6WVB
Takifugu rubripes VKOR-like with warfarin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016728 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| A | 0042373 | biological_process | vitamin K metabolic process |
| A | 0047057 | molecular_function | vitamin-K-epoxide reductase (warfarin-sensitive) activity |
| A | 0048038 | molecular_function | quinone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SWF A 3001 |
| Chain | Residue |
| A | SER168 |
| A | THR283 |
| A | TYR284 |
| A | ALA171 |
| A | VAL199 |
| A | PHE200 |
| A | TRP204 |
| A | ASN225 |
| A | LEU265 |
| A | ILE279 |
| A | CYS280 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WV8, ECO:0007744|PDB:6WV9, ECO:0007744|PDB:6WVA, ECO:0007744|PDB:6WVB, ECO:0007744|PDB:6WVI |
| Chain | Residue | Details |
| A | TRP152-VAL174 | |
| A | SER226-GLY240 | |
| A | MET246-LEU273 | |
| A | CYS277-LEU298 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WV8, ECO:0007744|PDB:6WV9, ECO:0007744|PDB:6WVA, ECO:0007744|PDB:6WVB, ECO:0007744|PDB:6WVI |
| Chain | Residue | Details |
| A | GLU175-ASN225 | |
| A | LYS274-LEU276 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WV8, ECO:0007744|PDB:6WV9, ECO:0007744|PDB:6WVA, ECO:0007744|PDB:6WVB, ECO:0007744|PDB:6WVI |
| Chain | Residue | Details |
| A | MET241-ALA245 | |
| A | VAL299-ASP314 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WVB |
| Chain | Residue | Details |
| A | ASN225 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WV9, ECO:0007744|PDB:6WVA |
| Chain | Residue | Details |
| A | CYS280 | |
| A | TYR284 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | VAL68 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | CRO66 | |
| A | GLN69 |
