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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6X2F

Mfd-bound E.coli RNA polymerase elongation complex - L2 state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000716biological_processtranscription-coupled nucleotide-excision repair, DNA damage recognition
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006283biological_processtranscription-coupled nucleotide-excision repair
A0006294biological_processnucleotide-excision repair, preincision complex assembly
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0015616molecular_functionDNA translocase activity
A0016787molecular_functionhydrolase activity
A0043175molecular_functionRNA polymerase core enzyme binding
G0000428cellular_componentDNA-directed RNA polymerase complex
G0003677molecular_functionDNA binding
G0003899molecular_functionDNA-directed RNA polymerase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006351biological_processDNA-templated transcription
G0006352biological_processDNA-templated transcription initiation
G0006879biological_processintracellular iron ion homeostasis
G0009408biological_processresponse to heat
G0016020cellular_componentmembrane
G0016740molecular_functiontransferase activity
G0016779molecular_functionnucleotidyltransferase activity
G0031564biological_processtranscription antitermination
G0032784biological_processregulation of DNA-templated transcription elongation
G0034062molecular_function5'-3' RNA polymerase activity
G0036460biological_processcellular response to cell envelope stress
G0042128biological_processnitrate assimilation
G0044780biological_processbacterial-type flagellum assembly
G0046983molecular_functionprotein dimerization activity
G0048870biological_processcell motility
G0071973biological_processbacterial-type flagellum-dependent cell motility
G0090605biological_processsubmerged biofilm formation
G2000142biological_processregulation of DNA-templated transcription initiation
H0000428cellular_componentDNA-directed RNA polymerase complex
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed RNA polymerase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006351biological_processDNA-templated transcription
H0006352biological_processDNA-templated transcription initiation
H0006879biological_processintracellular iron ion homeostasis
H0009408biological_processresponse to heat
H0016020cellular_componentmembrane
H0016740molecular_functiontransferase activity
H0016779molecular_functionnucleotidyltransferase activity
H0031564biological_processtranscription antitermination
H0032784biological_processregulation of DNA-templated transcription elongation
H0034062molecular_function5'-3' RNA polymerase activity
H0036460biological_processcellular response to cell envelope stress
H0042128biological_processnitrate assimilation
H0044780biological_processbacterial-type flagellum assembly
H0046983molecular_functionprotein dimerization activity
H0048870biological_processcell motility
H0071973biological_processbacterial-type flagellum-dependent cell motility
H0090605biological_processsubmerged biofilm formation
H2000142biological_processregulation of DNA-templated transcription initiation
I0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
I0000428cellular_componentDNA-directed RNA polymerase complex
I0003677molecular_functionDNA binding
I0003899molecular_functionDNA-directed RNA polymerase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006351biological_processDNA-templated transcription
I0006352biological_processDNA-templated transcription initiation
I0006354biological_processDNA-templated transcription elongation
I0006879biological_processintracellular iron ion homeostasis
I0009408biological_processresponse to heat
I0016020cellular_componentmembrane
I0016740molecular_functiontransferase activity
I0016779molecular_functionnucleotidyltransferase activity
I0031564biological_processtranscription antitermination
I0032549molecular_functionribonucleoside binding
I0032784biological_processregulation of DNA-templated transcription elongation
I0034062molecular_function5'-3' RNA polymerase activity
I0036460biological_processcellular response to cell envelope stress
I0042128biological_processnitrate assimilation
I0044780biological_processbacterial-type flagellum assembly
I0046677biological_processresponse to antibiotic
I0048870biological_processcell motility
I0071973biological_processbacterial-type flagellum-dependent cell motility
I0090605biological_processsubmerged biofilm formation
I2000142biological_processregulation of DNA-templated transcription initiation
J0000287molecular_functionmagnesium ion binding
J0000428cellular_componentDNA-directed RNA polymerase complex
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed RNA polymerase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006351biological_processDNA-templated transcription
J0006352biological_processDNA-templated transcription initiation
J0006879biological_processintracellular iron ion homeostasis
J0008270molecular_functionzinc ion binding
J0009408biological_processresponse to heat
J0016020cellular_componentmembrane
J0016740molecular_functiontransferase activity
J0016779molecular_functionnucleotidyltransferase activity
J0031564biological_processtranscription antitermination
J0032784biological_processregulation of DNA-templated transcription elongation
J0034062molecular_function5'-3' RNA polymerase activity
J0036460biological_processcellular response to cell envelope stress
J0042128biological_processnitrate assimilation
J0044780biological_processbacterial-type flagellum assembly
J0046677biological_processresponse to antibiotic
J0046872molecular_functionmetal ion binding
J0048870biological_processcell motility
J0071973biological_processbacterial-type flagellum-dependent cell motility
J0090605biological_processsubmerged biofilm formation
J2000142biological_processregulation of DNA-templated transcription initiation
K0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
K0000428cellular_componentDNA-directed RNA polymerase complex
K0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0005829cellular_componentcytosol
K0006351biological_processDNA-templated transcription
K0006352biological_processDNA-templated transcription initiation
K0006879biological_processintracellular iron ion homeostasis
K0009408biological_processresponse to heat
K0016740molecular_functiontransferase activity
K0016779molecular_functionnucleotidyltransferase activity
K0030880cellular_componentRNA polymerase complex
K0031564biological_processtranscription antitermination
K0032784biological_processregulation of DNA-templated transcription elongation
K0034062molecular_function5'-3' RNA polymerase activity
K0036460biological_processcellular response to cell envelope stress
K0042128biological_processnitrate assimilation
K0044780biological_processbacterial-type flagellum assembly
K0048870biological_processcell motility
K0065003biological_processprotein-containing complex assembly
K0071973biological_processbacterial-type flagellum-dependent cell motility
K0090605biological_processsubmerged biofilm formation
K2000142biological_processregulation of DNA-templated transcription initiation
Functional Information from PROSITE/UniProt
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV
ChainResidueDetails
IGLY1063-VAL1075
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues161
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_00969","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues153
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"HAMAP-Rule","id":"MF_00969","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEEH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00969","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01321","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MEY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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