Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WSL

Cryo-EM structure of VASH1-SVBP bound to microtubules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0000793	cellular_component	condensed chromosome
A	0001764	biological_process	neuron migration
A	0001964	biological_process	startle response
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0006886	biological_process	intracellular protein transport
A	0007017	biological_process	microtubule-based process
A	0007098	biological_process	centrosome cycle
A	0007224	biological_process	smoothened signaling pathway
A	0007613	biological_process	memory
A	0007626	biological_process	locomotory behavior
A	0008344	biological_process	adult locomotory behavior
A	0008542	biological_process	visual learning
A	0009612	biological_process	response to mechanical stimulus
A	0010001	biological_process	glial cell differentiation
A	0010467	biological_process	gene expression
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0021542	biological_process	dentate gyrus development
A	0021696	biological_process	cerebellar cortex morphogenesis
A	0021766	biological_process	hippocampus development
A	0021859	biological_process	pyramidal neuron differentiation
A	0021987	biological_process	cerebral cortex development
A	0022008	biological_process	neurogenesis
A	0030182	biological_process	neuron differentiation
A	0030317	biological_process	flagellated sperm motility
A	0030534	biological_process	adult behavior
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031514	cellular_component	motile cilium
A	0031594	cellular_component	neuromuscular junction
A	0034612	biological_process	response to tumor necrosis factor
A	0035641	biological_process	locomotory exploration behavior
A	0036126	cellular_component	sperm flagellum
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0046785	biological_process	microtubule polymerization
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0048853	biological_process	forebrain morphogenesis
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0051301	biological_process	cell division
A	0051402	biological_process	neuron apoptotic process
A	0055037	cellular_component	recycling endosome
A	0061744	biological_process	motor behavior
A	0070062	cellular_component	extracellular exosome
A	0071277	biological_process	cellular response to calcium ion
A	0072384	biological_process	organelle transport along microtubule
A	0140058	biological_process	neuron projection arborization
A	1902065	biological_process	response to L-glutamate
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0007411	biological_process	axon guidance
B	0015630	cellular_component	microtubule cytoskeleton
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030182	biological_process	neuron differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0038007	biological_process	netrin-activated signaling pathway
B	0042277	molecular_function	peptide binding
B	0042995	cellular_component	cell projection
B	0043025	cellular_component	neuronal cell body
B	0045171	cellular_component	intercellular bridge
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0072686	cellular_component	mitotic spindle
B	1990791	biological_process	dorsal root ganglion development
B	1990890	molecular_function	netrin receptor binding
C	0005737	cellular_component	cytoplasm
C	0045765	biological_process	regulation of angiogenesis
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0006508	biological_process	proteolysis
D	0008017	molecular_function	microtubule binding
D	0009306	biological_process	protein secretion
D	0010596	biological_process	negative regulation of endothelial cell migration
D	0016504	molecular_function	peptidase activator activity
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0045177	cellular_component	apical part of cell
D	0061564	biological_process	axon development
D	1905048	biological_process	regulation of metallopeptidase activity
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0000793	cellular_component	condensed chromosome
E	0001764	biological_process	neuron migration
E	0001964	biological_process	startle response
E	0005198	molecular_function	structural molecule activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005879	cellular_component	axonemal microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005886	cellular_component	plasma membrane
E	0006886	biological_process	intracellular protein transport
E	0007017	biological_process	microtubule-based process
E	0007098	biological_process	centrosome cycle
E	0007224	biological_process	smoothened signaling pathway
E	0007613	biological_process	memory
E	0007626	biological_process	locomotory behavior
E	0008344	biological_process	adult locomotory behavior
E	0008542	biological_process	visual learning
E	0009612	biological_process	response to mechanical stimulus
E	0010001	biological_process	glial cell differentiation
E	0010467	biological_process	gene expression
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0021542	biological_process	dentate gyrus development
E	0021696	biological_process	cerebellar cortex morphogenesis
E	0021766	biological_process	hippocampus development
E	0021859	biological_process	pyramidal neuron differentiation
E	0021987	biological_process	cerebral cortex development
E	0022008	biological_process	neurogenesis
E	0030182	biological_process	neuron differentiation
E	0030317	biological_process	flagellated sperm motility
E	0030534	biological_process	adult behavior
E	0030705	biological_process	cytoskeleton-dependent intracellular transport
E	0031514	cellular_component	motile cilium
E	0031594	cellular_component	neuromuscular junction
E	0034612	biological_process	response to tumor necrosis factor
E	0035641	biological_process	locomotory exploration behavior
E	0036126	cellular_component	sperm flagellum
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042802	molecular_function	identical protein binding
E	0044877	molecular_function	protein-containing complex binding
E	0045202	cellular_component	synapse
E	0046785	biological_process	microtubule polymerization
E	0046872	molecular_function	metal ion binding
E	0046982	molecular_function	protein heterodimerization activity
E	0048853	biological_process	forebrain morphogenesis
E	0048873	biological_process	homeostasis of number of cells within a tissue
E	0050807	biological_process	regulation of synapse organization
E	0050808	biological_process	synapse organization
E	0051301	biological_process	cell division
E	0051402	biological_process	neuron apoptotic process
E	0055037	cellular_component	recycling endosome
E	0061744	biological_process	motor behavior
E	0070062	cellular_component	extracellular exosome
E	0071277	biological_process	cellular response to calcium ion
E	0072384	biological_process	organelle transport along microtubule
E	0140058	biological_process	neuron projection arborization
E	1902065	biological_process	response to L-glutamate
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0007411	biological_process	axon guidance
F	0015630	cellular_component	microtubule cytoskeleton
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030182	biological_process	neuron differentiation
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0038007	biological_process	netrin-activated signaling pathway
F	0042277	molecular_function	peptide binding
F	0042995	cellular_component	cell projection
F	0043025	cellular_component	neuronal cell body
F	0045171	cellular_component	intercellular bridge
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071944	cellular_component	cell periphery
F	0072686	cellular_component	mitotic spindle
F	1990791	biological_process	dorsal root ganglion development
F	1990890	molecular_function	netrin receptor binding
G	0005737	cellular_component	cytoplasm
G	0045765	biological_process	regulation of angiogenesis
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0006508	biological_process	proteolysis
H	0008017	molecular_function	microtubule binding
H	0009306	biological_process	protein secretion
H	0010596	biological_process	negative regulation of endothelial cell migration
H	0016504	molecular_function	peptidase activator activity
H	0031397	biological_process	negative regulation of protein ubiquitination
H	0045177	cellular_component	apical part of cell
H	0061564	biological_process	axon development
H	1905048	biological_process	regulation of metallopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:29146869, ECO:0000305\|PubMed:26794318

Chain	Residue	Details
C	CYS169
F	GLY144
F	ASN204
F	ASN226
G	CYS169
B	THR143
B	GLY144
B	ASN204
B	ASN226
F	GLN11
F	GLY142
F	THR143

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:26794318

Chain	Residue	Details
C	HIS204
E	GLU71
E	SER140
E	GLY144
E	THR145
E	THR179
E	ASN206
E	ASN228
C	SER221
G	HIS204
G	SER221
A	THR145
A	THR179
A	ASN206
A	ASN228
E	GLN11

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage => ECO:0000305\|PubMed:16488400

Chain	Residue	Details
C	ARG76
G	ARG76

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269\|PubMed:16371510

Chain	Residue	Details
B	SER172
F	SER172

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
B	GLU438
F	GLU438

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
B	SER444
F	SER444

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:32747782

Chain	Residue	Details
A	GLU443
E	GLU443

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:P68369

Chain	Residue	Details
A	GLU445
E	GLU445

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000269\|PubMed:10339593

Chain	Residue	Details
A	TYR451
E	TYR451

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)