Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X0N

Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000786	cellular_component	nucleosome
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0030527	molecular_function	structural constituent of chromatin
a	0046982	molecular_function	protein heterodimerization activity
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005694	cellular_component	chromosome
b	0006334	biological_process	nucleosome assembly
b	0030527	molecular_function	structural constituent of chromatin
b	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
c	0000786	cellular_component	nucleosome
c	0003677	molecular_function	DNA binding
c	0005634	cellular_component	nucleus
c	0005694	cellular_component	chromosome
c	0030527	molecular_function	structural constituent of chromatin
c	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
d	0000786	cellular_component	nucleosome
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005694	cellular_component	chromosome
d	0030527	molecular_function	structural constituent of chromatin
d	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
e	0000786	cellular_component	nucleosome
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0030527	molecular_function	structural constituent of chromatin
e	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005694	cellular_component	chromosome
f	0006334	biological_process	nucleosome assembly
f	0030527	molecular_function	structural constituent of chromatin
f	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
g	0000786	cellular_component	nucleosome
g	0003677	molecular_function	DNA binding
g	0005634	cellular_component	nucleus
g	0005694	cellular_component	chromosome
g	0030527	molecular_function	structural constituent of chromatin
g	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
h	0000786	cellular_component	nucleosome
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005694	cellular_component	chromosome
h	0030527	molecular_function	structural constituent of chromatin
h	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
O	0000785	cellular_component	chromatin
O	0003682	molecular_function	chromatin binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0006281	biological_process	DNA repair
O	0006302	biological_process	double-strand break repair
O	0006974	biological_process	DNA damage response
O	0010835	biological_process	regulation of protein ADP-ribosylation
O	0042393	molecular_function	histone binding
O	0072572	molecular_function	poly-ADP-D-ribose binding
O	0090734	cellular_component	site of DNA damage
O	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
O	0140861	biological_process	DNA repair-dependent chromatin remodeling
P	0003677	molecular_function	DNA binding
P	0003682	molecular_function	chromatin binding
P	0003684	molecular_function	damaged DNA binding
P	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005730	cellular_component	nucleolus
P	0006281	biological_process	DNA repair
P	0006284	biological_process	base-excision repair
P	0006302	biological_process	double-strand break repair
P	0006974	biological_process	DNA damage response
P	0016757	molecular_function	glycosyltransferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0030592	biological_process	DNA ADP-ribosylation
P	0031491	molecular_function	nucleosome binding
P	0046697	biological_process	decidualization
P	0061051	biological_process	positive regulation of cell growth involved in cardiac muscle cell development
P	0070212	biological_process	protein poly-ADP-ribosylation
P	0070213	biological_process	protein auto-ADP-ribosylation
P	0072572	molecular_function	poly-ADP-D-ribose binding
P	0090649	biological_process	response to oxygen-glucose deprivation
P	0090734	cellular_component	site of DNA damage
P	0097191	biological_process	extrinsic apoptotic signaling pathway
P	0110088	biological_process	hippocampal neuron apoptotic process
P	0140294	molecular_function	NAD DNA ADP-ribosyltransferase activity
P	0140805	molecular_function	NAD+-protein-serine ADP-ribosyltransferase activity
P	0140806	molecular_function	NAD+- protein-aspartate ADP-ribosyltransferase activity
P	0140807	molecular_function	NAD+-protein-glutamate ADP-ribosyltransferase activity
P	0140861	biological_process	DNA repair-dependent chromatin remodeling
P	0160004	molecular_function	poly-ADP-D-ribose modification-dependent protein binding
P	1990404	molecular_function	NAD+-protein ADP-ribosyltransferase activity
R	0003677	molecular_function	DNA binding
R	0003682	molecular_function	chromatin binding
R	0003684	molecular_function	damaged DNA binding
R	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005730	cellular_component	nucleolus
R	0006281	biological_process	DNA repair
R	0006284	biological_process	base-excision repair
R	0006302	biological_process	double-strand break repair
R	0006974	biological_process	DNA damage response
R	0016757	molecular_function	glycosyltransferase activity
R	0016779	molecular_function	nucleotidyltransferase activity
R	0030592	biological_process	DNA ADP-ribosylation
R	0031491	molecular_function	nucleosome binding
R	0046697	biological_process	decidualization
R	0061051	biological_process	positive regulation of cell growth involved in cardiac muscle cell development
R	0070212	biological_process	protein poly-ADP-ribosylation
R	0070213	biological_process	protein auto-ADP-ribosylation
R	0072572	molecular_function	poly-ADP-D-ribose binding
R	0090649	biological_process	response to oxygen-glucose deprivation
R	0090734	cellular_component	site of DNA damage
R	0097191	biological_process	extrinsic apoptotic signaling pathway
R	0110088	biological_process	hippocampal neuron apoptotic process
R	0140294	molecular_function	NAD DNA ADP-ribosyltransferase activity
R	0140805	molecular_function	NAD+-protein-serine ADP-ribosyltransferase activity
R	0140806	molecular_function	NAD+- protein-aspartate ADP-ribosyltransferase activity
R	0140807	molecular_function	NAD+-protein-glutamate ADP-ribosyltransferase activity
R	0140861	biological_process	DNA repair-dependent chromatin remodeling
R	0160004	molecular_function	poly-ADP-D-ribose modification-dependent protein binding
R	1990404	molecular_function	NAD+-protein ADP-ribosyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANPKA

Chain	Residue	Details
P	LEU485-ALA492

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HgsrmSnwVgILSHG

Chain	Residue	Details
P	HIS415-GLY429

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250

Chain	Residue	Details
C	SER1
d	LYS9
d	LYS12
d	LYS17
h	LYS2
h	LYS9
h	LYS12
h	LYS17
G	SER1
c	SER1
g	SER1
H	LYS2
H	LYS9
H	LYS12
H	LYS17
d	LYS2

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250

Chain	Residue	Details
C	LYS5
G	LYS5
c	LYS5
g	LYS5
R	HIS428
R	ALA437
R	PHE444
R	GLY470

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS9
C	LYS95
G	LYS9
G	LYS95
c	LYS9
c	LYS95
g	LYS9
g	LYS95

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS36
G	LYS36
c	LYS36
g	LYS36
d	LYS117
h	LYS117

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS74
b	LYS16
b	LYS44
b	LYS79
f	LYS8
f	LYS16
f	LYS44
f	LYS79
C	LYS75
G	LYS74
G	LYS75
c	LYS74
c	LYS75
g	LYS74
g	LYS75
b	LYS8

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N5-methylglutamine => ECO:0000250

Chain	Residue	Details
C	GLN104
G	GLN104
c	GLN104
g	GLN104
b	LYS12
b	LYS20
f	LYS12
f	LYS20

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS118
G	LYS118
c	LYS118
g	LYS118
b	LYS31
b	LYS91
f	LYS31
f	LYS91

site_id	SWS_FT_FI8
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
C	LYS13
c	LYS15
c	LYS119
g	LYS13
g	LYS15
g	LYS119
F	SER47
C	LYS15
C	LYS119
G	LYS13
G	LYS15
G	LYS119
c	LYS13

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
B	TYR51
B	TYR88
F	TYR51
F	TYR88
b	TYR51
b	TYR88
f	TYR51
f	TYR88

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
B	LYS59
E	LYS64
a	LYS18
a	LYS23
a	LYS27
a	LYS36
a	LYS64
e	LYS18
e	LYS23
e	LYS27
e	LYS36
F	LYS59
e	LYS64
b	LYS59
f	LYS59
A	LYS64
E	LYS18
E	LYS23
E	LYS27
E	LYS36

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
B	LYS77
F	LYS77
b	LYS77
f	LYS77

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
B	LYS31
F	LYS31
b	LYS31
f	LYS31

site_id	SWS_FT_FI13
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
A	LYS37
B	LYS91
a	LYS37
F	LYS91
b	LYS91
f	LYS91

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	TYR41
E	TYR41
a	TYR41
e	TYR41

site_id	SWS_FT_FI15
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P84228

Chain	Residue	Details
A	LYS56
A	LYS79
E	LYS56
E	LYS79
a	LYS56
a	LYS79
e	LYS56
e	LYS79

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER57
E	SER57
a	SER57
e	SER57

site_id	SWS_FT_FI17
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR80
A	THR107
E	THR80
E	THR107
a	THR80
a	THR107
e	THR80
e	THR107

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	SER86
E	SER86
a	SER86
e	SER86

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS115
E	LYS115
a	LYS115
e	LYS115

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS122
E	LYS122
a	LYS122
e	LYS122

site_id	SWS_FT_FI21
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	CYS110
E	CYS110
a	CYS110
e	CYS110

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)