6WZU

The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS189
A	CYS192
A	CYS224
A	CYS226

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	SER85
A	ASN88
A	HIS89

---

site_id	AC3
Number of Residues	2
Details	binding site for residue PO4 A 503

Chain	Residue
A	HIS47
A	SER49

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site_id	AC4
Number of Residues	7
Details	binding site for residue PO4 A 504

Chain	Residue
A	HIS73
A	ASN128
A	PRO129
A	GLN174
A	HIS175
A	GLU203
A	HOH626

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 505

Chain	Residue
A	PHE127
A	HOH649

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CL A 506

Chain	Residue
A	THR10
A	VAL11
A	ASP12
A	ASN15
A	GLU67

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL A 507

Chain	Residue
A	ARG65
A	ASP164
A	TYR264
A	TYR273
A	THR301
A	HOH614

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189-CYS226

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:32726803

Chain	Residue	Details
A	CYS111

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	HIS272
A	ASP286

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189
A	CYS192
A	CYS224
A	CYS226

---