6X3J

Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F0224 (46)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0046677	biological_process	response to antibiotic
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0046677	biological_process	response to antibiotic
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue O7V A 401

Chain	Residue
A	TYR57
C	PHE200
C	LYS212
C	LEU215
D	TYR42
D	SXA302
A	TYR59
A	VAL61
A	GLY84
A	HIS97
A	LEU98
A	MET107
A	PRO108
A	LEU113

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 A 402

Chain	Residue
A	GLY204
A	ASP205
A	ILE206
B	HOH512
C	LYS111

---

site_id	AC3
Number of Residues	14
Details	binding site for residue SXA A 403

Chain	Residue
A	GLY75
A	PRO76
A	TRP126
A	ILE127
A	ARG129
A	ALA146
A	ALA147
B	TYR57
B	ALA85
B	HIS87
B	LYS116
B	MET134
B	O7V402
B	HOH515

---

site_id	AC4
Number of Residues	12
Details	binding site for residue O7V B 401

Chain	Residue
B	TYR42
B	ASP44
B	SXA405
B	HOH524
D	TYR59
D	GLY84
D	ASN86
D	HIS87
D	HIS97
D	ARG100
D	PRO108
D	LEU113

---

site_id	AC5
Number of Residues	14
Details	binding site for residue O7V B 402

Chain	Residue
A	TYR42
A	SXA403
B	TYR59
B	GLU60
B	VAL61
B	GLY84
B	ASN86
B	HIS87
B	HIS97
B	PRO108
B	LEU113
B	HOH519
B	HOH522
E	ARG211

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL B 403

Chain	Residue
A	HOH526
A	HOH535
B	HOH528
B	HOH542

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL B 404

Chain	Residue
B	ASN83
B	LEU115
B	GLY117

---

site_id	AC8
Number of Residues	10
Details	binding site for residue SXA B 405

Chain	Residue
B	TRP126
B	ILE127
B	GLY128
B	ARG129
B	ALA146
B	ALA147
B	O7V401
D	ALA85
D	ASN86
D	HIS87

---

site_id	AC9
Number of Residues	16
Details	binding site for residue O7V C 401

Chain	Residue
A	PHE200
A	MET208
A	LYS212
C	TYR57
C	TYR59
C	VAL61
C	GLY84
C	ASN86
C	HIS87
C	HIS97
C	ARG100
C	MET107
C	PRO108
E	TYR42
E	ASP44
E	SXA407

---

site_id	AD1
Number of Residues	2
Details	binding site for residue CL C 403

Chain	Residue
C	ASP10
C	ASN13

---

site_id	AD2
Number of Residues	7
Details	binding site for residue MG C 404

Chain	Residue
F	HOH514
F	HOH522
C	ASN164
C	PRO165
E	ASN164
E	HOH521
F	ASN164

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MG D 301

Chain	Residue
A	ASN164
A	HOH520
B	ASN164
B	HOH509
D	ASN164
D	HOH424

---

site_id	AD4
Number of Residues	13
Details	binding site for residue SXA D 302

Chain	Residue
A	ALA85
A	ASN86
A	HIS87
A	O7V401
D	GLY75
D	TRP126
D	ILE127
D	GLY128
D	ARG129
D	ALA146
D	ALA147
D	HOH401
D	HOH415

---

site_id	AD5
Number of Residues	13
Details	binding site for residue O7V E 401

Chain	Residue
E	TYR59
E	VAL61
E	GLY84
E	ASN86
E	HIS87
E	HIS97
E	ARG100
E	MET107
E	PRO108
E	LEU113
F	TYR42
F	ASP44
F	SXA405

---

site_id	AD6
Number of Residues	1
Details	binding site for residue CL E 402

Chain	Residue
F	HOH534

---

site_id	AD7
Number of Residues	3
Details	binding site for residue CL E 403

Chain	Residue
E	PHE173
E	SER174
F	MET208

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CL E 404

Chain	Residue
E	LEU15
E	PRO16
E	ILE17
E	ASN20
E	LEU23

---

site_id	AD9
Number of Residues	5
Details	binding site for residue CL E 405

Chain	Residue
C	ASN164
E	ALA147
E	GLU148
E	ALA149
E	GLY163

---

site_id	AE1
Number of Residues	5
Details	binding site for residue PO4 E 406

Chain	Residue
B	ASN13
B	LEU15
E	GLU12
E	ASN13
E	ILE14

---

site_id	AE2
Number of Residues	13
Details	binding site for residue SXA E 407

Chain	Residue
C	TYR57
C	ALA85
C	HIS87
C	O7V401
C	HOH507
E	TRP126
E	ILE127
E	GLY128
E	ARG129
E	ALA147
E	ILE160
E	HOH501
E	HOH518

---

site_id	AE3
Number of Residues	13
Details	binding site for residue O7V F 401

Chain	Residue
C	TYR42
C	ASP44
D	MET208
F	TYR59
F	GLU60
F	GLY84
F	ASN86
F	HIS87
F	HIS97
F	MET107
F	PRO108
F	LEU113
F	SXA406

---

site_id	AE4
Number of Residues	1
Details	binding site for residue CL F 402

Chain	Residue
F	HOH523

---

site_id	AE5
Number of Residues	6
Details	binding site for residue CL F 403

Chain	Residue
C	ILE202
F	ARG88
F	MET89
F	ASP90
F	GLY91
F	SER92

---

site_id	AE6
Number of Residues	4
Details	binding site for residue CL F 404

Chain	Residue
F	TRP181
F	GLN185
F	TRP186
F	TRP187

---

site_id	AE7
Number of Residues	14
Details	binding site for residue SXA F 405

Chain	Residue
E	ALA85
E	ASN86
E	HIS87
E	LYS116
E	O7V401
E	HOH504
F	GLY75
F	TRP126
F	ILE127
F	GLY128
F	ARG129
F	ALA146
F	ALA147
F	HOH501

---

site_id	AE8
Number of Residues	12
Details	binding site for residue SXA F 406

Chain	Residue
C	TRP126
C	GLY128
C	ARG129
C	ALA147
C	ILE160
C	ARG170
F	ALA85
F	HIS87
F	LYS116
F	O7V401
F	HOH505
F	HOH509

---

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGrdVtImpgVkIGdgAiIAaeAvVtknV

Chain	Residue	Details
A	ILE127-VAL155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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