6WXR
CryoEM structure of mouse DUOX1-DUOXA1 complex in the absence of NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008104 | biological_process | intracellular protein localization |
| B | 0010729 | biological_process | positive regulation of hydrogen peroxide biosynthetic process |
| B | 0015031 | biological_process | protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0031252 | cellular_component | cell leading edge |
| B | 0042743 | biological_process | hydrogen peroxide metabolic process |
| B | 0043020 | cellular_component | NADPH oxidase complex |
| B | 0045666 | biological_process | positive regulation of neuron differentiation |
| B | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
| B | 0050727 | biological_process | regulation of inflammatory response |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
| B | 2000609 | biological_process | regulation of thyroid hormone generation |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGNGYLSfrEF |
| Chain | Residue | Details |
| A | ASP828-PHE840 | |
| A | ASP864-PHE876 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 174 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 140 |
| Details | Domain: {"description":"Ferric oxidoreductase","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9NRD9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WXV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32929281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
