Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X15

Inward-facing state of the glutamate transporter homologue GltPh in complex with L-aspartate and sodium ions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005283	molecular_function	amino acid:sodium symporter activity
A	0005886	cellular_component	plasma membrane
A	0006835	biological_process	dicarboxylic acid transport
A	0006865	biological_process	amino acid transport
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015183	molecular_function	L-aspartate transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015501	molecular_function	glutamate:sodium symporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0070207	biological_process	protein homotrimerization
A	0070778	biological_process	L-aspartate transmembrane transport
A	0140009	biological_process	L-aspartate import across plasma membrane
A	1902476	biological_process	chloride transmembrane transport
B	0005283	molecular_function	amino acid:sodium symporter activity
B	0005886	cellular_component	plasma membrane
B	0006835	biological_process	dicarboxylic acid transport
B	0006865	biological_process	amino acid transport
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015183	molecular_function	L-aspartate transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015501	molecular_function	glutamate:sodium symporter activity
B	0016020	cellular_component	membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0070207	biological_process	protein homotrimerization
B	0070778	biological_process	L-aspartate transmembrane transport
B	0140009	biological_process	L-aspartate import across plasma membrane
B	1902476	biological_process	chloride transmembrane transport
C	0005283	molecular_function	amino acid:sodium symporter activity
C	0005886	cellular_component	plasma membrane
C	0006835	biological_process	dicarboxylic acid transport
C	0006865	biological_process	amino acid transport
C	0015108	molecular_function	chloride transmembrane transporter activity
C	0015183	molecular_function	L-aspartate transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015501	molecular_function	glutamate:sodium symporter activity
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0070207	biological_process	protein homotrimerization
C	0070778	biological_process	L-aspartate transmembrane transport
C	0140009	biological_process	L-aspartate import across plasma membrane
C	1902476	biological_process	chloride transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 501

Chain	Residue
A	GLY306
A	ASN310
A	ASN401
A	ASP405
A	HOH602

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 502

Chain	Residue
A	THR352
A	THR308
A	MET311
A	SER349
A	ILE350

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 503

Chain	Residue
A	TYR89
A	THR92
A	SER93
A	ASN310
A	ASP312

site_id	AC4
Number of Residues	12
Details	binding site for residue ASP A 504

Chain	Residue
A	ARG276
A	SER277
A	SER278
A	THR314
A	GLY354
A	VAL355
A	ALA358
A	GLY359
A	ASP394
A	ARG397
A	THR398
A	ASN401

site_id	AC5
Number of Residues	4
Details	binding site for residue HG A 505

Chain	Residue
A	LEU54
A	CYS55
A	CYS364
A	TYR383

site_id	AC6
Number of Residues	8
Details	binding site for residue 6OU A 506

Chain	Residue
A	LEU3
A	TYR4
A	TYR7
A	ILE8
A	PHE46
A	LYS196
A	GLY200
B	TYR167

site_id	AC7
Number of Residues	4
Details	binding site for residue 6OU A 507

Chain	Residue
A	PRO75
A	TYR167
C	FME1
C	TYR4

site_id	AC8
Number of Residues	8
Details	binding site for residue 6OU A 508

Chain	Residue
A	ALA127
A	ILE133
A	THR334
A	VAL335
A	GLY336
A	GLN337
A	THR340
A	SER369

site_id	AC9
Number of Residues	1
Details	binding site for residue 6OU A 509

Chain	Residue
A	ILE73

site_id	AD1
Number of Residues	2
Details	binding site for residue 6OU A 511

Chain	Residue
A	PHE95
A	TYR254

site_id	AD2
Number of Residues	1
Details	binding site for residue 6OU A 512

Chain	Residue
A	TYR254

site_id	AD3
Number of Residues	2
Details	binding site for residue 6OU A 517

Chain	Residue
A	PHE46
A	PHE210

site_id	AD4
Number of Residues	2
Details	binding site for residue 6OU A 518

Chain	Residue
A	LEU134
C	PHE46

site_id	AD5
Number of Residues	2
Details	binding site for residue 6OU B 501

Chain	Residue
A	PHE46
B	LEU134

site_id	AD6
Number of Residues	5
Details	binding site for residue NA B 502

Chain	Residue
B	GLY306
B	ASN310
B	ASN401
B	ASP405
B	HOH602

site_id	AD7
Number of Residues	5
Details	binding site for residue NA B 503

Chain	Residue
B	THR308
B	MET311
B	SER349
B	ILE350
B	THR352

site_id	AD8
Number of Residues	5
Details	binding site for residue NA B 504

Chain	Residue
B	TYR89
B	THR92
B	SER93
B	ASN310
B	ASP312

site_id	AD9
Number of Residues	12
Details	binding site for residue ASP B 505

Chain	Residue
B	ARG276
B	SER277
B	SER278
B	THR314
B	GLY354
B	VAL355
B	ALA358
B	GLY359
B	ASP394
B	ARG397
B	THR398
B	ASN401

site_id	AE1
Number of Residues	4
Details	binding site for residue HG B 506

Chain	Residue
B	LEU54
B	CYS55
B	CYS364
B	TYR383

site_id	AE2
Number of Residues	8
Details	binding site for residue 6OU B 507

Chain	Residue
C	TYR167
B	LEU3
B	TYR4
B	TYR7
B	ILE8
B	PHE46
B	LYS196
B	GLY200

site_id	AE3
Number of Residues	3
Details	binding site for residue 6OU B 508

Chain	Residue
A	TYR4
B	PRO75
B	TYR167

site_id	AE4
Number of Residues	8
Details	binding site for residue 6OU B 509

Chain	Residue
B	ALA127
B	ILE133
B	THR334
B	VAL335
B	GLY336
B	GLN337
B	THR340
B	SER369

site_id	AE5
Number of Residues	1
Details	binding site for residue 6OU B 510

Chain	Residue
B	ILE73

site_id	AE6
Number of Residues	2
Details	binding site for residue 6OU B 512

Chain	Residue
B	PHE95
B	TYR254

site_id	AE7
Number of Residues	1
Details	binding site for residue 6OU B 513

Chain	Residue
B	TYR254

site_id	AE8
Number of Residues	2
Details	binding site for residue 6OU B 518

Chain	Residue
B	PHE46
B	PHE210

site_id	AE9
Number of Residues	2
Details	binding site for residue 6OU C 501

Chain	Residue
B	PHE46
C	LEU134

site_id	AF1
Number of Residues	5
Details	binding site for residue NA C 502

Chain	Residue
C	GLY306
C	ASN310
C	ASN401
C	ASP405
C	HOH602

site_id	AF2
Number of Residues	5
Details	binding site for residue NA C 503

Chain	Residue
C	THR308
C	MET311
C	SER349
C	ILE350
C	THR352

site_id	AF3
Number of Residues	5
Details	binding site for residue NA C 504

Chain	Residue
C	TYR89
C	THR92
C	SER93
C	ASN310
C	ASP312

site_id	AF4
Number of Residues	12
Details	binding site for residue ASP C 505

Chain	Residue
C	ARG276
C	SER277
C	SER278
C	THR314
C	GLY354
C	VAL355
C	ALA358
C	GLY359
C	ASP394
C	ARG397
C	THR398
C	ASN401

site_id	AF5
Number of Residues	4
Details	binding site for residue HG C 506

Chain	Residue
C	LEU54
C	CYS55
C	CYS364
C	TYR383

site_id	AF6
Number of Residues	8
Details	binding site for residue 6OU C 507

Chain	Residue
A	TYR167
C	LEU3
C	TYR4
C	TYR7
C	ILE8
C	PHE46
C	LYS196
C	GLY200

site_id	AF7
Number of Residues	3
Details	binding site for residue 6OU C 508

Chain	Residue
B	TYR4
C	PRO75
C	TYR167

site_id	AF8
Number of Residues	8
Details	binding site for residue 6OU C 509

Chain	Residue
C	ALA127
C	ILE133
C	THR334
C	VAL335
C	GLY336
C	GLN337
C	THR340
C	SER369

site_id	AF9
Number of Residues	1
Details	binding site for residue 6OU C 510

Chain	Residue
C	ILE73

site_id	AG1
Number of Residues	2
Details	binding site for residue 6OU C 512

Chain	Residue
C	PHE95
C	TYR254

site_id	AG2
Number of Residues	1
Details	binding site for residue 6OU C 513

Chain	Residue
C	TYR254

site_id	AG3
Number of Residues	2
Details	binding site for residue 6OU C 518

Chain	Residue
C	PHE46
C	PHE210

site_id	AG4
Number of Residues	4
Details	binding site for Di-peptide FME B 1 and GLY B 2

Chain	Residue
B	LEU3
B	TYR4
B	ARG5
B	LYS6

site_id	AG5
Number of Residues	5
Details	binding site for Di-peptide FME C 1 and GLY C 2

Chain	Residue
A	6OU507
C	LEU3
C	TYR4
C	ARG5
C	LYS6

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	216
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	201
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	114
Details	Transmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	186
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	66
Details	Transmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17230192","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KBC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17230192","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2NWX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17230192","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2NWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X2S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)