6WXR
CryoEM structure of mouse DUOX1-DUOXA1 complex in the absence of NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008104 | biological_process | protein localization |
| B | 0010729 | biological_process | positive regulation of hydrogen peroxide biosynthetic process |
| B | 0015031 | biological_process | protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0042743 | biological_process | hydrogen peroxide metabolic process |
| B | 0045666 | biological_process | positive regulation of neuron differentiation |
| B | 0050727 | biological_process | regulation of inflammatory response |
| B | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
| B | 2000609 | biological_process | regulation of thyroid hormone generation |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGNGYLSfrEF |
| Chain | Residue | Details |
| A | ASP828-PHE840 | |
| A | ASP864-PHE876 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 155 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-LEU24 | |
| B | SER73-MET183 | |
| B | THR227-PRO249 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA25-ILE45 | |
| B | PHE52-PHE72 | |
| B | LEU184-VAL204 | |
| B | GLY206-MET226 | |
| B | ALA250-VAL270 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | ARG46-LEU51 | |
| B | TYR205 | |
| B | ALA271-LEU341 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN84 | |
| B | ASN109 | |
| B | ASN121 |
