6X0C
Tryptophan Synthase mutant beta-Q114A in complex with Cesium ion at the metal coordination site and aminoacrylate and benzimidazole at the enzyme beta site
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000162 | biological_process | tryptophan biosynthetic process |
A | 0003824 | molecular_function | catalytic activity |
A | 0004834 | molecular_function | tryptophan synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0006568 | biological_process | tryptophan metabolic process |
A | 0008152 | biological_process | metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0016829 | molecular_function | lyase activity |
B | 0000162 | biological_process | tryptophan biosynthetic process |
B | 0004834 | molecular_function | tryptophan synthase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006568 | biological_process | tryptophan metabolic process |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0016829 | molecular_function | lyase activity |
B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue BZI A 601 |
Chain | Residue |
A | PHE22 |
A | GLU49 |
A | ASP60 |
A | LEU100 |
A | TYR175 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue EDO A 602 |
Chain | Residue |
A | HOH782 |
A | PHE82 |
A | ASN109 |
A | PHE114 |
A | HOH712 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue PEG A 603 |
Chain | Residue |
A | PHE107 |
A | ASN108 |
A | GLY110 |
B | ARG275 |
B | VAL276 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue DMS A 604 |
Chain | Residue |
A | HOH797 |
A | HOH839 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue CL A 605 |
Chain | Residue |
A | ALA167 |
A | GLY170 |
A | HIS204 |
A | HOH744 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue CL A 606 |
Chain | Residue |
A | GLU16 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue BZI B 801 |
Chain | Residue |
B | THR3 |
B | LEU4 |
B | LEU5 |
B | ASN6 |
site_id | AC8 |
Number of Residues | 18 |
Details | binding site for residue 0JO B 802 |
Chain | Residue |
B | HIS86 |
B | LYS87 |
B | THR110 |
B | GLY111 |
B | ALA114 |
B | HIS115 |
B | THR190 |
B | GLY232 |
B | GLY233 |
B | GLY234 |
B | SER235 |
B | ASN236 |
B | GLY303 |
B | GLU350 |
B | SER377 |
B | BZI803 |
B | HOH912 |
B | HOH1024 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue BZI B 803 |
Chain | Residue |
B | LYS87 |
B | GLU109 |
B | GLY189 |
B | THR190 |
B | GLY233 |
B | 0JO802 |
site_id | AD1 |
Number of Residues | 9 |
Details | binding site for residue PEG B 804 |
Chain | Residue |
B | ASN51 |
B | TYR52 |
B | LEU59 |
B | THR60 |
B | LYS61 |
B | LEU125 |
B | LYS219 |
B | HOH901 |
B | HOH955 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue EDO B 805 |
Chain | Residue |
B | GLN36 |
B | GLU203 |
B | ARG206 |
B | DMS809 |
B | DMS810 |
B | HOH918 |
B | HOH1022 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue DMS B 806 |
Chain | Residue |
B | TYR8 |
B | GLY10 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue DMS B 807 |
Chain | Residue |
B | LYS50 |
B | GLY54 |
B | ARG55 |
B | PRO56 |
B | GLN215 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue DMS B 808 |
Chain | Residue |
B | LEU271 |
B | ASN317 |
B | ARG363 |
B | GLU364 |
B | HOH914 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue DMS B 809 |
Chain | Residue |
B | GLN42 |
B | PHE45 |
B | ALA46 |
B | EDO805 |
B | HOH943 |
site_id | AD7 |
Number of Residues | 3 |
Details | binding site for residue DMS B 810 |
Chain | Residue |
B | GLN36 |
B | GLN42 |
B | EDO805 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue CS B 811 |
Chain | Residue |
B | THR66 |
B | THR69 |
B | THR71 |
B | HOH1181 |
site_id | AD9 |
Number of Residues | 7 |
Details | binding site for residue CS B 812 |
Chain | Residue |
B | VAL231 |
B | GLY232 |
B | GLU256 |
B | GLY268 |
B | LEU304 |
B | PHE306 |
B | SER308 |
Functional Information from PROSITE/UniProt
site_id | PS00167 |
Number of Residues | 14 |
Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG |
Chain | Residue | Details |
A | LEU48-GLY61 |
site_id | PS00168 |
Number of Residues | 15 |
Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ |
Chain | Residue | Details |
B | LEU80-GLN94 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
Chain | Residue | Details |
B | LYS87 | |
A | ASP60 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 383 |
Chain | Residue | Details |
B | LYS87 | electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
B | GLU109 | |
B | SER377 | hydrogen bond donor |