Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X0K

Structure of dithionite-reduced SidA ornithine hydroxylase with the FAD "in" and complexed with L-ornithine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005575	cellular_component	cellular_component
A	0006696	biological_process	ergosterol biosynthetic process
A	0006879	biological_process	intracellular iron ion homeostasis
A	0010106	biological_process	cellular response to iron ion starvation
A	0019290	biological_process	siderophore biosynthetic process
A	0031169	biological_process	ferrichrome biosynthetic process
A	0031172	molecular_function	ornithine N5-monooxygenase activity
A	0033214	biological_process	siderophore-dependent iron import into cell
A	0044550	biological_process	secondary metabolite biosynthetic process
A	0070401	molecular_function	NADP+ binding
B	0000166	molecular_function	nucleotide binding
B	0004497	molecular_function	monooxygenase activity
B	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005575	cellular_component	cellular_component
B	0006696	biological_process	ergosterol biosynthetic process
B	0006879	biological_process	intracellular iron ion homeostasis
B	0010106	biological_process	cellular response to iron ion starvation
B	0019290	biological_process	siderophore biosynthetic process
B	0031169	biological_process	ferrichrome biosynthetic process
B	0031172	molecular_function	ornithine N5-monooxygenase activity
B	0033214	biological_process	siderophore-dependent iron import into cell
B	0044550	biological_process	secondary metabolite biosynthetic process
B	0070401	molecular_function	NADP+ binding
C	0000166	molecular_function	nucleotide binding
C	0004497	molecular_function	monooxygenase activity
C	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005575	cellular_component	cellular_component
C	0006696	biological_process	ergosterol biosynthetic process
C	0006879	biological_process	intracellular iron ion homeostasis
C	0010106	biological_process	cellular response to iron ion starvation
C	0019290	biological_process	siderophore biosynthetic process
C	0031169	biological_process	ferrichrome biosynthetic process
C	0031172	molecular_function	ornithine N5-monooxygenase activity
C	0033214	biological_process	siderophore-dependent iron import into cell
C	0044550	biological_process	secondary metabolite biosynthetic process
C	0070401	molecular_function	NADP+ binding
D	0000166	molecular_function	nucleotide binding
D	0004497	molecular_function	monooxygenase activity
D	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005575	cellular_component	cellular_component
D	0006696	biological_process	ergosterol biosynthetic process
D	0006879	biological_process	intracellular iron ion homeostasis
D	0010106	biological_process	cellular response to iron ion starvation
D	0019290	biological_process	siderophore biosynthetic process
D	0031169	biological_process	ferrichrome biosynthetic process
D	0031172	molecular_function	ornithine N5-monooxygenase activity
D	0033214	biological_process	siderophore-dependent iron import into cell
D	0044550	biological_process	secondary metabolite biosynthetic process
D	0070401	molecular_function	NADP+ binding
E	0000166	molecular_function	nucleotide binding
E	0004497	molecular_function	monooxygenase activity
E	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005575	cellular_component	cellular_component
E	0006696	biological_process	ergosterol biosynthetic process
E	0006879	biological_process	intracellular iron ion homeostasis
E	0010106	biological_process	cellular response to iron ion starvation
E	0019290	biological_process	siderophore biosynthetic process
E	0031169	biological_process	ferrichrome biosynthetic process
E	0031172	molecular_function	ornithine N5-monooxygenase activity
E	0033214	biological_process	siderophore-dependent iron import into cell
E	0044550	biological_process	secondary metabolite biosynthetic process
E	0070401	molecular_function	NADP+ binding
F	0000166	molecular_function	nucleotide binding
F	0004497	molecular_function	monooxygenase activity
F	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005575	cellular_component	cellular_component
F	0006696	biological_process	ergosterol biosynthetic process
F	0006879	biological_process	intracellular iron ion homeostasis
F	0010106	biological_process	cellular response to iron ion starvation
F	0019290	biological_process	siderophore biosynthetic process
F	0031169	biological_process	ferrichrome biosynthetic process
F	0031172	molecular_function	ornithine N5-monooxygenase activity
F	0033214	biological_process	siderophore-dependent iron import into cell
F	0044550	biological_process	secondary metabolite biosynthetic process
F	0070401	molecular_function	NADP+ binding
G	0000166	molecular_function	nucleotide binding
G	0004497	molecular_function	monooxygenase activity
G	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005575	cellular_component	cellular_component
G	0006696	biological_process	ergosterol biosynthetic process
G	0006879	biological_process	intracellular iron ion homeostasis
G	0010106	biological_process	cellular response to iron ion starvation
G	0019290	biological_process	siderophore biosynthetic process
G	0031169	biological_process	ferrichrome biosynthetic process
G	0031172	molecular_function	ornithine N5-monooxygenase activity
G	0033214	biological_process	siderophore-dependent iron import into cell
G	0044550	biological_process	secondary metabolite biosynthetic process
G	0070401	molecular_function	NADP+ binding
H	0000166	molecular_function	nucleotide binding
H	0004497	molecular_function	monooxygenase activity
H	0004499	molecular_function	N,N-dimethylaniline monooxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005575	cellular_component	cellular_component
H	0006696	biological_process	ergosterol biosynthetic process
H	0006879	biological_process	intracellular iron ion homeostasis
H	0010106	biological_process	cellular response to iron ion starvation
H	0019290	biological_process	siderophore biosynthetic process
H	0031169	biological_process	ferrichrome biosynthetic process
H	0031172	molecular_function	ornithine N5-monooxygenase activity
H	0033214	biological_process	siderophore-dependent iron import into cell
H	0044550	biological_process	secondary metabolite biosynthetic process
H	0070401	molecular_function	NADP+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue FDA A 601

Chain	Residue
A	GLY46
A	MET94
A	GLN102
A	ILE103
A	GLU166
A	GLU167
A	VAL168
A	ALA209
A	ILE210
A	GLY211
A	TYR407
A	GLY48
A	ARG409
A	SER466
A	LEU467
A	LEU468
A	HOH704
A	HOH707
A	HOH710
A	HOH737
A	PRO49
A	ALA50
A	GLU83
A	ARG84
A	GLN85
A	TRP90
A	HIS91

site_id	AC2
Number of Residues	9
Details	binding site for residue ORN A 602

Chain	Residue
A	GLN102
A	ILE103
A	LYS107
A	ASN293
A	PHE296
A	ASN323
A	LEU467
A	SER469
A	HOH749

site_id	AC3
Number of Residues	26
Details	binding site for residue FDA B 601

Chain	Residue
B	VAL45
B	GLY46
B	GLY48
B	PRO49
B	ALA50
B	LEU82
B	GLU83
B	ARG84
B	GLN85
B	TRP90
B	HIS91
B	MET94
B	MET101
B	GLN102
B	ILE103
B	GLU166
B	VAL168
B	ALA209
B	ILE210
B	GLY211
B	TYR407
B	SER466
B	LEU467
B	LEU468
B	HOH717
B	HOH720

site_id	AC4
Number of Residues	9
Details	binding site for residue ORN B 602

Chain	Residue
B	GLN102
B	ILE103
B	LYS107
B	ASN293
B	PHE296
B	ASN323
B	SER469
B	HOH739
B	HOH756

site_id	AC5
Number of Residues	25
Details	binding site for residue FDA C 601

Chain	Residue
C	GLY46
C	GLY48
C	PRO49
C	ALA50
C	LEU82
C	GLU83
C	ARG84
C	GLN85
C	TRP90
C	HIS91
C	MET94
C	MET101
C	GLN102
C	ILE103
C	GLU166
C	VAL168
C	ALA209
C	ILE210
C	GLY211
C	TYR407
C	ARG409
C	SER466
C	LEU467
C	LEU468
C	HOH706

site_id	AC6
Number of Residues	23
Details	binding site for residue FDA D 601

Chain	Residue
D	LEU82
D	GLU83
D	ARG84
D	GLN85
D	TRP90
D	HIS91
D	MET94
D	MET101
D	GLN102
D	ILE103
D	GLU166
D	VAL168
D	ALA209
D	ILE210
D	GLY211
D	SER466
D	LEU467
D	LEU468
D	HOH719
D	HOH725
D	GLY46
D	PRO49
D	ALA50

site_id	AC7
Number of Residues	8
Details	binding site for residue ORN D 602

Chain	Residue
D	GLN102
D	ILE103
D	LYS107
D	ASN293
D	PHE296
D	ASN323
D	LEU467
D	SER469

site_id	AC8
Number of Residues	27
Details	binding site for residue FDA E 601

Chain	Residue
E	GLY46
E	GLY48
E	PRO49
E	ALA50
E	GLU83
E	ARG84
E	GLN85
E	TRP90
E	HIS91
E	MET94
E	MET101
E	GLN102
E	ILE103
E	GLU166
E	GLU167
E	VAL168
E	ILE210
E	GLY211
E	TYR407
E	ARG409
E	SER466
E	LEU467
E	LEU468
E	HOH706
E	HOH724
E	HOH725
E	HOH731

site_id	AC9
Number of Residues	8
Details	binding site for residue ORN E 602

Chain	Residue
E	GLN102
E	ILE103
E	LYS107
E	ASN293
E	PHE296
E	ASN323
E	LEU467
E	SER469

site_id	AD1
Number of Residues	21
Details	binding site for residue FDA F 601

Chain	Residue
F	GLY46
F	GLY48
F	PRO49
F	ALA50
F	GLU83
F	ARG84
F	GLN85
F	TRP90
F	HIS91
F	MET94
F	GLN102
F	ILE103
F	GLU166
F	VAL168
F	ALA209
F	ILE210
F	GLY211
F	TYR407
F	SER466
F	LEU467
F	LEU468

site_id	AD2
Number of Residues	26
Details	binding site for residue FDA G 601

Chain	Residue
G	GLY46
G	GLY48
G	PRO49
G	ALA50
G	GLU83
G	ARG84
G	GLN85
G	TRP90
G	HIS91
G	MET94
G	MET101
G	GLN102
G	ILE103
G	ARG144
G	GLU166
G	GLU167
G	VAL168
G	ILE210
G	GLY211
G	TYR407
G	ARG409
G	SER466
G	LEU467
G	LEU468
G	ORN602
G	HOH712

site_id	AD3
Number of Residues	8
Details	binding site for residue ORN G 602

Chain	Residue
G	GLN102
G	ILE103
G	LYS107
G	ASN293
G	PHE296
G	ASN323
G	SER469
G	FDA601

site_id	AD4
Number of Residues	25
Details	binding site for residue FDA H 601

Chain	Residue
H	VAL45
H	GLY46
H	PRO49
H	ALA50
H	LEU82
H	GLU83
H	ARG84
H	GLN85
H	TRP90
H	HIS91
H	MET94
H	MET101
H	GLN102
H	ILE103
H	ARG144
H	GLU166
H	VAL168
H	ALA209
H	ILE210
H	GLY211
H	TYR407
H	SER466
H	LEU467
H	LEU468
H	HOH720

site_id	AD5
Number of Residues	8
Details	binding site for residue ORN H 602

Chain	Residue
H	ILE103
H	LYS107
H	ASN293
H	PHE296
H	ASN323
H	LEU467
H	SER469
H	HOH715

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	BINDING: BINDING => ECO:0000269\|PubMed:22928747

Chain	Residue	Details
B	ASN293
B	ASN323
B	SER466
B	SER469
C	GLU83
C	GLN102
C	LYS107
C	VAL168
C	SER254
C	ARG279
C	ASN293
C	ASN323
C	SER466
C	SER469
D	GLU83
D	GLN102
D	LYS107
D	VAL168
D	SER254
D	ARG279
D	ASN293
D	ASN323
D	SER466
D	SER469
E	GLU83
E	GLN102
E	LYS107
E	VAL168
E	SER254
E	ARG279
E	ASN293
E	ASN323
E	SER466
E	SER469
F	GLU83
F	GLN102
F	LYS107
F	VAL168
F	SER254
F	ARG279
F	ASN293
F	ASN323
F	SER466
F	SER469
G	GLU83
G	GLN102
G	LYS107
G	VAL168
G	SER254
G	ARG279
G	ASN293
G	ASN323
G	SER466
G	SER469
H	GLU83
H	GLN102
H	LYS107
H	VAL168
H	SER254
H	ARG279
H	ASN293
H	ASN323
H	SER466
H	SER469
A	GLU83
A	GLN102
A	LYS107
A	VAL168
A	SER254
A	ARG279
A	ASN293
A	ASN323
A	SER466
A	SER469
B	GLU83
B	GLN102
B	LYS107
B	VAL168
B	SER254
B	ARG279

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)