6WTI
The Cryo-EM structure of the ubiquinol oxidase from Escherichia coli
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004129 | molecular_function | cytochrome-c oxidase activity |
A | 0005507 | molecular_function | copper ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0009055 | molecular_function | electron transfer activity |
A | 0009060 | biological_process | aerobic respiration |
A | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
A | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
A | 0015078 | molecular_function | proton transmembrane transporter activity |
A | 0015453 | molecular_function | oxidoreduction-driven active transmembrane transporter activity |
A | 0015990 | biological_process | electron transport coupled proton transport |
A | 0016020 | cellular_component | membrane |
A | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
A | 0019646 | biological_process | aerobic electron transport chain |
A | 0020037 | molecular_function | heme binding |
A | 0022904 | biological_process | respiratory electron transport chain |
A | 0046872 | molecular_function | metal ion binding |
A | 0048039 | molecular_function | ubiquinone binding |
A | 0070469 | cellular_component | respirasome |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0004129 | molecular_function | cytochrome-c oxidase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
B | 0016020 | cellular_component | membrane |
B | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
B | 0022900 | biological_process | electron transport chain |
C | 0004129 | molecular_function | cytochrome-c oxidase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0009055 | molecular_function | electron transfer activity |
C | 0009060 | biological_process | aerobic respiration |
C | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
C | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
C | 0015078 | molecular_function | proton transmembrane transporter activity |
C | 0015453 | molecular_function | oxidoreduction-driven active transmembrane transporter activity |
C | 0015990 | biological_process | electron transport coupled proton transport |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0019646 | biological_process | aerobic electron transport chain |
C | 0022904 | biological_process | respiratory electron transport chain |
D | 0005515 | molecular_function | protein binding |
D | 0005886 | cellular_component | plasma membrane |
D | 0009055 | molecular_function | electron transfer activity |
D | 0009060 | biological_process | aerobic respiration |
D | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
D | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
D | 0015078 | molecular_function | proton transmembrane transporter activity |
D | 0015453 | molecular_function | oxidoreduction-driven active transmembrane transporter activity |
D | 0015990 | biological_process | electron transport coupled proton transport |
D | 0016020 | cellular_component | membrane |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0019646 | biological_process | aerobic electron transport chain |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue HEM A 1001 |
Chain | Residue |
A | PHE73 |
A | HIS421 |
A | ILE424 |
A | VAL429 |
A | PHE468 |
A | ARG481 |
A | ARG482 |
A | MET79 |
A | PHE103 |
A | HIS106 |
A | GLY107 |
A | MET110 |
A | ILE111 |
A | TRP170 |
A | ILE417 |
site_id | AC2 |
Number of Residues | 26 |
Details | binding site for residue HEO A 1002 |
Chain | Residue |
A | TRP170 |
A | VAL287 |
A | TYR288 |
A | ILE291 |
A | HIS333 |
A | HIS334 |
A | ILE355 |
A | ALA356 |
A | THR359 |
A | GLY395 |
A | GLY398 |
A | VAL399 |
A | LEU401 |
A | ALA402 |
A | ASP407 |
A | HIS411 |
A | LEU416 |
A | HIS419 |
A | PHE420 |
A | VAL423 |
A | ILE424 |
A | ARG481 |
B | MET51 |
B | VAL54 |
B | VAL55 |
B | ILE100 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CU A 1003 |
Chain | Residue |
A | HIS284 |
A | HIS333 |
A | HIS334 |
site_id | AC4 |
Number of Residues | 13 |
Details | binding site for residue UQ8 A 1004 |
Chain | Residue |
A | ILE16 |
A | VAL17 |
A | THR20 |
A | LEU70 |
A | ARG71 |
A | ALA74 |
A | ASP75 |
A | MET78 |
A | HIS98 |
A | GLN101 |
A | ILE102 |
A | ASN157 |
A | LEU160 |
site_id | AC5 |
Number of Residues | 13 |
Details | binding site for residue 3PE A 1005 |
Chain | Residue |
A | PHE138 |
A | PRO139 |
A | PHE140 |
A | LEU141 |
A | GLN195 |
A | PHE602 |
A | TRP625 |
A | LYS628 |
C | LYS25 |
C | GLY28 |
C | PHE29 |
C | TYR32 |
C | 3PE401 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue 3PE A 1006 |
Chain | Residue |
A | ALA251 |
A | TRP611 |
A | 3PE1007 |
site_id | AC7 |
Number of Residues | 1 |
Details | binding site for residue 3PE A 1007 |
Chain | Residue |
A | 3PE1006 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue U9V A 1008 |
Chain | Residue |
A | TRP48 |
A | ILE62 |
A | ILE63 |
A | VAL150 |
A | TRP439 |
A | TRP440 |
A | PHE444 |
A | ARG523 |
A | 3PE1009 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue 3PE A 1009 |
Chain | Residue |
A | TYR517 |
A | ARG521 |
A | ARG523 |
A | U9V1008 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue 3PE B 401 |
Chain | Residue |
A | ILE350 |
A | ILE354 |
B | ILE101 |
B | TRP108 |
site_id | AD2 |
Number of Residues | 11 |
Details | binding site for residue 3PE C 401 |
Chain | Residue |
C | SER152 |
C | TRP156 |
C | ARG176 |
A | VAL248 |
A | ALA251 |
A | PHE618 |
A | TRP625 |
A | 3PE1005 |
C | LYS25 |
C | TYR32 |
C | HIS149 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue 3PE C 402 |
Chain | Residue |
C | PHE120 |
C | HIS121 |
C | ILE124 |
C | ALA141 |
C | GLY144 |
C | THR145 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue 3PE D 201 |
Chain | Residue |
C | PHE44 |
C | ALA48 |
C | MET201 |
D | VAL85 |
D | ILE88 |
D | VAL93 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue 3PE D 202 |
Chain | Residue |
A | MET222 |
A | TRP230 |
A | ILE240 |
D | PHE83 |
Functional Information from PROSITE/UniProt
site_id | PS00077 |
Number of Residues | 55 |
Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WAWGHPeVyililpvfgvfseiaatfsrkrlfgytslvwatvcitvlsfivwl..HH |
Chain | Residue | Details |
A | TRP280-HIS334 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 31 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
D | MET1-THR17 | |
D | PHE65-ALA80 | |
C | VAL162-TRP184 | |
A | THR261-GLY270 | |
A | SER327-ALA340 | |
A | LEU410-ASN412 | |
A | GLY478-PRO489 | |
A | ILE607-LEU613 |
site_id | SWS_FT_FI2 |
Number of Residues | 54 |
Details | TRANSMEM: Helical => ECO:0000305 |
Chain | Residue | Details |
D | TYR18-VAL36 | |
D | ILE46-CYS64 | |
D | PHE81-MET99 | |
C | VAL143-MET161 | |
C | HIS185-ALA203 |
site_id | SWS_FT_FI3 |
Number of Residues | 17 |
Details | TOPO_DOM: Periplasmic => ECO:0000305 |
Chain | Residue | Details |
D | MET37-VAL45 | |
D | TRP100-HIS109 | |
C | MET204 | |
A | LYS308-PHE311 | |
A | MET370-PHE377 | |
A | PHE446-LEU448 | |
A | ASP522-LYS587 | |
A | ASP633-ASN663 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | LIPID: S-diacylglycerol cysteine => ECO:0000255|PROSITE-ProRule:PRU00303 |
Chain | Residue | Details |
B | CYS25 |
site_id | SWS_FT_FI5 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=III |
Chain | Residue | Details |
A | PRO96-GLY132 |
site_id | SWS_FT_FI6 |
Number of Residues | 23 |
Details | TRANSMEM: Helical; Name=IV |
Chain | Residue | Details |
A | PHE138-GLY161 |
site_id | SWS_FT_FI7 |
Number of Residues | 30 |
Details | TRANSMEM: Helical; Name=V |
Chain | Residue | Details |
A | VAL185-MET215 |
site_id | SWS_FT_FI8 |
Number of Residues | 35 |
Details | TRANSMEM: Helical; Name=VI |
Chain | Residue | Details |
A | MET225-GLY260 |
site_id | SWS_FT_FI9 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=VII |
Chain | Residue | Details |
A | ASN271-ARG307 |
site_id | SWS_FT_FI10 |
Number of Residues | 14 |
Details | TRANSMEM: Helical; Name=VIII |
Chain | Residue | Details |
A | GLY312-LEU326 |
site_id | SWS_FT_FI11 |
Number of Residues | 28 |
Details | TRANSMEM: Helical; Name=IX |
Chain | Residue | Details |
A | GLY341-THR369 |
site_id | SWS_FT_FI12 |
Number of Residues | 31 |
Details | TRANSMEM: Helical; Name=X |
Chain | Residue | Details |
A | HIS378-VAL409 |
site_id | SWS_FT_FI13 |
Number of Residues | 32 |
Details | TRANSMEM: Helical; Name=XI |
Chain | Residue | Details |
A | SER413-GLY445 |
site_id | SWS_FT_FI14 |
Number of Residues | 28 |
Details | TRANSMEM: Helical; Name=XII |
Chain | Residue | Details |
A | ASN449-MET477 |
site_id | SWS_FT_FI15 |
Number of Residues | 31 |
Details | TRANSMEM: Helical; Name=XIII |
Chain | Residue | Details |
A | GLN490-ARG521 |
site_id | SWS_FT_FI16 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=XIV |
Chain | Residue | Details |
A | ASN588-MET606 |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=XV |
Chain | Residue | Details |
A | ALA614-GLU632 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33408407, ECO:0000269|PubMed:34417297, ECO:0007744|PDB:6WTI, ECO:0007744|PDB:7CUB, ECO:0007744|PDB:7CUW, ECO:0007744|PDB:7N9Z |
Chain | Residue | Details |
A | ARG71 |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34417297, ECO:0007744|PDB:7CUW |
Chain | Residue | Details |
A | ASP75 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34417297, ECO:0007744|PDB:7CUB, ECO:0007744|PDB:7CUW, ECO:0007744|PDB:7N9Z |
Chain | Residue | Details |
A | HIS98 |
site_id | SWS_FT_FI21 |
Number of Residues | 3 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:11017202, ECO:0000269|PubMed:33408407, ECO:0007744|PDB:1FFT, ECO:0007744|PDB:6WTI |
Chain | Residue | Details |
A | HIS106 | |
A | HIS419 | |
A | HIS421 |
site_id | SWS_FT_FI22 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11017202, ECO:0007744|PDB:1FFT |
Chain | Residue | Details |
A | TRP170 |
site_id | SWS_FT_FI23 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11017202, ECO:0000269|PubMed:33408407, ECO:0007744|PDB:1FFT, ECO:0007744|PDB:6WTI |
Chain | Residue | Details |
A | HIS284 | |
A | HIS333 | |
A | HIS334 | |
A | HIS411 | |
A | ARG482 |
site_id | SWS_FT_FI24 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33408407, ECO:0007744|PDB:6WTI |
Chain | Residue | Details |
A | TYR288 | |
A | ARG481 |
site_id | SWS_FT_FI25 |
Number of Residues | 2 |
Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:34417297 |
Chain | Residue | Details |
A | HIS284 | |
A | TYR288 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 23 |
Details | M-CSA 714 |
Chain | Residue | Details |
A | TYR61 | proton shuttle (general acid/base) |
A | THR149 | proton shuttle (general acid/base) |
A | THR201 | proton shuttle (general acid/base) |
A | THR204 | proton shuttle (general acid/base) |
A | THR211 | proton shuttle (general acid/base) |
A | HIS284 | metal ligand, modifies pKa |
A | GLU286 | proton shuttle (general acid/base) |
A | TYR288 | electron shuttle, proton shuttle (general acid/base) |
A | SER299 | proton shuttle (general acid/base) |
A | SER315 | proton shuttle (general acid/base) |
A | THR359 | proton shuttle (general acid/base) |
A | ARG71 | electrostatic stabiliser |
A | LYS362 | proton shuttle (general acid/base) |
A | HIS419 | electron shuttle |
A | PHE420 | electron shuttle |
A | HIS421 | electron shuttle |
A | ASP75 | electrostatic stabiliser |
A | MET79 | electron shuttle |
A | PHE103 | electron shuttle |
A | ASN124 | proton shuttle (general acid/base) |
A | ASP135 | proton shuttle (general acid/base) |
A | ASN142 | proton shuttle (general acid/base) |
A | SER145 | proton shuttle (general acid/base) |