6WS5

Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
CCC	0000122	biological_process	negative regulation of transcription by RNA polymerase II
CCC	0000785	cellular_component	chromatin
CCC	0001558	biological_process	regulation of cell growth
CCC	0002208	biological_process	somatic diversification of immunoglobulins involved in immune response
CCC	0003714	molecular_function	transcription corepressor activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005680	cellular_component	anaphase-promoting complex
CCC	0005694	cellular_component	chromosome
CCC	0005737	cellular_component	cytoplasm
CCC	0005819	cellular_component	spindle
CCC	0006281	biological_process	DNA repair
CCC	0006302	biological_process	double-strand break repair
CCC	0007015	biological_process	actin filament organization
CCC	0007094	biological_process	mitotic spindle assembly checkpoint signaling
CCC	0008432	molecular_function	JUN kinase binding
CCC	0010717	biological_process	regulation of epithelial to mesenchymal transition
CCC	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
CCC	0016035	cellular_component	zeta DNA polymerase complex
CCC	0019985	biological_process	translesion synthesis
CCC	0030674	molecular_function	protein-macromolecule adaptor activity
CCC	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
CCC	0035861	cellular_component	site of double-strand break
CCC	0042177	biological_process	negative regulation of protein catabolic process
CCC	0042276	biological_process	error-prone translesion synthesis
CCC	0042772	biological_process	DNA damage response, signal transduction resulting in transcription
CCC	0043247	biological_process	telomere maintenance in response to DNA damage
CCC	0045830	biological_process	positive regulation of isotype switching
CCC	0045893	biological_process	positive regulation of DNA-templated transcription
CCC	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
CCC	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
CCC	0090734	cellular_component	site of DNA damage
CCC	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
CCC	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
CCC	2000048	biological_process	negative regulation of cell-cell adhesion mediated by cadherin
CCC	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	93
Details	Region: {"description":"C-terminal domain involved in interaction with the translesion synthesis (TLS) polymerase POLH, POLK, POLD3 and MAD2L2","evidences":[{"source":"PubMed","id":"22691049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23143872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26982350","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2LSK","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2LSY","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2N1G","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4GK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4GK5","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---