6WYJ
Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005283 | molecular_function | amino acid:sodium symporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006865 | biological_process | amino acid transport |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015501 | molecular_function | glutamate:sodium symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046942 | biological_process | carboxylic acid transport |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070778 | biological_process | L-aspartate transmembrane transport |
| A | 0140009 | biological_process | L-aspartate import across plasma membrane |
| A | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue ASP A 501 |
| Chain | Residue |
| A | SER277 |
| A | SER278 |
| A | MET311 |
| A | GLY354 |
| A | VAL355 |
| A | PRO356 |
| A | ASP394 |
| A | ARG397 |
| A | THR398 |
Functional Information from PROSITE/UniProt
| site_id | PS00713 |
| Number of Residues | 16 |
| Details | NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. PfGDlFVrLLKMLVmP |
| Chain | Residue | Details |
| A | PRO45-PRO60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 77 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | MET1-PRO11 | |
| A | PHE63-ARG80 | |
| A | LEU161-LYS196 | |
| A | LYS252-SER260 | |
| A | LYS290-GLY297 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | VAL12-LEU30 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | GLY31-THR41 | |
| A | ALA104-GLN121 | |
| A | GLU219-LYS230 | |
| A | SER321-GLN337 | |
| A | PRO373-ALA391 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | TYR42-VAL62 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | VAL81-MET103 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | TRANSMEM: Discontinuously helical; Name=4 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | PHE122-ILE160 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | ILE197-ALA218 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | VAL231-LEU251 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 62 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | PHE261-ALA289 | |
| A | GLN338-LEU372 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | TRANSMEM: Discontinuously helical; Name=7 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | ILE298-VAL320 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | ILE392-VAL412 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17230192, ECO:0007744|PDB:2NWL, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:3KBC |
| Chain | Residue | Details |
| A | ARG276 | |
| A | THR314 | |
| A | VAL355 | |
| A | ASP394 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX |
| Chain | Residue | Details |
| A | GLY306 | |
| A | THR308 | |
| A | THR352 | |
| A | ASN401 | |
| A | ASP405 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:4X2S |
| Chain | Residue | Details |
| A | ASN310 |
