6X0C
Tryptophan Synthase mutant beta-Q114A in complex with Cesium ion at the metal coordination site and aminoacrylate and benzimidazole at the enzyme beta site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue BZI A 601 |
| Chain | Residue |
| A | PHE22 |
| A | GLU49 |
| A | ASP60 |
| A | LEU100 |
| A | TYR175 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | HOH782 |
| A | PHE82 |
| A | ASN109 |
| A | PHE114 |
| A | HOH712 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 603 |
| Chain | Residue |
| A | PHE107 |
| A | ASN108 |
| A | GLY110 |
| B | ARG275 |
| B | VAL276 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 604 |
| Chain | Residue |
| A | HOH797 |
| A | HOH839 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 605 |
| Chain | Residue |
| A | ALA167 |
| A | GLY170 |
| A | HIS204 |
| A | HOH744 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 606 |
| Chain | Residue |
| A | GLU16 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue BZI B 801 |
| Chain | Residue |
| B | THR3 |
| B | LEU4 |
| B | LEU5 |
| B | ASN6 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residue 0JO B 802 |
| Chain | Residue |
| B | HIS86 |
| B | LYS87 |
| B | THR110 |
| B | GLY111 |
| B | ALA114 |
| B | HIS115 |
| B | THR190 |
| B | GLY232 |
| B | GLY233 |
| B | GLY234 |
| B | SER235 |
| B | ASN236 |
| B | GLY303 |
| B | GLU350 |
| B | SER377 |
| B | BZI803 |
| B | HOH912 |
| B | HOH1024 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue BZI B 803 |
| Chain | Residue |
| B | LYS87 |
| B | GLU109 |
| B | GLY189 |
| B | THR190 |
| B | GLY233 |
| B | 0JO802 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue PEG B 804 |
| Chain | Residue |
| B | ASN51 |
| B | TYR52 |
| B | LEU59 |
| B | THR60 |
| B | LYS61 |
| B | LEU125 |
| B | LYS219 |
| B | HOH901 |
| B | HOH955 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 805 |
| Chain | Residue |
| B | GLN36 |
| B | GLU203 |
| B | ARG206 |
| B | DMS809 |
| B | DMS810 |
| B | HOH918 |
| B | HOH1022 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 806 |
| Chain | Residue |
| B | TYR8 |
| B | GLY10 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 807 |
| Chain | Residue |
| B | LYS50 |
| B | GLY54 |
| B | ARG55 |
| B | PRO56 |
| B | GLN215 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 808 |
| Chain | Residue |
| B | LEU271 |
| B | ASN317 |
| B | ARG363 |
| B | GLU364 |
| B | HOH914 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 809 |
| Chain | Residue |
| B | GLN42 |
| B | PHE45 |
| B | ALA46 |
| B | EDO805 |
| B | HOH943 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 810 |
| Chain | Residue |
| B | GLN36 |
| B | GLN42 |
| B | EDO805 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CS B 811 |
| Chain | Residue |
| B | THR66 |
| B | THR69 |
| B | THR71 |
| B | HOH1181 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue CS B 812 |
| Chain | Residue |
| B | VAL231 |
| B | GLY232 |
| B | GLU256 |
| B | GLY268 |
| B | LEU304 |
| B | PHE306 |
| B | SER308 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG |
| Chain | Residue | Details |
| A | LEU48-GLY61 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ |
| Chain | Residue | Details |
| B | LEU80-GLN94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 383 |
| Chain | Residue | Details |
| B | LYS87 | electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLU109 | |
| B | SER377 | hydrogen bond donor |
