6X10
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with haloperidol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0033661 | biological_process | effector-mediated defense to host-produced reactive oxygen species |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043655 | cellular_component | host extracellular space |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051701 | biological_process | biological process involved in interaction with host |
| A | 0052032 | biological_process | symbiont-mediated perturbation of host inflammatory response |
| A | 0052040 | biological_process | symbiont-mediated perturbation of host programmed cell death |
| A | 0052041 | biological_process | symbiont-mediated suppression of host programmed cell death |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| A | 0097691 | cellular_component | bacterial extracellular vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GMJ A 501 |
| Chain | Residue |
| A | ALA33 |
| A | ARG37 |
| A | LEU63 |
| A | SER83 |
| A | PHE84 |
| A | GLU401 |
| A | PHE402 |
| A | HOH682 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 502 |
| Chain | Residue |
| A | GLN185 |
| A | VAL394 |
| A | HOH886 |
| A | GLU74 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 503 |
| Chain | Residue |
| A | GLU401 |
| A | HOH703 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ARG37 |
| A | VAL40 |
| A | PRO41 |
| A | THR42 |
| A | HOH601 |
| A | HOH625 |
| A | HOH707 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | HIS105 |
| A | ARG106 |
| A | ARG297 |
| A | MET299 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | THR269 |
| A | GLN397 |
| A | THR398 |
| A | HOH736 |
| A | HOH782 |
| A | HOH811 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 508 |
| Chain | Residue |
| A | ALA35 |
| A | GLU199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:21628583 |
| Chain | Residue | Details |
| A | TYR126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583 |
| Chain | Residue | Details |
| A | PHE402 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO |
| Chain | Residue | Details |
| A | VAL85 | |
| A | SER121 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO |
| Chain | Residue | Details |
| A | ARG93 |
