Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WTD

Monomer yeast ATP synthase Fo reconstituted in nanodisc with inhibitor of Bedaquiline bound

Functional Information from GO Data

Chain	GOid	namespace	contents
7	0005739	cellular_component	mitochondrion
7	0005743	cellular_component	mitochondrial inner membrane
7	0006754	biological_process	ATP biosynthetic process
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
7	0045265	cellular_component	proton-transporting ATP synthase, stator stalk
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	1902600	biological_process	proton transmembrane transport
8	0005739	cellular_component	mitochondrion
8	0005743	cellular_component	mitochondrial inner membrane
8	0006754	biological_process	ATP biosynthetic process
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0016020	cellular_component	membrane
8	0031966	cellular_component	mitochondrial membrane
8	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	1902600	biological_process	proton transmembrane transport
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005829	cellular_component	cytosol
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0031966	cellular_component	mitochondrial membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0042802	molecular_function	identical protein binding
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0031966	cellular_component	mitochondrial membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0042802	molecular_function	identical protein binding
L	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005829	cellular_component	cytosol
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0031966	cellular_component	mitochondrial membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042802	molecular_function	identical protein binding
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005829	cellular_component	cytosol
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0016887	molecular_function	ATP hydrolysis activity
N	0031966	cellular_component	mitochondrial membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042802	molecular_function	identical protein binding
N	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005829	cellular_component	cytosol
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0016887	molecular_function	ATP hydrolysis activity
O	0031966	cellular_component	mitochondrial membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042802	molecular_function	identical protein binding
O	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016020	cellular_component	membrane
P	0016887	molecular_function	ATP hydrolysis activity
P	0031966	cellular_component	mitochondrial membrane
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0042802	molecular_function	identical protein binding
P	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0005829	cellular_component	cytosol
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016020	cellular_component	membrane
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0031966	cellular_component	mitochondrial membrane
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0042802	molecular_function	identical protein binding
Q	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005758	cellular_component	mitochondrial intermembrane space
R	0005829	cellular_component	cytosol
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0016020	cellular_component	membrane
R	0016887	molecular_function	ATP hydrolysis activity
R	0031966	cellular_component	mitochondrial membrane
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0042802	molecular_function	identical protein binding
R	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005758	cellular_component	mitochondrial intermembrane space
S	0005829	cellular_component	cytosol
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016020	cellular_component	membrane
S	0016887	molecular_function	ATP hydrolysis activity
S	0031966	cellular_component	mitochondrial membrane
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0042802	molecular_function	identical protein binding
S	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005758	cellular_component	mitochondrial intermembrane space
T	0005829	cellular_component	cytosol
T	0008289	molecular_function	lipid binding
T	0015078	molecular_function	proton transmembrane transporter activity
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0016020	cellular_component	membrane
T	0016887	molecular_function	ATP hydrolysis activity
T	0031966	cellular_component	mitochondrial membrane
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0042802	molecular_function	identical protein binding
T	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
T	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
T	1902600	biological_process	proton transmembrane transport
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006754	biological_process	ATP biosynthetic process
U	0015986	biological_process	proton motive force-driven ATP synthesis
U	0016887	molecular_function	ATP hydrolysis activity
U	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
U	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
U	1902600	biological_process	proton transmembrane transport
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0006754	biological_process	ATP biosynthetic process
X	0015078	molecular_function	proton transmembrane transporter activity
X	0015986	biological_process	proton motive force-driven ATP synthesis
X	0045259	cellular_component	proton-transporting ATP synthase complex
X	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
X	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
X	1902600	biological_process	proton transmembrane transport
Z	0015078	molecular_function	proton transmembrane transporter activity
Z	0015986	biological_process	proton motive force-driven ATP synthesis

Functional Information from PROSITE/UniProt

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLGSNI

Chain	Residue	Details
X	SER172-ILE181

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPsikdtVfPmaILgfaLsE

Chain	Residue	Details
K	SER38-GLU59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
J	ILE9-TYR25
O	ILE52-LEU72
P	ILE14-ILE34
P	ILE52-LEU72
Q	ILE14-ILE34
Q	ILE52-LEU72
R	ILE14-ILE34
R	ILE52-LEU72
S	ILE14-ILE34
S	ILE52-LEU72
T	ILE14-ILE34
X	TRP82-ILE102
T	ILE52-LEU72
X	LEU115-TYR135
X	VAL140-ILE160
X	ILE181-ILE201
X	LEU206-ILE226
N	ILE14-ILE34
N	ILE52-LEU72
O	ILE14-ILE34

site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Reversibly protonated during proton transport => ECO:0000250

Chain	Residue	Details
K	GLU59
T	GLU59
L	GLU59
M	GLU59
N	GLU59
O	GLU59
P	GLU59
Q	GLU59
R	GLU59
S	GLU59

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:2894987

Chain	Residue	Details
K	FME1
T	FME1
L	FME1
M	FME1
N	FME1
O	FME1
P	FME1
Q	FME1
R	FME1
S	FME1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)