
| Chain | Residue |
| M | CYS595 |
| M | GLY596 |
| M | CYS597 |
| M | NI802 |
| M | CMO804 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue CMO M 804 |
| Chain | Residue |
| M | GLY145 |
| M | CYS509 |
| M | CYS595 |
| M | CYS597 |
| M | NI802 |
| M | NI803 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 N 801 |
| Chain | Residue |
| N | ILE146 |
| N | CYS506 |
| N | CYS509 |
| N | CYS518 |
| N | GLY526 |
| N | LEU527 |
| N | CYS528 |
| N | CYS597 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue NI N 802 |
| Chain | Residue |
| N | CYS509 |
| N | CYS595 |
| N | CYS597 |
| N | NI803 |
| N | CMO804 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue NI N 803 |
| Chain | Residue |
| N | CYS595 |
| N | GLY596 |
| N | CYS597 |
| N | PHE598 |
| N | NI802 |
| N | CMO804 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue CMO N 804 |
| Chain | Residue |
| N | CYS509 |
| N | CYS595 |
| N | CYS597 |
| N | NI802 |
| N | NI803 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue MG N 805 |
| Chain | Residue |
| N | PHE328 |
| N | GLU331 |
| N | ASN412 |
| N | GLY414 |
| N | LEU417 |
| N | HOH962 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue SF4 O 900 |
| Chain | Residue |
| O | ILE146 |
| O | CYS506 |
| O | CYS509 |
| O | CYS518 |
| O | LEU527 |
| O | CYS528 |
| O | CYS597 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue NI O 901 |
| Chain | Residue |
| O | CYS509 |
| O | CYS595 |
| O | CYS597 |
| O | NI902 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue NI O 902 |
| Chain | Residue |
| O | CYS595 |
| O | GLY596 |
| O | CYS597 |
| O | NI901 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 P 801 |
| Chain | Residue |
| P | CYS506 |
| P | CYS509 |
| P | CYS518 |
| P | GLY526 |
| P | LEU527 |
| P | CYS528 |
| P | VAL531 |
| P | CYS597 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue NI P 802 |
| Chain | Residue |
| P | CYS509 |
| P | CYS595 |
| P | CYS597 |
| P | NI803 |
| P | CMO804 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue NI P 803 |
| Chain | Residue |
| P | CYS595 |
| P | GLY596 |
| P | CYS597 |
| P | NI802 |
| P | CMO804 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue CMO P 804 |
| Chain | Residue |
| P | CYS509 |
| P | CYS595 |
| P | CYS597 |
| P | NI802 |
| P | NI803 |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 18 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGILVDIYGRKmqadfeG |
| Chain | Residue | Details |
| M | LEU384-GLY401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: |
| Chain | Residue | Details |
| N | GLY596 | |
| N | CYS597 | |
| O | CYS506 | |
| O | CYS509 | |
| O | CYS518 | |
| O | CYS528 | |
| O | CYS595 | |
| O | GLY596 | |
| O | CYS597 | |
| P | CYS506 | |
| P | CYS509 | |
| P | CYS518 | |
| P | CYS528 | |
| P | CYS595 | |
| P | GLY596 | |
| P | CYS597 | |
| C | CYS76 | |
| C | CYS90 | |
| C | HIS283 | |
| C | CYS317 | |
| C | CYS355 | |
| C | CYS470 | |
| C | CYS500 | |
| C | CYS550 | |
| D | CYS59 | |
| D | CYS67 | |
| D | CYS68 | |
| D | CYS71 | |
| D | CYS76 | |
| D | CYS90 | |
| D | HIS283 | |
| D | CYS317 | |
| D | CYS355 | |
| D | CYS470 | |
| D | CYS500 | |
| D | CYS550 | |
| M | CYS595 | |
| M | GLY596 | |
| M | CYS597 | |
| N | CYS506 | |
| N | CYS509 | |
| N | CYS518 | |
| N | CYS528 | |
| N | CYS595 | |
| M | CYS506 | |
| M | CYS509 | |
| M | CYS518 | |
| M | CYS528 |
