6X10

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with haloperidol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0008080	molecular_function	N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030649	biological_process	aminoglycoside antibiotic catabolic process
A	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
A	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0043655	cellular_component	host extracellular space
A	0044161	cellular_component	host cell cytoplasmic vesicle
A	0046677	biological_process	response to antibiotic
A	0051701	biological_process	biological process involved in interaction with host
A	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
A	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
A	0052041	biological_process	symbiont-mediated suppression of host programmed cell death
A	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
A	0061733	molecular_function	protein-lysine-acetyltransferase activity
A	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GMJ A 501

Chain	Residue
A	ALA33
A	ARG37
A	LEU63
A	SER83
A	PHE84
A	GLU401
A	PHE402
A	HOH682

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 502

Chain	Residue
A	GLN185
A	VAL394
A	HOH886
A	GLU74

---

site_id	AC3
Number of Residues	2
Details	binding site for residue NA A 503

Chain	Residue
A	GLU401
A	HOH703

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 504

Chain	Residue
A	ARG37
A	VAL40
A	PRO41
A	THR42
A	HOH601
A	HOH625
A	HOH707

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 505

Chain	Residue
A	HIS105
A	ARG106
A	ARG297
A	MET299

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CL A 506

Chain	Residue
A	THR269
A	GLN397
A	THR398
A	HOH736
A	HOH782
A	HOH811

---

site_id	AC7
Number of Residues	2
Details	binding site for residue NA A 508

Chain	Residue
A	ALA35
A	GLU199

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor; via carboxylate","evidences":[{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22547814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3RYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22547814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24106131","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27010218","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3RYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---