Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6WTN

Human JAK2 JH1 domain in complex with Ruxolitinib

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue EDO A 1201
ChainResidue
AGLU1052
ALYS1053
ASER1054
AARG1127

site_idAC2
Number of Residues3
Detailsbinding site for residue EDO A 1202
ChainResidue
AMET1130
AGLY1135
AHOH1366

site_idAC3
Number of Residues2
Detailsbinding site for residue EDO A 1203
ChainResidue
APTR1008
ALYS1009

site_idAC4
Number of Residues13
Detailsbinding site for residue RXT A 1204
ChainResidue
AGLY856
AALA880
AVAL911
AMET929
AGLU930
ALEU932
AARG980
AASN981
ALEU983
AGLY993
AASP994
AHOH1357
AHOH1367

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVEmCrydplqdntgevv.....AVKK
ChainResidueDetails
ALEU855-LYS883

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLATRNILV
ChainResidueDetails
ATYR972-VAL984

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP976

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU855
ALYS882

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120
ChainResidueDetails
ATYR868
ATYR966
ATYR972

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16174768
ChainResidueDetails
APTR1007

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:16174768
ChainResidueDetails
APTR1008

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon